- 05-12-2013, 09:39 AM
N-ethyl-1-phenyl-butan-2-amine is a synthetic methamphetamine analog not listed on the label of craze. As a designer stimulant it would not be explicitly classified as illegal. So the statement you highlighted is obvious.
This is the same situation as bath salts. In fact, the only difference between this and bath salts is the marketing and labelingAnabolicminds.com Featured Author
- 05-12-2013, 09:41 AM
05-12-2013, 10:14 AM
Never seen you this reckless when making statements before. Not defending DS or anything personally i think craze is pure **** but there is a huge difference between said compound above and substituted cathinones normally contained in bath salts, pharmacologically to say the least
05-12-2013, 10:32 AM
i said same situation as bath salts. as in legally the stuff is essentially in same class as bath salts. that was my point.
I was not referring to nuances of pharmacology, and I dont think anyone quite knows the pharmacology of this designer stuff anyway. Its pretty apparent that it is stronger than anything available that is natural though
Anabolicminds.com Featured Author
05-12-2013, 12:39 PM
Im not familiar with the compound, there is no scientific research behind it. But based on structure activity relationship of the many phenethylamines(cathinones and amphetamines) that have been released for recreational use, the available scientific data suggests that large alkyl substituents at the alpha position drastically decreases dopaminergic activity.
Bulky nitrogen terminal substituents decrease both affinity of monoamine oxidase and the vehicular monoamine transporter which in turn decreases the monoamine releasing properties.
The above compound is most likely simply a noradrenergic releasing agent through VMAT inhibition
Cathinones on the other hand have shown significant activity as a serotonin releasing agent, similar mechanism as MDMA, and an extremely large variation of other properties depending on how its substituted on the phenyl ring. Effects ranging from MAOI, reuptake inhibition, releasing agents to direct excitotoxic effects. Cathinones also have zero affinity for the trace amine receptor, whether its relevant or not i have no idea.
Basically its like comparing ephedrine to methamphetamine in terms of activity, even though legally its the same
05-12-2013, 03:35 PM
Buphedrone has an alpha ethyl and is quite dopaminergic. Pentedrone has an alpha-propyl alkyl group and is also dopaminergic.
Large N-alkyl substituents are great for their MOA enzymatic proclivity and MOA inhibiton (N-propyl >> N-ethyl >>> N-methyl), which is the opposite of what you stated. Furthermore, N-alkyl length has almost no importance when discussing monoamine transporter activity.
I'm going to stop there, because you are clearly clueless.
05-12-2013, 03:38 PM
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