Pregnenolone long-term use...safe?
- 05-02-2014, 06:03 AM
Pregnenolone long-term use...safe?
Soooooo long story short, I got my wife some pregnenolone for her constant bitchiness. After the first dose she immediately turned back into the sweetheart I fell in love with. We are both astonished about how well and how fast it worked. I tried a pill today and I have to say I feel more clear-headed and I have had consistent energy all day, even more so than usual.
Anyway, knowing how well it works, we are both just wondering if it is safe to keep taking it indefinitely. I got her 10mg pills and one per day seems to be perfect. So here are a few questions.
Is it safe to take it every day, or should it be cycled? If it should be cycled, how long can she stay on it before cycling off it (and for how long should she cycle off of it)?
Are there any interactions with birth control?
Are there any negative sides we should watch out for? I googled and only read positive things, but it's also written everywhere that we don't completely understand it.
Can I take it also?
We are both around 30 years old if that counts. Thanks!
- 05-02-2014, 09:33 AM
I take it and it is recommended by my doctor and endo in addition to TRT. I backfilled with 50mg and now take 10mg a day. It is hands down, the best supplement next to actual test cyp. You are finding what almost everyone does. All day natural energy, wipes out anxiety, increased libido, mental clarity, and overall sense of well being.
My wife's doctor also recently recommended this to her because her DHEA and Prog levels were low, causing issues with anxiety, bad periods, and anger. It started working in 2 days and she is a different person already.
To your questions. Yes, it is very safe and it is natural. Your body produces it, but when we get older, the levels deplete. It won't hurt you, but it may be good to get tested to see where your levels currently are. Mine were low-normal and there is a 100% difference between low normal and high normal. The only thing to really watch out for is conversion to estrogen. Taking high doses 25mg+ can cause this to rise and bring on sides.
05-02-2014, 10:24 AM
05-02-2014, 10:36 AM
05-02-2014, 10:39 AM
05-02-2014, 10:41 AM
Nope, it is becoming the new standard protocol in hormone balancing and now that it is getting more attention, it seems to be better understood. If you are not low, you would not notice the benefits as much as you. Still, testing for it is always going to be a recommendation.
Backfilling was recommended by my endo and if you research it, is generally recommended. Build your levels back up and then maintain with low doses. I can go every other day with 10mg and be fine. If I need to be extra crisp, then I will take one every day.
Like I said, my wife had been to multiple doctors and they kept trying to go a script route that we did not want. So we sent her to a hormone specialist and they found her levels low. Scary to think about her going on prozac or some crap when it was her hormones that were out of whack.
05-02-2014, 11:47 AM
Another thing to consider is everyone is different and some like the effects of the cream and some like to take it orally. For me, taking a pill makes me feel spacy and not good. I love the cream though, as i feel great on it! It gives me energy and elevated mood, but i dont get the spacy feeling from it.
05-02-2014, 12:04 PM
05-02-2014, 12:46 PM
05-03-2014, 10:44 AM
We're looking at very low, mild doses here purely for the balance/well-being aspect, and as long as you feel it's helping I'd stay on it. If response ever becomes too lackluster, cycling off for at least a month will probably restore a lot of the effect when resumed.
05-03-2014, 01:55 PM
I am looking into taking 10mg daily as well. I am in my mid 30's and have experienced some declines in energy and mental clarity. Is there any difference between sublingual tabs or caps? The place I buy from only has 10mg caps right now.
Also, what is the best way to take it? With pre-meal, post meal, with food, without food, first thing AM, before bed PM, etc? Also any negative interaction with daily supps or noortropics such as Caffeine, Agmatine, CDP Choline, and Noopept?
05-03-2014, 02:05 PM
Buy from a different place and go sublingual. Take it in the morning upon waking and there is no negative interaction. It is a natural hormone that you already produce, but just likely at a much lower amount now that you are getting older.
05-03-2014, 02:06 PM
This all sounds great. I will be running a log using DHEA+preg from AgeForce. I am hoping to get the same good results.
05-03-2014, 02:27 PM
05-03-2014, 05:11 PM
05-04-2014, 02:11 AM
05-06-2014, 11:18 PM
05-06-2014, 11:33 PM
05-07-2014, 12:17 AM
I may be selling myself short by not using this daily. I experience anxiety pretty bad. I used transdermal preg and loved it
05-07-2014, 08:58 AM
Is it more GA than SA? Something to consider is upping your magnesium levels as well for a general state of calmness. Magnesium is great regardless, but it can really help GA.
05-07-2014, 11:11 AM
Preg partially converts to DHEA, but it may not be enough to bring levels to high norm. Supplementation with DHEA addresses that. It is usually recommended to start with preg and assess if DHEA is needed.
05-07-2014, 11:51 AM
That is up to you. I was working off of labs, so I knew what I was at and where I needed to be. I started with 50mg for 3 weeks and then dropped to 25, then to 10. Let me just say that I have never experienced anything like 50mg of preg. I'd take it at 6am and fly through my day until it finally started to taper off around 10-11pm. Then at about 3 weeks I could feel I was adjusting to it and lowered to a more manageable level.
Now that I am cruising at the top of the range in both preg and DHEA, if I take 20mg of preg, I get the same effect as when I first started. It can be fun as a recreational thing to go up for a day. We went on an 11mile hike the other weekend and nobody could keep up, but I kept it my secret. haha
05-07-2014, 12:20 PM
Well, all that would happen is it would normally end up converting to estrogen and you may get some insomnia. I could tell I was filled because at about 3 weeks, I started to break out. I backed it down and immediately cleared up.
05-07-2014, 12:53 PM
I am sure for therapy, under supervision, that could be true. Intramuscular response may be entirely different, too.
They don't call it the fountain of youth for no reason. I've yet to see anyone take it that didn't say it made their lives better.
05-08-2014, 01:35 PM
If taking at 10mg daily without back loading, is it still possible to build back up the body's normal to high normal range?
05-09-2014, 12:08 AM
05-09-2014, 02:23 AM
I would advise to start low and then go up slowly and see how you like the effects. Some people have heart palpitations when they dose to high. And don't forget to try transdermal, which works WAY better at least for me. One pump of the brand I use is equal to 15 mg...and I "try" and pump out more like 5 mg worth, give or take. I've done a lot of looking around the internet on the use of preg, and I tend to agree that someone in their 30's would probably be happy with equal to/or less than 5 mg. And this is with a day or two off a week, and a more extended hormone "holiday" from time to time. Good stuff!
05-09-2014, 08:05 AM
05-09-2014, 08:07 AM
05-09-2014, 09:52 AM
But, I am confused. What does ZMA, remembering if you had anxiety, and pregnenolone have to do with one another?
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