- 03-11-2013, 12:08 AM
- 03-11-2013, 01:12 AM
03-11-2013, 01:21 AM
03-11-2013, 01:35 AM
Weight Loss, Exercise And Health Research - Carrie P. Saylor - Google Books
Note that aromatase activity is very low in skeletal muscle (and much higher in adipose tissue) so you don't have to be concerned in this regard. Just thought it was cool stuff
03-11-2013, 03:43 AM
It would appear that inhibiting estrogen activity either by aromatase or direct antagonism is counter productive for fat loss. The articles i came across used aromatase, estrogen receptor and androgen receptor knockout mice. Some were gender specific and others were not.
Aromatase and estrogen receptor knockout mice(males + females) showed greater fat accumulation, both visceral and peripheral. They also had increased insulin sensitivity and reduced leptin secretion. Androgen receptor knockout mice showed slight fat accumulation but also a large increase in lipase(and probably downstream increase in UCP) but they had normal insulin sensitivity and LPL levels.
InVitro studies shows that androgens, but not estrogens, increase adrenergic alpha 2 expression in non specific tissue thus inhibiting lipolysis. On the other hand, androgens showed inhibition of adipocyte proliferation i.e. formation of new fatty cells whilst estrogen increases.
Estrogens on the other hand resulted in increased adenylyl cyclase activity suggesting enhanced beta adrenoceptor activity and so increased downstream lipolytic activity.
Based on the information provided above, i conclude healthy levels of estrogens is optimal for fat loss. Real life results may be completely different but most theories are based on vitro evidence, so using AAs may be counter productive.
But then again, considering that plenty of fat burners contain a2 inhibitors in some form and that increased AR activity is muscle sparing, slight decreases(if any) is a low price to pay for holding on to hard earned muscle.
03-11-2013, 07:33 AM
Was taking Alphamine for 20 days and little change in my belly area even with light weight lifting 3x a week and almost no change in weight.
Then 3 weeks break and I've started taking Erase Pro 3x/week 1 cap and in next 3 weeks without any exercise I've lost 1kg and even saw slightly 6 pack in belly area.
Not to mention overall improvement in quality of sleep, mood - was very impressed not to mention convenience of taking 1 cap just 2 or 3x a week.
Tried before also Erase at 3 caps a day for 6 days and all 6 days no morning wood but no such problem when taking Erase Pro.
Which tells me everybody needs to find their sweet spot not to crush estrogen too low and wood is best indicator to tell you this.
03-11-2013, 07:59 AM
03-11-2013, 11:32 AM
03-11-2013, 11:59 AM
03-11-2013, 02:52 PM
03-11-2013, 10:20 PM
03-12-2013, 02:11 AM
03-12-2013, 02:21 AM
The data is definitely muddled, and obviously one cannot compare Erase to an estrogen knockout mouse. Plus, as you said, forskolin and/or rauwolscine would ameliorate any adrenergic effects that may arise, though I don't foresee such from a 4-8 week Erase cycle.
To the others: Rebound is no concern, practically speaking
03-12-2013, 03:35 AM
Now that I'm around 12-13 % even one dose of OG Erase dries out my joints...shame because I really enjoyed its 'drying out' effects.
03-12-2013, 11:34 AM
03-12-2013, 11:40 AM
03-12-2013, 12:01 PM
03-12-2013, 12:13 PM
03-12-2013, 02:43 PM
03-12-2013, 03:58 PM
03-12-2013, 10:33 PM
03-12-2013, 11:16 PM
03-13-2013, 12:27 AM
03-13-2013, 01:52 AM
03-13-2013, 02:31 AM
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