I have tried 5-HTP in many dosages and also in a time-release tablet. Taken in the daytime, it always put me in a brain fog and made me more likely to stay in the house/bed. Hence the reason it works fairly well in nighttime sleep formulas. Bottom line, I do not think it would be a successful choice. SAM-e could do wonders, or Lithium Orotate as far as natural supplements go.
Aside from that, energy always makes me feel so much better! Would she be up for running a bottle or two of OL IGNIT3? She would benefit from the SJW and the energizing/slightly euphoric effects that come with IGNIT3. Add this in with some cardio (if not already doing so) and she may start feeling much better before she knows it!