Agmatine, muscle builder or prostate breaker?
- 02-25-2013, 11:05 AM
Agmatine, muscle builder or prostate breaker?
Since few years companies are promoting Agmatine. And based on the user feedback it seems that it's working well for pump, vascularity and hypertrophy. But how safe is it in regard to prostate health? It seems that Agmatine increases synthesis of arachidonic acid in the body. Now It has been shown that arachidonic acid stimulates the growth of prostate cancer cells. Studies show that incidences of prostate cancer is greatest in regions with high consumption of foods rich in arachidonic acid. This leads to my question: is agmatine safe for men? And what impact does it have on our prostate?
- 02-25-2013, 11:09 AM
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02-25-2013, 11:19 AM
Actually it's one of his posts that reminded me of this possible relation between agmatine and prostate cancer.
02-25-2013, 01:19 PM
02-25-2013, 01:53 PM
This meta-analysis seems to say differently
The available epidemiologic evidence is weak because of the limited number of studies and their methodological limitations, but nonetheless, the results suggest that ARA exposure is not associated with increased breast and prostate cancer risk. Further evidence from well-designed observational studies is required to confirm or refute the association between ARA exposure and risk of cancer.
02-25-2013, 02:37 PM
Evolving data suggest a significant role for some areas of the arachidonic acid pathway in prostate cancer. Inhibiting 1 or a number of these enzymes in combination may hold promise for future prostate cancer treatment
Myers major activities revolved around prostate cancer treatment and research. His laboratory research was focused on why a diet high in animal fat appears to foster progression in prostate cancer. His research group demonstrated that a fatty acid, arachidonic acid, common in meat, dairy products, and egg yolks promotes the survival and growth of human prostate cancer cells. They showed that arachidonic acid is converted to a hormone, 5-HETE, which appears to foster the spread of prostate cancer.
02-25-2013, 02:42 PM
Just as an experienced supplement user:If you're > 35 years old....pass on it...nothing is worth cancer..nothing. If you use it, keep your dosing reasonable. MrBEEF
02-25-2013, 03:52 PM
02-25-2013, 04:34 PM
02-25-2013, 04:51 PM
02-25-2013, 04:57 PM
02-25-2013, 05:43 PM
To assess the inhibitory effect of agmatine on tumor growth in vivo and tumor cell proliferation in vitro.
Agmatine had significant inhibitory effect on transplanted tumor growth in vivo and proliferation of tumor cells in vitro, and the mechanism might be a result of inducing decrease of intracellular polyamine contents.
02-25-2013, 05:53 PM
This thread is making huge leaps and is only going to lead to fear backed up with no data, just like the whole DAA thing. 1) Agmatine supplementation is not Arachidonic Acid supplementation. Yes there is a connection, but not the same thing and you cannot just cite AA studies to say that agmatine is dangerous. 2) None of these studies is saying that AA supplementation is going to increase your risk of prostate cancer. The pathway has more than one branch.
02-25-2013, 05:54 PM
02-25-2013, 06:32 PM
02-25-2013, 06:35 PM
Arachidonic acid is not causative of cancer. If you have cancer (or a genetic mutation that predisposes you [2-hit hypothesis]), then ArA supplementation may not be the best idea.
02-25-2013, 06:36 PM
02-25-2013, 06:38 PM
02-25-2013, 08:25 PM
02-26-2013, 02:15 AM
02-26-2013, 02:21 AM
02-26-2013, 03:17 AM
02-26-2013, 03:21 AM
02-26-2013, 03:23 AM
90% of autopsies in men who died of natural causes reveal that the individual had prostate cancer (not the cause of death).
ArA is an EFA used for a ton of signaling pathways, and many individuals who supplement fish oil can disrupt the ratio of epa/dha to ara over time. The key has always been balance, and a brief run of ArA will transiently increase the ArA ratio before returning back to a "balanced" state thereafer.
Agmatine is a completely different story and it would be illogical to extrapolate prostate cancer data to agmatine. To put the scale in perspective, it's like saying sunlight causes skin cancer, therefore going for a walk will cause skin cancer.
Btw, you persian? I noticed the rostam username
02-26-2013, 04:48 AM
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