Serotonin & Dopamine...

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  1. Quote Originally Posted by Aleksandar37 View Post

    Do you happen to have a pdf of the study? I see what the abstract says happens in retinal cells, but even then it is not clear. Pregenolone modulate NMDARs, but I haven't seen anything that shows that synthesis occurs after NMDAR activation.
    I can snag it when I get home. But the abstract says the synthesis increases after NMDAR activation.


  2. Quote Originally Posted by Vj63 View Post
    You SNS guys make some great points about seeking medical advice for these things. In fact, to show my appreciation, I will consult a physician before taking any of your products just as you advise. I know that my doctor as well as most others will be eager to give me their blessing to take products that are widely known by most MDs like DAA, agmatine, x-gels.
    Thanks so much for caring.
    would you rather them be like the iforce reps and constantly pimp every iforce supp for every question lol?
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  3. Quote Originally Posted by EatMoar View Post
    I can snag it when I get home. But the abstract says the synthesis increases after NMDAR activation.
    Abstracts have a funny tendency to sound much more exciting and significant than the data actually shows. Also, the abstract says they only used retinal cells.
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  4. Quote Originally Posted by Alasel View Post
    I was actually reading up on a l-dopa supplement as I believe it also has growth hormone elevating properties which i was looking for a separate supplement for also. What kind of dowse would be use for dwell good and what dose for gh elevation?

    Thanks for you response
    2 caps of analyzed supplements dopadex should definitely do the trick, you could add a little huperzine-a to attentuate the effects
    doing my own thang!

  5. Quote Originally Posted by Aleksandar37 View Post
    OP, my recommendation for the winter months is vitamin D3. If you're looking for a quality L-Dopa product, I would check out Dopadex http://www.nutraplanet.com/product/s...x-90-caps.html
    i agree, vitamin d is great for mood enhancement and aids in dopamine + serotonin synthesis
    doing my own thang!

  6. Quote Originally Posted by rhoadx View Post
    would you rather them be like the iforce reps and constantly pimp every iforce supp for every question lol?
    This. Products like x-gels, agmatine, etc, aren't used to treat issues that may be as serious as mental health issues, regardless of how insignificant the OP and others may think they are. I would have thought that people would prefer helpful responses by people that aren't just out to pimp products for the sake of helping the bottom line out.

  7. spicy thread is spicy

    Quote Originally Posted by Synapsin View Post
    I would have thought that people would prefer helpful responses by people that aren't just out to pimp products for the sake of helping the bottom line out.
    nahh -- everyone has an agenda
    that's just how sh1t works




    Quote Originally Posted by EatMoar View Post
    I can snag it.
    the hell you say..I wanna see that

  8. Quote Originally Posted by Synapsin View Post
    This. Products like x-gels, agmatine, etc, aren't used to treat issues that may be as serious as mental health issues, regardless of how insignificant the OP and others may think they are. I would have thought that people would prefer helpful responses by people that aren't just out to pimp products for the sake of helping the bottom line out.

    lmao, i don't even know how to respond to this nonsense...i'll just let it go

  9. Quote Originally Posted by Young Gotti View Post
    lmao, i don't even know how to respond to this nonsense...i'll just let it go
    What's nonsense about it? Agmatine is a confirmed neurotransmitter in the human body and ArA excess is implicated in all sorts of neurological conditions.

  10. Quote Originally Posted by Jiigzz View Post
    What are you talking about Aaron? Of course we know more than a medical professional. I googled supplements to help depression for a FULL 5 minutes today In all seriousness, vitamin d3 supplementation is my preferred supplement of choice to 'prevent' seasonal depression. That and l dopa. I like l dopa
    This illustrates just how correct you are about giving advise.

    My wife is an endocrinologist. I also had to learn about treatment of osteoporosis back when we tried 7 HRT bellwether cases in Reno and in Philadelphia. Understanding D3 was a piece of this process.

    The feel good from the sun comes from an opioid B-endorphin via stimulation of POMC. Not sure D really produces any feel good reaction similar to the UV production of B-endorphin feel good response.

    The belief that large doses of d will make a normal person feel any better or any different is perhaps bunk. Large doses of D3 theoretically could have opposite impact if raises blood calcium. I think the d feel good may be a bit psychosomatic.

    A lot of us eating decent amounts of tuna, salmon and etc. and with younger skin may be at optimal levels. Taking mega doses with optimal levels may lead to hypercalcemia. K may help plumbing and redirect calcium.
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  11. 5htp - legendary, make sure its a good supplier and start low (50mg) increasing if needed. ALWAYS perks me up when im being a grumpy a$$ this time of year. Within 2 weeks you forget the need for it.

    Also, if stressed, try some calming - Im grumpy from that too - so I take Kalms or other supermarket versions

    L-dopa arrived today! A MUST for 5htp users as it depletes dopamine. Together, you feel GREEEEAAAT. I couldn't wait for my usa shipment so I bought USP Powerfull from the uk.


    Don't go to the doc, he'll refer you for chemicals that don't fix the issue or natural option will be 5htp anyway!

  12. Quote Originally Posted by infraredline View Post
    I disagree, if he seeks medical help they are just going to put him on something like Lexapro or Prozac which are just going to cause more of a problem.
    Well said!

  13. Quote Originally Posted by Clean gene View Post
    Well said!
    I agree that many times SSRIs are handed up absent proper testing resulting in an exacerbation of the problem, especially if the problem is xy axis related. Docs are getting a little better these days regarding the SSRIs.

    Telling someone (especially younger white males) to take D3 without knowing their baseline, however, is perhaps no better than a GP prescribing an SSRI to someone depressed because of jacked hormones. Even with baseline tests, a low D and high blood calcium could be indicative of a parathyroid. Low D3 prohibits intestines from absorbing more calcium to protect the body from high blood calcium levels. Ingesting more D3 could be very, very bad even if you have low D-25 without a full understanding of the bigger picture.

    The point here is that a healthy younger individual eating a proper diet will generally have homeostasis with D3 and calcium levels. The lower range D25 blood level was also recently reduced from 30ng to 20ng. I doubt very seriously most, if any of you, need or will benefit from D supplements if you are less than 30, male, or non-Hispanic white. Candidly, unless you are some 65 year old granny with jacked hormones, have Parkinson's, MS et al., vitamin D will perhaps do nothing for you. So much misinformation or manipulation of data employed to promote D.

  14. Quote Originally Posted by 996ttelise View Post

    I agree that many times SSRIs are handed up absent proper testing resulting in an exacerbation of the problem, especially if the problem is xy axis related. Docs are getting a little better these days regarding the SSRIs.

    Telling someone (especially younger white males) to take D3 without knowing their baseline, however, is perhaps no better than a GP prescribing an SSRI to someone depressed because of jacked hormones. Even with baseline tests, a low D and high blood calcium could be indicative of a parathyroid. Low D3 prohibits intestines from absorbing more calcium to protect the body from high blood calcium levels. Ingesting more D3 could be very, very bad even if you have low D-25 without a full understanding of the bigger picture.

    The point here is that a healthy younger individual eating a proper diet will generally have homeostasis with D3 and calcium levels. The lower range D25 blood level was also recently reduced from 30ng to 20ng. I doubt very seriously most, if any of you, need or will benefit from D supplements if you are less than 30, male, or non-Hispanic white. Candidly, unless you are some 65 year old granny with jacked hormones, have Parkinson's, MS et al., vitamin D will perhaps do nothing for you. So much misinformation or manipulation of data employed to promote D.
    This probably needs a cooper or synapsin response but remember there is vitamin D and vitamin D3 supplements and,during colder winter months it should be almost mandatory to get extra d3 in the system considering the sun is the main source of it.

    The safe UL is noted at around 10,000iu and there are so many benefits with supplementing with d3, if deficiet, that doing so in winter should be paramount.

    Can I ask you what basis you lay the claim that supplementing with it is not needed given the plethora of data on the subject showing benefits?
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  15. Quote Originally Posted by Jiigzz View Post
    This probably needs a cooper or synapsin response but remember there is vitamin D and vitamin D3 supplements and,during colder winter months it should be almost mandatory to get extra d3 in the system considering the sun is the main source of it.
    Almost mandatory? According to whom? Supplement companies, vitamin companies, health food stores, homeopathic companies et al. I do know a few DOs and GPs that used to make such statements, but have since backed off.

    In healthy individuals, blood levels of cholecalciferol naturally peak in the fall, build up in your system and help production of d throughout the winter months. Again, if you are a young, white male that ingests a healthy diet, you are most likely in a state of homeostasis with regard to d and calcium regulation throughout the winter months.

    Unlike the body's conversion of sun, taking d supplements can cause hypercalcemia. The body will down regulate D in a state of hypercalcemia to impede the small intestine's absorption of more calcium to guard against further hypercalcemia. The body can and will maintain this homeostasis with natural d production, but cannot with supplemental vitamin d.

    Guess what? Hypercalcemia due to unnecessary ingestion of supplemental d can cause: depression, memory loss, apathy and irritability.

    I primarily took issue with your feel good comments regarding taking supplemental d. The feel good reaction from the sun is not a result of vitamin d. The sun's feel good comes from an opioid B-endorphin through stimulation of POMC.

  16. Quote Originally Posted by 996ttelise View Post
    So much misinformation or manipulation of data employed to promote __________.
    I know you put "vit D" in there when you typed it, but let's just be real and fill in the blank with whatever you want
    this forum is great, but ppl sure stretch the credibility of this or that study etc when attempting to "prove a point"
    I get a chuckle almost daily

  17. Quote Originally Posted by 996ttelise View Post

    Almost mandatory? According to whom? Supplement companies, vitamin companies, health food stores, homeopathic companies et al. I do know a few DOs and GPs that used to make such statements, but have since backed off.

    In healthy individuals, blood levels of cholecalciferol naturally peak in the fall, build up in your system and help production of d throughout the winter months. Again, if you are a young, white male that ingests a healthy diet, you are most likely in a state of homeostasis with regard to d and calcium regulation throughout the winter months.

    Unlike the body's conversion of sun, taking d supplements can cause hypercalcemia. The body will down regulate D in a state of hypercalcemia to impede the small intestine's absorption of more calcium to guard against further hypercalcemia. The body can and will maintain this homeostasis with natural d production, but cannot with supplemental vitamin d.

    Guess what? Hypercalcemia due to unnecessary ingestion of supplemental d can cause: depression, memory loss, apathy and irritability.

    I primarily took issue with your feel good comments regarding taking supplemental d. The feel good reaction from the sun is not a result of vitamin d. The sun's feel good comes from an opioid B-endorphin through stimulation of POMC.
    Cooper is a, at least to my knowledge, a proponent of supplemental vit D3.
    @mr.cooper69 @Synapsin @De__eB

    If this is true, which the overwhelming doesnt support, then I want to hear it from these guys.
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  18. Quote Originally Posted by snagencyV2.0 View Post
    I know you put "vit D" in there when you typed it, but let's just be real and fill in the blank with whatever you want
    this forum is great, but ppl sure stretch the credibility of this or that study etc when attempting to "prove a point"
    I get a chuckle almost daily
    You're being ignorant if you feel all studies are biased to make you buy product.
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  19. Quote Originally Posted by Jiigzz View Post
    You're being ignorant if you feel all studies are biased to make you buy product.
    what? jigzz, I am shocked by your own lack of thought in that post
    where the hell did I say anything remotely resembling what you accuse me of?
    I think you need some sleep buddy

  20. Quote Originally Posted by mr.cooper69 View Post
    What's nonsense about it? Agmatine is a confirmed neurotransmitter in the human body and ArA excess is implicated in all sorts of neurological conditions.
    I know eh? I saw his post and figured no point in getting into a pointless argument.

    About vit D: people tend to be more deficient than they think, but not everybody is and its quite easy to take care of. Vit D should realistically be taken by people who have had blood tests showing they are deficient, although it won't hurt most people to supplement vit D. Supplementing it when you don't need it, however, is pointless.

  21. Quote Originally Posted by Jiigzz View Post
    Cooper is a, at least to my knowledge, a proponent of supplemental vit D3.
    @mr.cooper69 @Synapsin @De__eB

    If this is true, which the overwhelming doesnt support, then I want to hear it from these guys.
    Toxicity from Vit D requires an incredibly high dose, but Hypercalcemia is certainly possible at realistic doses (especially if combined with supplementing calcium). It's pretty rare though.

  22. Quote Originally Posted by snagencyV2.0 View Post
    what? jigzz, I am shocked by your own lack of thought in that post
    where the hell did I say anything remotely resembling what you accuse me of?
    I think you need some sleep buddy
    Thought you were digging at me with that post is all.

    I've been slammed a bit in the training world for citing studies on various things only to have people throw in similar comments.
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  23. Quote Originally Posted by Jiigzz View Post
    This probably needs a cooper or synapsin response but remember there is vitamin D and vitamin D3 supplements and,during colder winter months it should be almost mandatory to get extra d3 in the system considering the sun is the main source of it.

    The safe UL is noted at around 10,000iu and there are so many benefits with supplementing with d3, if deficiet, that doing so in winter should be paramount.

    Can I ask you what basis you lay the claim that supplementing with it is not needed given the plethora of data on the subject showing benefits?

    What data, studies on 50 to 70 year old women???

    Seriously, you would recommend a healthy, young white male with normal D 1,25 levels take 10,000 ius a day? Kind hurts your credibility as to any recommendations. Those doses are contemplated for geriatric women with severe deficiencies and an inability to convert naturally and 10,000 ius and 10,000 ius can potentially cause hypervitaminosis.

    Data . . . Read my last post so you can perhaps understand why supplemental d can cause hypercalcemia whereas natural conversion of sunlight will not cause hypercalcemia and throw body out of a state of homeostasis as far as regulation of serum calcium levels.

  24. Quote Originally Posted by 996ttelise View Post

    What data, studies on 50 to 70 year old women???

    Seriously, you would recommend a healthy, young white male with normal D 1,25 levels take 10,000 ius a day? Kind hurts your credibility as to any recommendations. Those doses are contemplated for geriatric women with severe deficiencies and an inability to convert naturally and 10,000 ius and 10,000 ius can potentially cause hypervitaminosis.

    Data . . . Read my last post so you can perhaps understand why supplemental d can cause hypercalcemia whereas natural conversion of sunlight will not cause hypercalcemia and throw body out of a state of homeostasis as far as regulation of serum calcium levels.
    I didnt say their levels were normal. Theres no way I could know that. But vit d supplementation is very common
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  25. Quote Originally Posted by snagencyV2.0 View Post
    I know you put "vit D" in there when you typed it, but let's just be real and fill in the blank with whatever you want
    this forum is great, but ppl sure stretch the credibility of this or that study etc when attempting to "prove a point"
    I get a chuckle almost daily
    gotta love this place

  26. I have to admit that during my current 'cycle' of DOPADEX I've not only had some of the best sleep (and most intense dreams) of my life but my mood has been amazing. I feel positive and generally have a real spring in my step.

    The sex life is also reaping the rewards :P

    I can highly recommend this product from my own experiences.
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  27. Quote Originally Posted by Synapsin View Post

    I know eh? I saw his post and figured no point in getting into a pointless argument.

    About vit D: people tend to be more deficient than they think, but not everybody is and its quite easy to take care of. Vit D should realistically be taken by people who have had blood tests showing they are deficient, although it won't hurt most people to supplement vit D. Supplementing it when you don't need it, however, is pointless.
    Thanks synapsin. Appreciate the input
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  28. Quote Originally Posted by Synapsin View Post
    Toxicity from Vit D requires an incredibly high dose, but Hypercalcemia is certainly possible at realistic doses (especially if combined with supplementing calcium). It's pretty rare though.
    Hypothetically, do you disagree that 10,000 ius a day could potentially cause hypercalcemia in a 30 year old, white male on a healthy diet that has normal D 1,25 levels and normal serum calcium without the additional d supplementation?

    I primarily responded to note that the feel good effect from sun has little or nothing to do with vitamin d and more to do with an opioid B-endorphin stimulation.

    I, however, do feel that people on here are using studies or data completely unrelated to healthy white young males to promote use of something that may not be needed and that could potentially cause problems.

    Get blood work including D 1,25, calcium and maybe PTH, before ingesting 5,000 or 10,000 ius of d3 a day.

  29. Quote Originally Posted by Jiigzz View Post
    Thanks synapsin. Appreciate the input
    Any time.

    Quote Originally Posted by 996ttelise View Post
    Hypothetically, do you disagree that 10,000 ius a day could potentially cause hypercalcemia in a 30 year old, white male on a healthy diet that has normal D 1,25 levels and normal serum calcium without the additional d supplementation?

    Get blood work including D 1,25, calcium and maybe PTH, before ingesting 5,000 or 10,000 ius of d3 a day.
    Yes, it is certainly possible. It would be rare but it can definitely happen, especially if they have any other relevant health issues. I personally supplement 10k IU in the Winter, but its because I test myself and I spend most of the day indoors. Like I said, you shouldn't supplement it if you don't know you're deficient in it.

  30. Quote Originally Posted by 996ttelise View Post
    Hypothetically, do you disagree that 10,000 ius a day could potentially cause hypercalcemia in a 30 year old, white male on a healthy diet that has normal D 1,25 levels and normal serum calcium without the additional d supplementation?

    I primarily responded to note that the feel good effect from sun has little or nothing to do with vitamin d and more to do with an opioid B-endorphin stimulation.

    I, however, do feel that people on here are using studies or data completely unrelated to healthy white young males to promote use of something that may not be needed and that could potentially cause problems.

    Get blood work including D 1,25, calcium and maybe PTH, before ingesting 5,000 or 10,000 ius of d3 a day.
    I dose 10,000 IU of VD3 mon-fri and have done so for... probably years now. I'm just shy of turning 30 myself.

    No health issues and only positive things to report. I think most people are D3 deficit without even knowing it and supplementing with it is a great idea. Should be a staple imho... oh, and FWIW I'm in Australia so not exactly short of the sunshine down here.
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