[r0dree]

Hi all, i was wondering if l-arginine, when administered in large doses, like any NO supplement can stimulate the pituitary release of prolactin to a level of nipple discharge.
I'm asking because the only two opportunities i have tried NO supplements, i would press my nipples after feeling some kind of discomfort, and tiny drops would come up.
Both times this symptom went away after a few weeks of dropping the supplement

[cretinx]

wtf

[yeahright]

Anyone else have an update on this?

[anabolicrhino]

That is unusual...but I could venture a guess that it may be negative reaction to all the ammonia that gets dumped into your blood stream through the metabolism of the arginine. I would see a MD if it continues or simply stop the Arginine input at such dramatic levels. Even at optimal ranges the positive nitrogen retention that you get from NO products comes with a slight toxic side effect in the form of ammonia, which needs to be cleansed from the blood. The liver does a good job with normal amounts but, mega dosing may be taxing yours. good luck!

[diesel22]

I had the same exact thing happen to me last nite and it scared the crap out of me. Im only taking cytogainer and cellmass right now thought so im confused as all hell. my nipples have been more sensitive lately though

[Apowerz6]

Cellmass has no L-argine in it
What's In It?
Supplement Facts:

Serving Size: 1 Scoop (16g)
Servings Per Container: 40

Amount Per Serving:

Calories 38
Sodium 70mg
Potassium 140mg
Carbs 9.5g
Calcium 80mg
Phosphorous 150mg

CEM3 3000mg
(Creatine Ethyl Ester Malate)

Glutamine AKG 2000mg

Muscle Cell Uptake Proprietary Matrix: 950mg
- Cinnulin-PF
- Calcium Phosphate
- Di-Potassium Phosphate
- Di-Sodium Phosphate

Other Ingredients:
Modified glucose polymer (maltodextrin), natural and artificial flavors, potassium citrate, sucralose, fd&c red, fd&c blue 1.

SO I have no clue why your nips are extra sensitive, and watching OH and Lifetime by your own Freewill...

[shct]

you a female? hah

The effects of L-arginine on the release of prolactin from decidual explants in vitro.

Kumari M, Heffner LJ.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

OBJECTIVE: Our aim was to elucidate a role for the L -arginine-nitric oxide-cyclic guanosine monophosphate pathway in the control of decidual prolactin release in vitro. STUDY DESIGN: In decidua obtained from normal vaginal deliveries, we examined the effects of L -arginine; a stable analog of cyclic guanosine monophosphate, 8-bromo-cyclic guanosine monophosphate; and two nitric oxide synthase inhibitors, L -nitro arginine methyl ester (L -NAME) and L -nitro monomethyl arginine (L -NMMA) on the release of prolactin from decidual tissue in vitro. RESULTS: L -arginine, at 100 micromol/L, produced an increase in medium prolactin concentration after a 2-hour exposure; however, its inactive isomer, D -arginine, at the same concentration, did not. The increase in prolactin release initiated by L -arginine was sustained after a 24-hour incubation. In addition, 8-bromo-cyclic guanosine monophosphate (10 micromol/L) stimulated prolactin release. At 2 hours, the effects of L -arginine were reversed by L -NAME (100 micromol/L), which by itself was without effect. Incubation of tissue with L -NAME for 24 hours inhibited prolactin secretion (24 hours; P <.05, vs control); however, L -NMMA was without effect. CONCLUSIONS: These results suggest that the L -arginine-nitric oxide-cyclic guanosine monophosphate pathway is involved in the regulation of prolactin secretion by decidual tissue.

PMID: 10739497 [PubMed - indexed for MEDLINE]

shct

[shct]

From PDR Health:

all other parts of article omitted from this as not relevant

L-arginine, when administered in high doses, stimulates pituitary release of growth hormone and prolactin and pancreatic release of glucagon and insulin. Intravenous L-arginine may be used as an aid in the evaluation of problems with growth and stature that may be due to growth hormone deficiency. Intravenous arginine hydrochloride may be used as a fourth-line agent in the treatment of severe metabolic alkalosis. L-arginine is also used as an immunonutrient in enteral and parenteral nutrition to help improve the immune status in those suffering from sepsis, burns and trauma.

shct

[shct]

Arginine increases Prolactin levels.

Arginine is the main constituent of any Nitric Oxide boosting program.However it also increases Prolactin levels which are negatively corelated with hair loss

Supplemental, L-arginine has also been shown to induce the release of growth hormone and prolactin.*
* Physicians Desk Reference for Nutritional Supplements, pp 248-53.


Well this isnt what I was expecting when i searched this subject via google....wheres my dostinex for plain-jane supplements??

Chaste Berry
CHASTE BERRY (Vitex), Vitex agnus-castus, 12:1, 5% flavonoids, acts on the pituitary to stimulate and normalize hormonal function. Traditional use includes help for vision problems. It is anticatabolic because it reduces the hormone prolactin. May reduce FSH and increase LH. Helpful in PMS, menopause, and may reduce estrogen in men.


shct

[shct]

Glutamine and prolactin

Acta Eur Fertil. 1983 Sep-Oct;14(5):341-4. Related Articles, Links


Effect of glutamine and nucleosides on prolactin secretion in the rat.

Bernardini R, De Luca G, Marino D.

The effect of glutamine and some nucleosides (cytidine and uridine) on basal and stimulated prolactin release was investigated in vivo and in vitro. Acute injection of glutamine did not modify serum prolactin concentration, both in basal and stimulated conditions; conversely repeated administrations of the aminoacid significantly reduced (p less than 0.05) the prolactin surge which occurs at 04:00 p.m. in male rats as well as that induced by the injection of the dopamine antagonist sulpiride. The hypoprolactinemic effect of glutamine was significantly potentiated by uridine and cytidine, which per se were not effective. No significant change in prolactin release was observed when anterior pituitary glands were incubated in presence of the above mentioned drugs. However, repeated in vivo injections of glutamine, uridine and cytidine were able to potentiate the inhibitory effect of dopamine on prolactin release in vitro. These results suggest that both glutamine and the nucleosides cytidine and uridine may influence the activity of the hypothalamic-hypophyseal-prolactin axis, probably via an interference with endogenous neurotransmitters.

PMID: 6673453 [PubMed - indexed for MEDLINE]

shct

[jmh80]

I take arginine nightly for growth hormone release.

I've not had any issues with lactation.

I'm puzzled by this.

[yeahright]

Originally Posted by jmh80

I take arginine nightly for growth hormone release.

I've not had any issues with lactation.

I'm puzzled by this.

Does this mean that you're lactating normally?

[jmh80]

Yeah.

Of course it does. Don't you see the C cups I have from my picture in my avatar????

[CHAPS]

Great info SHCT +1 for you!

[shct]

Originally Posted by yeahright

Does this mean that you're lactating normally?

hah

sorry..

shct

[Ubiquitous]

that's interesting, as NO products are used as the OTC boner inducers for people who can't get Cialis or Viagra.

Prolactin is something you DON'T want, if you want to keep baby arm stiff.

[shct]

Originally Posted by jmh80

Yeah.

Of course it does. Don't you see the C cups I have from my picture in my avatar????

jmh80,

if i send you a kilo of arginine, can you try for double Ds?

heh

shct