Clinically effective pharmaceutical grade herbal extracts

NeuroTropic

NeuroTropic

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Here's a list of proven effective herbal extracts.

Perika extract (WS® 5570) St John's Wort https://www.ncbi.nlm.nih.gov/pubmed/?term=WS+5570
EGb 761 brand of Gingko Biloba extract aka Ginkgold https://www.ncbi.nlm.nih.gov/pubmed/?term=EGb+761
Silexan aka Calmaid https://www.ncbi.nlm.nih.gov/pubmed/?term=Silexan
Zembrin Kanna extract https://www.ncbi.nlm.nih.gov/pubmed/?term=Zembrin

All clinically studied and all except Kanna approved by different governments for treating various health conditions.

Remember your long term health is important and clinically studied natural treatments "can" be a much safer and more effective superior alternative. Mode of action of any given drugs can give you all kinds of side effects or put you at risk of long term health issues. Many such issues do not exist in many natural treatments. An excellent example is Palmitoylethanolamide it's the ideal natural yet clinically proven substitute for NSAIDS but without any of the side effects. It's just a natural chemical in peanuts that acts to block inflammation, heal nerves, inhibit seizures, and reduce pain. But unlike NSAIDS won't give you a Heart Attack or Stroke because it works on the EndoCannabinoid system.
 

Irishobrien

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I have used the Kanna extract and it only worked once. Tachyphylaxis maybe
 

InItForGainz

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Out of curiosity, how effective is St John's Wort and how long does it take to actually kick in?
 

Irishobrien

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Out of curiosity, how effective is St John's Wort and how long does it take to actually kick in?
You can get an immediate buzz from SJW from a large dose. It’s been discussed on the old drugs-forum. Maybe type “st johns wort megadose” into google to find those old threads.
 
NeuroTropic

NeuroTropic

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Out of curiosity, how effective is St John's Wort and how long does it take to actually kick in?
As least as effective as SSRI's but safer.

Pharmacopsychiatry. 2006 Nov;39(6):213-9.
Comparison of Hypericum extract WS 5570 and paroxetine in ongoing treatment after recovery from an episode of moderate to severe depression: results from a randomized multicenter study.


To test and compare the efficacy and safety of Hypericum extract WS 5570 to paroxetine, a potent SSRI, in patients suffering from moderate or severe depression according to DSM-IV criteria.
METHODS:

In a multicenter, randomized, double-blind phase III study, the changes in moderate to severe major depression DSM-IV; 17-item Hamilton Depression Rating Scale (HAM-D total>or=22) after an acute treatment with Hypericum extract WS 5570 or paroxetine were analyzed in a 16-week continuation phase for relapse prevention. Patients with a HAM-D total score decrease of >or=50% during the 6 weeks of acute treatment were asked to continue the treatment for another 4 months. One-hundred and thirty-three adult out-patients who received maintenance doses of 900 (n=33) or 1800 mg/d (n=38) of WS 5570 and 20 (n=28) or 40 mg/d (n=34) of paroxetine, respectively, were included. The relevant dosage was already fixed during the acute treatment.

RESULTS:

Between baseline of the acute phase and end of continuation treatment the HAM-D total score decreased from 25.3+/-2.5 (mean+/-SD) to 4.3+/-6.2 points for WS 5570 and from 25.3+/-2.6 to 5.2+/-5.5 points for paroxetine (p=0.49, two-sided t-test; median relative decrease: 92.0 and 85.5%, respectively). During maintenance treatment alone (day 154-day 42), 61.6% of the patients randomized to WS 5570 and 54.6% treated with paroxetine showed an additional reduction (p=0.59) with respect to the HAM-D total score. Remission...occurred in 81.6%.. of the patients for WS 5570 and in 71.4%...for paroxetine (p=0.29). Three patients in the WS 5570 group and 2 patients in the paroxetine group showed a HAM-D increase>5 points during continuation treatment. In the continuation phase there were 0.006 adverse events per day of exposure for WS 5570 and 0.007 events for paroxetine.

CONCLUSION:

This study showed that WS 5570 and paroxetine were similarly effective in preventing relapse in a continuation treatment after recovery from an episode of moderate to severe depression and point therefore to an important alternative treatment option for long-term relapse-prevention.


BMJ. 2005 Mar 5;330(7490):503. Epub 2005 Feb 11.
Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine.

OBJECTIVE:

To investigate the efficacy of hypericum extract WS 5570 (St John's wort) compared with paroxetine in patients with moderate to severe major depression.
DESIGN:

Randomised double blind, double dummy, reference controlled, multicentre non-inferiority trial.
SETTING:

21 psychiatric primary care practices in Germany.
PARTICIPANTS:

251 adult outpatients with acute major depression with total score > or = 22 on the 17 item Hamilton depression scale.
INTERVENTIONS:

900 mg/day hypericum extract WS 5570 three times a day or 20 mg paroxetine once a day for six weeks. In initial non-responders doses were increased to 1800 mg/day hypericum or 40 mg/day paroxetine after two weeks.

MAIN OUTCOME MEASURES:

Change in score on Hamilton depression scale from baseline to day 42 (primary outcome). Secondary measures were change in scores on Montgomery-Asberg depression rating scale, clinical global impressions, and Beck depression inventory.

RESULTS:

The Hamilton depression total score decreased by mean 14.4 (SD 8.8) points, corresponding to 56.6%... in the hypericum group and by 11.4 (SD 8.6) points 44.8%... in the paroxetine group (intention to treat analysis; similar results were observed in the per protocol analysis). The intention to treat analysis (lower one sided 97.5% confidence limit 1.5 points for the difference hypericum minus paroxetine) and the per protocol analysis (lower confidence limit 0.7 points) showed non-inferiority of hypericum and statistical superiority over paroxetine. The lower limits in both cases exceeded the pre-specified non-inferiority margin of -2.5 points and the superiority margin of 0. The incidence of adverse events was 0.035 and 0.060 events per day of exposure for hypericum and paroxetine, respectively.

CONCLUSIONS:

In the treatment of moderate to severe major depression, hypericum extract WS 5570 is at least as effective as paroxetine and is better tolerated.
 
Cheeky Monkey

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Is Ginkgold even better than phenylpiracetam?
 
muscleupcrohn

muscleupcrohn

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Different. Far more clinical research compared to Phenylpiracetam.
Aside from the differences in the quantity of research on each, the effects/benefits are quite different. It’s almost comparing apples to oranges really.
 
NeuroTropic

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Aside from the differences in the quantity of research on each, the effects/benefits are quite different. It’s almost comparing apples to oranges really.
Mode of action yes but cognitive results would be an interesting medical journal review of the 2. You can read all the studies on my link above on one of the most clinically studied forms of gingko. Some are in healthy adults and interestingly an effective dose looks like at least 240 mg if not 600 mg daily. Many people suggest only 60-120 mg which seems low and potentially ineffective.
 
muscleupcrohn

muscleupcrohn

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Mode of action yes but cognitive results would be an interesting medical journal review of the 2. You can read all the studies on my link above on one of the most clinically studied forms of gingko. Some are in healthy adults and interestingly an effective dose looks like at least 240 mg if not 600 mg daily. Many people suggest only 60-120 mg which seems low and potentially ineffective.
I’m saying that the perceived effects, or how it feels, is not the same, even if both poses “nootropic” or “cognitive enhancing” benefits. I’m aware of the research on ginkgo, and I’m not knocking it’s effectiveness by any means. As far as further differences, ginkgo can be used daily, where phenylpiracetam shouldn’t be (at least based on many anecdotes if not actual research). Additionally, based on user feedback, phenylpiracetam is perhaps more suited/used for more “recreational” or “mood enhancing” benefits than cognitive enhancement per se. Not all racetams are the same, as I’m sure you know. Something like aniracetam has different benefits than piracetam or phenylpiracetam, so which racetam or nootropic ingredient comes out “on top” will likely depend on several factors. Including duration of supplementation, subject population, and parameters/variables evaluated.
 
NeuroTropic

NeuroTropic

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I’m saying that the perceived effects, or how it feels, is not the same, even if both poses “nootropic” or “cognitive enhancing” benefits. I’m aware of the research on ginkgo, and I’m not knocking it’s effectiveness by any means. As far as further differences, ginkgo can be used daily, where phenylpiracetam shouldn’t be (at least based on many anecdotes if not actual research). Additionally, based on user feedback, phenylpiracetam is perhaps more suited/used for more “recreational” or “mood enhancing” benefits than cognitive enhancement per se. Not all racetams are the same, as I’m sure you know. Something like aniracetam has different benefits than piracetam or phenylpiracetam, so which racetam or nootropic ingredient comes out “on top” will likely depend on several factors. Including duration of supplementation, subject population, and parameters/variables evaluated.
Oh certainly well said.
 

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