doea anyone know of safty issues with cissus?, a member of the Vitidaceae family and regarded as a medicinal plant in African countries is suspected of causing significant loss of livestock in the Sudan. Twelve Nubian goats 3 to 6 months old were given by stomach tube dried stems of C. quadrangularis finely ground in a water suspension at 0, 0.25, 0.5, 1, 5 or 10 g/kg body weight daily until death or slaughter. Nine Desert sheep 6 to 9 months old were given that suspension at 0, 1, 5 or 10 g/kg daily. Signs of poisoning included decreased appetite, staggering, dyspnoea, diarrhoea and loss of condition. Pathological changes included haemorrhaging in kidney, lung, heart and intestine, focal catarrhal enteritis and atrophy of cardiac fat, hydroperitoneum and hydropericardium.