L-arginine and heart disease

  1. L-arginine and heart disease

    Found this while surfing around, thought it was cool.

    L-arginine and heart disease

    STANFORD, CALIFORNIA. The inside of blood vessels is lined with a layer of single cells called the endothelium. Among other functions, the endothelium produces nitric oxide that serves to relax (vasodilate) the blood vessels so as to facilitate the flow of blood. It is now generally accepted that many heart problems involve a dysfunction of the endothelial vasodilator mechanism. Antioxidants, estrogen, exercise, folic acid, and fish oils can in a number of cases, reverse this dysfunction. Now researchers at the Stanford University School of Medicine report that supplementation with the amino acid L-arginine is highly effective in reversing endothelial dysfunction. It has been established that L-arginine is the precursor for endothelium-derived nitric oxide (EDNO). EDNO, in turn, is a potent vasodilator and inhibits platelet aggregation and the adherence of circulating blood cells to blood vessel walls. L-arginine administration, either orally or intravenously, has been found useful in preventing and reversing atherosclerosis, in increasing coronary blood flow in heart disease patients, in alleviating intermittent claudication, and in improving functional status of heart failure patients. L-arginine infusions have been found to lower blood pressure and to inhibit restenosis (reclosing of arteries) after balloon angioplasty. The most common used dosage of L-arginine is between six and thirty grams per day (113 references).
    Maxwell, Andrew J. and Cooke, John P. Cardiovascular effects of L-arginine. Current Opinion in Nephrology & Hypertension, Vol. 7, January 1998, pp. 63-70


  2. Good stuff.

    One can likely keep their dose of the newer forms of arginine lower since they tend to absorb much better..around 5-7 grams of Diarginine malate or AAKG tends to work fine for vasodialation. AEE..not sure yet.

    One should also supplement with antioxidants when taking any arg as an excess of NO can lead to an increase in oxidation, particularly of LDL cholesterol.

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