Higher ArA dosage, or ArA stack?

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    Quote Originally Posted by BPjohn123 View Post
    They would stack very well
    Yup. As pointed out by @EBF Inc

    Quote Originally Posted by EBF Inc View Post
    COX and LPO breakdown the ArA into the luekotrienes and thromboxanes

    Inhibiting them (5-LPO and COX-2 inhibitor) leaves more Arachidonic acid available for uptake into muscle cells. This would be a good thing.
    So when we take ArA some of it gets broken down into luekotrienes and thromboxanes via LPO and COX. Now if we could inhibit both of them it would result in more ArA to stay which meams there is more that could be used by our muscles

    So the proposed above stack would inhibit ArA being broken down into thromboxanes via l-carnitine ( http://ajpheart.physiology.org/content/284/1/H41) and inhibit ArA being broken down into luekotrienes via anabeta elite (http://www.ncbi.nlm.nih.gov/pubmed/15938197)

    So l-carnitine and anabeta elite would create the enviroment for optimal available ArA.

    Now also, as pointed out by @EBF Inc

    Quote Originally Posted by EBF Inc View Post
    This may also be where garcinia Cambogia (50% hca) can play into effect in the cellular uptake but via a different mechanism (CD36).
    So we add HCA to help all that now extra ArA to be able to get used by our muscles

    Hence the stack of ArA + Anabeta Elite + l-carnitine + metabolic powder
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    Quote Originally Posted by JudoJosh View Post

    Hence the stack of ArA + Anabeta Elite + l-carnitine + metabolic powder

    And so you'd reccomend this all pre-workout? Aren't ABE & MP meant to be taken with food?
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    Quote Originally Posted by MultiVitamin View Post
    And so you'd reccomend this all pre-workout? Aren't ABE & MP meant to be taken with food?
    ABE is recommended pre-workout. MP is also recommended pre-workout. Both can be taken with or without food.
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    Quote Originally Posted by kbayne View Post
    ABE is recommended pre-workout. MP is also recommended pre-workout. Both can be taken with or without food.
    Okay thanks man
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    That's from this thread son!
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    oops,my bad
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    Quote Originally Posted by aaronuconn View Post
    How about just the leucine then...
    Yes, that would be fine.

    Quote Originally Posted by EBF Inc View Post
    Can you give a partial or full explanation as I'm curious as well
    Short on time, but I will get into it later if I remember. I'm sure Cyrus or someone else can explain if they have time (assuming they're asked nicely ).
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    Quote Originally Posted by Synapsin View Post
    Yes, that would be fine.



    Short on time, but I will get into it later if I remember. I'm sure Cyrus or someone else can explain if they have time (assuming they're asked nicely ).
    I'll be sending constant messages.

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    Quote Originally Posted by Synapsin View Post

    Yes, that would be fine.

    Short on time, but I will get into it later if I remember. I'm sure Cyrus or someone else can explain if they have time (assuming they're asked nicely ).
    I actually just read a study while I was searching showing some sort of blunted effects in the presence of insulin maybe on the prostaglandin formation. **** I wish I remembered
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    From what I can tell from reading information Neuron has posted:

    arachidonic acid --> triglyceride --> chylomicron --> interaction with enzyme Lipoprotein Lipase (LPL) --> "only isoform of LPL that is active with insulin is located on adipocytes".

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    Quote Originally Posted by aaronuconn View Post
    From what I can tell from reading information Neuron has posted:

    arachidonic acid --> triglyceride --> chylomicron --> interaction with enzyme Lipoprotein Lipase (LPL) --> "only isoform of LPL that is active with insulin is located on adipocytes".
    Did he say that last statement? Both forms are active but the adipose form predominates with insulin
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    Quote Originally Posted by mr.cooper69 View Post
    Did he say that last statement? Both forms are active but the adipose form predominates with insulin
    It's from his first post on the Maximizing AA to skeletal muscle on bb.com.

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    Here's the entire first post from Neuron on the aforementioned thread:

    "I made a cursory glance into the X-Factor thread and I didn't see any suggestion on when to take X-Factor, or other Arachidonic acid products, so here is my suggestion.

    Background
    After ingestion, fatty acids like arachidonic acid are emulsifed and taken up into enterocytes where they are esterfied on a glycerol backbone to form a triglyceride. Next, the triglycerides and cholesterol esters are bound together to form a chylomicron. This entity can now diffuse into the lymphatics and then into the blood. Once in the blood, the chylomicrons are free to interact with various tissue receptors depending on energy homeostasis. When needed, they can interact with an enzyme called Lipoprotein Lipase (LPL) that will hydrolyze the triglycerides back into fatty acids to be used as fuel or for storage purposes.

    The point being...
    In which tissue the fatty acids are deposited is a function of the energetic state of the organism overall. In a post-prandial, high fed, state, the dominant hormone is insulin. Similarly, the only isoform of LPL that is active with insulin is located on adipocytes. It should be obvious now that consuming fats when eating will direct them to adipose. This isn't necessarily a bad thing in the context of fish oil, as adipose is now recognized as a great contributer to endogenous hormone production like the prostanoids.

    But...
    In the context of Arachidonic Acid, the final destination should be skeletal muscle. Luckily, there is an energetic state which favors fatty acid delievery to this tissue: Exercise (or acute starvation) [1]. In an exercise-induced environment, LPL on skeletal muscle becomes active which serves as an adjunct to glycolysis for the TCA cycle via beta-oxidation. Similarly, the enzyme DGAT also becomes active in skeletal muscle which functions to store excess fatty acids as triglycerides. Since both of these enzymes are heavily active during exercise, it is clear that an excess of fatty acids are being removed from blood plasma into skeletal muscle as a reservoir (this also serves to decrease insulin insensitivity [2]).

    Based on these observations
    To maximize ArA supplemention it is advisable to supplement 30-40 minutes prior to exercise in order to ensure plasma delievery of ArA and also to reduce exercises effects on gastric motility."

    [1] http://ajpendo.physiology.org/cgi/co...act/268/2/E229
    [2] http://ajpendo.physiology.org/cgi/co...act/294/5/E882
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    Happy to hear that the stack I'm starting in a couple of weeks should be pretty kick ass.

    ArA + ABE + GMS + LCLT. (maybe Amino IV, too)
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    Yeah, I make sure to take 1.5gms at least 45 minutes to an hour before I work out.
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    Quote Originally Posted by doggy_dog View Post
    Happy to hear that the stack I'm starting in a couple of weeks should be pretty kick ass.

    ArA + ABE + GMS + LCLT. (maybe Amino IV, too)
    I'm doing the same stack, starting in mid Feb
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    Quote Originally Posted by doggy_dog View Post
    Happy to hear that the stack I'm starting in a couple of weeks should be pretty kick ass. ArA + ABE + GMS + LCLT. (maybe Amino IV, too)
    Throw some Agmatine in too
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    Quote Originally Posted by Misfit28 View Post
    Throw some Agmatine in too
    Pumps would hurt too much lol (kinda srs)
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    Quote Originally Posted by kbayne View Post
    Pumps would hurt too much lol (kinda srs)
    Lol, may get counterproductive.

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    Quote Originally Posted by kbayne View Post
    Pumps would hurt too much lol (kinda srs)
    Good point! I've just recently fallen in love with Agmatine. Not just the pump aspect (which is awesome), but the neurological/mood effects for me
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    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
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    Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    It's uptake into adipose. Insulin facilitates it I believe
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    Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    Drop the carbs if possible and dose Ara completely fasted
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    Im running ArA with Glycergrow & hemoval and ABE, except ive been dosing ABE with my biggest meals... gotta start dosing PWO I suppose
    http://anabolicminds.com/forum/powerlifting-strongman/240580-road-derby-cup.html
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    Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    As Jiigzz stated, I would drop the Glycofuse pre-workout and dose your ArA fasted.
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    Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    save the carbs for postWO or eat slightly more carbs with other meals if worried about losing those carbs/calories in order to maximize your ArA

    Darren and NP are too awesome, still selling X-Factor and XFA for right around $30!

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    Quote Originally Posted by SwolenONE View Post

    save the carbs for postWO or eat slightly more carbs with other meals if worried about losing those carbs/calories in order to maximize your ArA

    Darren and NP are too awesome, still selling X-Factor and XFA for right around $30!

    http://www.nutraplanet.com/product/m...-softgels.html
    Or use FORSKOLIN with ara

    Start training. Wait till set 4-8 and then start your carbs
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    Quote Originally Posted by EBF Inc View Post
    Or use FORSKOLIN with ara

    Start training. Wait till set 4-8 and then start your carbs
    I just picked up some Forskolin 50.

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    Is there a time frame after taking ARA where carbs shouldn't be consumed? 2-3 hours or less?
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    Quote Originally Posted by Johnston View Post
    Is there a time frame after taking ARA where carbs shouldn't be consumed? 2-3 hours or less?
    Well start training this way phospholipase a2 does its job and ara get to those muscle cells. After that I don't see a reason to avoid carbs IMO

    Use the FORSKOLIN to prevent any ara dependant adipocyte differentiation (when insulin is present).
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    Quote Originally Posted by Johnston View Post
    Is there a time frame after taking ARA where carbs shouldn't be consumed? 2-3 hours or less?
    I still keep my intra workout carbs in place
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    Quote Originally Posted by Jiigzz View Post

    I still keep my intra workout carbs in place
    So do I I just start drinking between sets 4 and 8
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    Quote Originally Posted by EBF Inc View Post
    Well start training this way phospholipase a2 does its job and ara get to those muscle cells. After that I don't see a reason to avoid carbs IMO

    Use the FORSKOLIN to prevent any ara dependant adipocyte differentiation (when insulin is present).
    Carbs are avoided to keep a higher relative activity of LPL in muscle vs fat (nothing to do with PLA2).

    But for the last time (and I mean the last time, not to you EBF, but to people asking the Qs as I've probably said this 25+ times now in the past month), if you are exercising, carbs/amino acids consumed with ArA won't matter. So take them all preworkout if you want and get to it
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    Any thoughts on ARA/forskokin combo in PCT?
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    Quote Originally Posted by JD261985 View Post
    Any thoughts on ARA/forskokin combo in PCT?
    It would be fantastic for maintaining gains and body composition in general
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    Quote Originally Posted by mr.cooper69 View Post

    Carbs are avoided to keep a higher relative activity of LPL in muscle vs fat (nothing to do with PLA2).

    But for the last time (and I mean the last time, not to you EBF, but to people asking the Qs as I've probably said this 25+ times now in the past month), if you are exercising, carbs/amino acids consumed with ArA won't matter. So take them all preworkout if you want and get to it
    You don't think the pla2 will make sure the uptake of ara goes to muscle instead of adipose?
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    Quote Originally Posted by mr.cooper69 View Post
    Carbs are avoided to keep a higher relative activity of LPL in muscle vs fat (nothing to do with PLA2).

    But for the last time (and I mean the last time, not to you EBF, but to people asking the Qs as I've probably said this 25+ times now in the past month), if you are exercising, carbs/amino acids consumed with ArA won't matter. So take them all preworkout if you want and get to it
    Great info.

    Would be cool to see a supp with forskolin and Arachidonic Acid in it!
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    Quote Originally Posted by SwolenONE View Post

    Great info.

    Would be cool to see a supp with forskolin and Arachidonic Acid in it!
    I have a better idea!


    easy enough to add FORSKOLIN to the cart without increasing the cost of the product
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    Quote Originally Posted by EBF Inc View Post
    I have a better idea!


    easy enough to add FORSKOLIN to the cart without increasing the cost of the product
    I agree, this issue is loss of flexibility. If you want 6 or 8 caps of ArA preworkout, you now have to **** yourself, literally
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