Clinical trials to date are not large enough or long enough to determine the potential effects of testosterone treatment on prostate cancer. Existing data does not indicate that testosterone promotes prostate cancer. Hajjar et al (1997)#1 treated elderly men with a replacement dose of testosterone and found no increase in prostate cancer during a 2-year follow-up. Agarwal and Oefelein (2005)#2 administered testosterone for 19 months to hypogonadal patients with a history of prostate cancer and prostatectomy, but whose recent PSA levels were low. Treatment significantly elevated circulating testosterone and improved quality of life without elevating PSA.
#1
http://www.ncbi.nlm.nih.gov/m/pubmed/9360543/
#2
http://www.ncbi.nlm.nih.gov/m/pubmed/15643240/
So far, there is no compelling evidence that testosterone has a causative role in prostate cancer.271,272,278,279
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701485/
One new study found that HPV alone is present in about 70% of the malignant prostate cancers sampled. Can't source the study but I remember reading it. I know certain strains of HPV are estrogen dependent... so from my extreme lack of knowledge I guess I can try to say I think HPV related prostate cancers come when certain men get older, testosterone drops and estrogen starts to play a bigger role. Shot in the dark but what do I know.
I'm on my phone tired of sourcing so read this. If anything read the title.
http://www.medscape.com/viewarticle/742985_5