we understand how it works pretty well, actually the mechanism of action is pretty simple- i understand the concept of the "cascade effect" and that the vector of inflammation and anabolism tend to be joined, and there are inflammation processes in which the complement proteins must be activated during each step, BUT in relation to affecting anabolism, this is not always set in stone.Originally Posted by Grunt76
different compounds can have different effects on different tissues, and substances that reduce inflammation do not always stop anabolism. that being said, stopping mast cells, histamines, and prostaglandins aren't necessarily a bad thing- and the tetracyclic triterpenoids in cissus do exactly this- mostly d-amyrin and d-amyrone, but also 7-ene-3a,21 Beta-diol, a potent inhibitor of myeloperoxidase. myeloperoxidase is an inflammatory enzyme released by the body in response to tissue damage and it results in the subsequent release of complement proteins in the cascade process. cissus reduces myeloperoxidase, therefore causing less tissue reaction around the injury site, as well as increasing calcium uptake through damaged tissue. it also causes a rapid mobilization of of fibroblasts, chondroblasts, and osteoblasts to the injury site, competes w/ cortisol at receptor level, and increases the retention of calcium, phosphorous, collagen, and mucopolysaccharides, resulting in earlier calcification and earlier callus formation- this occurs mainly due to the carbon tetrachloride content in the herb- which also increases alkaline phosphate levels. would you like to know more?