tybolton
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I know agmatine is awesome for pre workout, before bed and as a GDA. I dose 1 gram pre workout for endurance and pumps, and 1 gram before bed to help with sleep. I definitely notice a difference in my mood and general well being when I'm supplementing with it. What I didn't know was the strong neuro studies and its effect on stress, brain and depression. I found this article and related studies very interesting regarding agmatine.
See the article and studies here:
"Yangzheng et al. (2002) have speculated that agmatine reduces brain injury in neonatal rats exposed to hypoxia and ischemia as a result of its inhibitory effect on nitric oxide synthase. In addition, Gilad et al. (1996) found that agmatine is neuroprotective in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. Because of its multiple interactions with receptors and enzymes, agmatine represents a neurotransmitter that could increase in concentration during conditions such as cardiac arrest to prevent a variety of injurious brain activities. "
"Agmatine may offer protective benefits such as neuroprotection and anxiolysis in response to certain stressful conditions"
"Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells."
"Agmatine treatment is neuroprotective in rodent brain injury models."
"Antidepressant-like effect of agmatine and its possible mechanism."
See the article and studies here:
"Yangzheng et al. (2002) have speculated that agmatine reduces brain injury in neonatal rats exposed to hypoxia and ischemia as a result of its inhibitory effect on nitric oxide synthase. In addition, Gilad et al. (1996) found that agmatine is neuroprotective in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. Because of its multiple interactions with receptors and enzymes, agmatine represents a neurotransmitter that could increase in concentration during conditions such as cardiac arrest to prevent a variety of injurious brain activities. "
"Agmatine may offer protective benefits such as neuroprotection and anxiolysis in response to certain stressful conditions"
"Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells."
"Agmatine treatment is neuroprotective in rodent brain injury models."
"Antidepressant-like effect of agmatine and its possible mechanism."