Muscle Specific GDA

Page 2 of 2 First 12

  1. Interesting read on glucose lowering effects and increased glut-4 expression of isoleucine:

    0.45g/kg was the dose given. For a 70kg human that's 5.11 grams.

    Just bought some from nutrabio, so I'll run an experiment on my next carb up and update the thread.

    Recent investigations have revealed that the energy excess derived from amino acids activates mTOR and/or S6K1, which leads to insulin resistance (20, 21, 35). However, the single amino acid isoleucine decreases blood glucose through a si- multaneous increase in glucose utilization that actually im- proves glucose metabolism and energy states of both the muscle and liver (Fig. 8). Although the molecular basis of these findings remains to be determined, elucidation of the associa- tions related to these factors when using isoleucine may pro- vide new insights into the role of amino acids on metabolic disorders related to insulin resistance.

    In conclusion, our study revealed that isoleucine lowers blood glucose levels by both stimulation of the muscle glucose uptake and an increase in glucose oxidation within the whole body without significant elevation of plasma insulin levels. Our study also showed that isoleucine reduces hepatic glucose production in vitro and the expression and activity of hepatic gluconeogenic enzymes both in vitro and in vivo. By achieving a better understanding of the mechanism of isoleucine’s activ- ity, this may potentially provide important information relevant to the effects of amino acids on glucose metabolism.

  2. Quote Originally Posted by USPlabsRep View Post
    lifting weights increases AMPK
    lol, exactly. Better avoid ALCAR as well.
    PES - Physique Enhancing Science


Similar Forum Threads

  1. Replies: 4
    Last Post: 08-04-2010, 06:27 AM
  2. Muscle Milk
    By Sanosuke in forum Supplements
    Replies: 25
    Last Post: 04-13-2008, 08:00 PM
  3. Replies: 7
    Last Post: 06-17-2006, 02:27 PM
  4. whats your favorite muscle to train?
    By hamper19 in forum General Chat
    Replies: 22
    Last Post: 06-11-2005, 11:11 PM
  5. Exercise Phys.- Muscle Fiber Types
    By YellowJacket in forum Exercise Science
    Replies: 9
    Last Post: 12-12-2002, 11:42 AM
Log in
Log in