If you are doing lactic acid type training, you will want to avoid it pre workout and dose it all post, as glutamine (as well as creatine) has an overall alkaline effect on the body (if you believe in that type of thing). Any other type of training, I would split the dose pre and intra or post. Another (more expensive) alternative is to replace your carbs with equal amount of glutamine. This use would be incorporated if you were trying to reset insulin sensitivity, as it would aid in glycogen replenishment without as drastic of an insulin spike.