When a compound is alkylated (methyl or ethyl) at the carbon 17 there is an increase in liver stress due to creating a much harder to break down structure. It also results in near 100% bioavailability.
However, there are 7a and 3a methoxy analogs that are WAY LESS stressful on the liver than ANY 17a. It is like comparing asprin to Tylenol.
On another issue regarding androgenic potential and prostates: Lad, if you are experiencing ANY inflammation or hypertophy from ANY compound at age 21, you really need to seek medical evaluation.