Page 2 of 2 First 12

  1. chasec, Dr. D.

    Thanks for the welcome.

    We all have to do our parts to keep brotelligence in check.

    And this is a wonderful board, not to say that Avant isn't.

  2. Quote Originally Posted by mass_builder
    surfactants+ phosphotydlecholin = cell lysis

    Many results of many studies indicate that nonionic surfactants interact not only with proteins but also with membrane phospholipids by modifying their structure and permeability. As phospholipids are chemically simple compounds, the principles of various surfactant-phospholipid interactions and the character of forces involved are fairly well known.

    Surfactants generally increase the permeability of phospholipid membranes and vesicles, causing leakage of compounds with low molecular mass. The loss of ions, amino acids, etc., may result in cell damage or cell death. It is generally accepted that the increased permeability is the result of membrane disruption. Supramolecular surfactants (polyethylene glycol + dicarboxylic acid esters) as well as Triton X-100 readily disrupt egg yolk phosphatidylcholine membranes (32). An increase in permeability has been observed in many model systems: Triton X-100 and some new synthetic surfactants caused leakage from palmitoyloleoyl phosphatidylcholine/cholesterol vesicles, which are large and unilamellar (33). The concentration and aggregation state of surfactants also exert a considerable effect on their membrane-damaging capacity: monomeric Triton X-100 causes leakage of dipalmitoyl phosphatidylcholine vesicles, whereas micellar solutions result in the catastrophic rupture of membrane

    well i look into transdermal delivery of lecithin, its seams that phosphtidylecholin can be delivered systematicly, and localy since its amphiphilic.

    Localized and systemic drug delivery. Liposomes as drug carriers. Liposomes
    have shown great potential as novel drug carriers for
    dermal and transdermal systems. Liposomes are microscopic
    vesicles composed of membrane-like lipid layers surrounding
    an aqueous compartment (23). Phospholipids most often are
    used in the preparation of liposomes. Because of the amphiphilic
    nature of phospholipids, when they are dispersed in aqueous
    solutions they arrange in bilayers, with the fatty-acid tails
    (nonpolar) located in the membrane’s interior and the polar
    heads pointing outward. One of the advantages of using liposomes
    as drug carriers is that both lipophilic as well as hydrophilic
    drugs can be incorporated within the lipid bilayers and
    aqueous compartment, respectively. They also serve as a reservoir
    for the prolonged release of drugs within various skin
    layers (23–28), thereby reducing the rapid elimination of drug
    into the blood or lymphatic circulation (29). This quality makes
    the liposome delivery system useful for treating various skin
    disorders. Because they are nongreasy and nontacky, liposomal
    preparations are cosmetically acceptable.
    Various mechanisms have been proposed for the delivery of
    drugs through the skin using liposomes as a drug carrier. In
    these systems, liposomes carry a drug in dissolved form to the
    skin surface, and their lipid bilayer ruptures as a result !!!!!!
    Some great info, now do you know the proprietary ingredients in Limpo?

  3. Bump, This conversation just kinda fell off, Did you delute it with any thing, how is it now? I heard you need about four treatments to
    scuplt certain areas.

  4. Quote Originally Posted by DR.D
    Some great info, now do you know the proprietary ingredients in Limpo?
    WHat are they?

  5. If someone could PM me with info about PC from TLR I would appreciate it.


  6. I put in a hot water bath and shook it up. repeat as needed.

    It cleared it up for me.


Similar Forum Threads

  1. my phosphophatidylcholine log w/pics
    By TheGame46 in forum Anabolics
    Replies: 58
    Last Post: 05-19-2007, 04:17 PM
  2. Phosphophatidylcholine
    By TheGame46 in forum Anabolics
    Replies: 5
    Last Post: 11-01-2005, 08:07 PM
  3. Phosphophatidylcholine
    By TheGame46 in forum Anabolics
    Replies: 9
    Last Post: 03-19-2005, 09:58 AM
Log in
Log in