Insulin resistant individuals often have higher levels of BCAA due to reduced BCKD activity so not sure we can really make the conclusion that protein = insulin resistance by just showing people with insulin resistance have higher BCAA amounts. The increased BCAA observed can easily be an effect of being insulin resistant already.
Insulin resistant individuals often have higher levels of BCAA due to reduced BCKD activity so not sure we can really make the conclusion that protein = insulin resistance by just showing people with insulin resistance have higher BCAA amounts. The increased BCAA observed can easily be an effect of being insulin resistant already.
Very true and that's noted in the paper. But what about this:
In healthy subjects, fed for 6 month in energy balance, a diet high in protein (24 En%) compared with a normal protein diet (10 En%) induced a state of higher insulin resistance and glucose intolerance.33
Edit: I went to the referenced text and it stated that carb intake was substantially lower in the high protein group; this made me wonder if they realized that, when you lower carbs, you also increase insulin resistance so that the minimal amount you obtain through the diet is shuttled to areas of greatest need rather than to the muscles.
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