Agmatine, muscle builder or prostate breaker?

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    Moretti RM, Montagnani MM, Sala A, Motta M, Limonta P. Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase. Int J Cancer. 2004 Oct 20;112(1):87-93.

    Hassan S, Carraway RE. Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth. Regul Pept. 2006 Jan 15;133(1-3):105-14.

    Ghosh J, Myers CE. Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun. 1997 Jun 18;235(2):418-23.

    Ghosh J. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem Biophys Res Commun. 2003 Jul 25;307(2):342-9.

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    Quote Originally Posted by Rostam View Post
    Do you need a study to show you the mechanism of action of agmatine?
    In the way that you seem to think it works by significantly increasing ARA, yes I do.
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    Quote Originally Posted by Rostam View Post
    You know that most prostate Cancer remain dormant for many years. And you are saying to stay away from ARA in case of cancer. Therefore potentially every body should stay away from ARA or agmatine since nobody knows for sure if there are some cancerous cell in their body or if they are genetically prone to cancer. This is not a suggestion but just a thought
    by the same logic, everyone should avoid carbohydrates as carbohydrates as fuel are a major part of tumor growth as well, and tumors grow far slower in a low carb environment
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    Quote Originally Posted by Rostam View Post
    Moretti RM, Montagnani MM, Sala A, Motta M, Limonta P. Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase. Int J Cancer. 2004 Oct 20;112(1):87-93.

    Hassan S, Carraway RE. Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth. Regul Pept. 2006 Jan 15;133(1-3):105-14.

    Ghosh J, Myers CE. Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun. 1997 Jun 18;235(2):418-23.

    Ghosh J. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem Biophys Res Commun. 2003 Jul 25;307(2):342-9.
    And you have read these? Thank you for posting studies on 5-lipoxygenase and its possible role in prostate cancer. Now, maybe answer what I actually asked?
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    Quote Originally Posted by EasyEJL View Post
    by the same logic, everyone should avoid carbohydrates as carbohydrates as fuel are a major part of tumor growth as well, and tumors grow far slower in a low carb environment
    Breathing too! :P
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    Actually carbohydrates do fuel tumor grouth. But ingesting or not carbohydrate is a personal choice. Same for ARA or agmatine
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    Quote Originally Posted by Aleksandar37 View Post

    Breathing too! :P
    Lol NOxide also increases tumor growth . So guess we should breathe huh
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    This thread is ironic. On a forum that most are okay with hitting peptides up like candy (IGF).
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    Quote Originally Posted by mr.cooper69 View Post
    90% of autopsies in men who died of natural causes reveal that the individual had prostate cancer (not the cause of death).

    This statement seemed so outlandish that I googled it....I found some .com and .org soruces that seem to back up the info. Shocking fact imo.

    "Autopsies in 70-year-old patients show that 46% of males have prostate cancer, but fortunately, it is very slow growing compared to other cancers. About 90% of prostate cancers remain latent over decades. Microscopic foci of adenocarcinoma can be found in 85-90% of men over 80 years of age, which confirms that most men with prostate cancer die from causes unrelated to the malignant tumour."

    So while I'm not even close to being convinced that agmatine has anything to do with prostate cancer, you can learn something new in every thread.
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    Quote Originally Posted by Rostam View Post

    People are free to beleave what ever they want. If you 100% confident with whatever product you take then this is fine. For my part I prefer to raise questions even if it does not plese most of people. I'm not claiming anything I just presented some facts. this is a fact that Agmatine increases the sysnthesis of ARA. and based on various studies it seems that ARA contribute to prostate cancer or at least to it's progression. I did not force anybody to stop using agmatine or any other product.
    And by that logic lifting weights increases Testosterone, which is implicated in prostate cancer. So you don't lift weights because you're scared of cancer?

    Or I'll take it a step further in your logic - lifting weights increases Testosterone, which increases the substrate for estrogen in the male body, which is also implicated in cancer.

    Brb, canceling gym membership cause of cancer.
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    Quote Originally Posted by Lutztenways View Post
    This statement seemed so outlandish that I googled it....I found some .com and .org soruces that seem to back up the info. Shocking fact imo.

    "Autopsies in 70-year-old patients show that 46% of males have prostate cancer, but fortunately, it is very slow growing compared to other cancers. About 90% of prostate cancers remain latent over decades. Microscopic foci of adenocarcinoma can be found in 85-90% of men over 80 years of age, which confirms that most men with prostate cancer die from causes unrelated to the malignant tumour."

    So while I'm not even close to being convinced that agmatine has anything to do with prostate cancer, you can learn something new in every thread.
    Crazy right?


    Anyway, I can't stress enough that this extrapolation of agmatine is nonsensical! Arachidonic acid is an intermediate in agmatine imidazoline signaling....SO WHAT? Arachidonic acid is an intermediate in a million signaling processes. What about all the other net effects of agmatine?

    In fact, all the data I see on agmatine shows ANTI-cancer effects. This is because, like any compound, agmatine has mixed roles in the body. And the net effect of these various roles leads to the prevention, not production, of carcinoma.
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    I remember as a kid someone making the statement that "if you live long enough you'll die from cancer."

    As stated there are millions of 70, 80 and 90 year olds who are now corpses in the ground. If you did autopsies on them you would discover a variety or early to later stage cancers. They just happened to die from something else before the cancer could get them.
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    Quote Originally Posted by David Dunn View Post
    I remember as a kid someone making the statement that "if you live long enough you'll die from cancer."

    As stated there are millions of 70, 80 and 90 year olds who are now corpses in the ground. If you did autopsies on them you would discover a variety or early to later stage cancers. They just happened to die from something else before the cancer could get them.
    .....something caught while in the hospital sick from cancer or something else when immunity is weak which ends up killing faster
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    Thank you cooper for your constructive posts. Much appreciated.

    How do you know Rostam is Persian? : )
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    Cool


    Quote Originally Posted by Rostam View Post
    Thank you cooper for your constructive posts. Much appreciated.

    How do you know Rostam is Persian? : )
    I'm persian
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    These kinds of substances always put the prostate at risk and that's why taking a good prostate supplement becomes even more important. If you're looking for the best, read Super Beta Prostate reviews. This supplement not only contains large amounts of plant sterols but also other minerals and it is all natural. There are no side-effects.
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