Agmatine, muscle builder or prostate breaker?

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  1. Quote Originally Posted by Rostam View Post
    Since few years companies are promoting Agmatine. And based on the user feedback it seems that it's working well for pump, vascularity and hypertrophy. But how safe is it in regard to prostate health? It seems that Agmatine increases synthesis of arachidonic acid in the body. Now It has been shown that arachidonic acid stimulates the growth of prostate cancer cells. Studies show that incidences of prostate cancer is greatest in regions with high consumption of foods rich in arachidonic acid. This leads to my question: is agmatine safe for men? And what impact does it have on our prostate?
    Umm...those
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  2. Watching this thread due to my age of 52 and my use of agmatine. Here is a link to what I think is the research:

    http://www.ncbi.nlm.nih.gov/m/pubmed/18343442/
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  3. Interesting that this research shows that agmatine can have anti- proliferation effects:

    http://m.molpharm.aspetjournals.org/.../71/1/276.full
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  4. Quote Originally Posted by Aleksandar37 View Post

    Umm...those
    These are not claims but facts. Agmatine increase the synthesis of ARA, this is not a claim but a fact. And studies have linked ARA to possible increased rate of cancer, again this not a claim. there are plenty of study about that. You can have a look at Pubmed.

  5. Quote Originally Posted by Ballesteri View Post
    http://www.ncbi.nlm.nih.gov/pubmed/18343442

    CONCLUSIONS:


    Evolving data suggest a significant role for some areas of the arachidonic acid pathway in prostate cancer. Inhibiting 1 or a number of these enzymes in combination may hold promise for future prostate cancer treatment.

    http://www.prostateforum.com/about-dr-myers.html

    Myers major activities revolved around prostate cancer treatment and research. His laboratory research was focused on why a diet high in animal fat appears to foster progression in prostate cancer. His research group demonstrated that a fatty acid, arachidonic acid, common in meat, dairy products, and egg yolks promotes the survival and growth of human prostate cancer cells. They showed that arachidonic acid is converted to a hormone, 5-HETE, which appears to foster the spread of prostate cancer.
    Quote Originally Posted by kenpoengineer View Post
    Watching this thread due to my age of 52 and my use of agmatine. Here is a link to what I think is the research:

    http://www.ncbi.nlm.nih.gov/m/pubmed/18343442/
    ...
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  6. Quote Originally Posted by Rostam View Post
    These are not claims but facts. Agmatine increase the synthesis of ARA, this is not a claim but a fact. And studies have linked ARA to possible increased rate of cancer, again this not a claim. there are plenty of study about that. You can have a look at Pubmed.
    And I will continue to call this complete bull**** and say that you are using scare tactics based on not a single shread of evidence until you post studies to back up your claims. And please post papers that you have actually read, not random abstracts from pubmed. This board is meant to educate, not to make wild claims backed up by no data which will only serve to confuse and cause fear when there is none.
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  7. Quote Originally Posted by Rostam View Post

    These are not claims but facts. Agmatine increase the synthesis of ARA, this is not a claim but a fact. And studies have linked ARA to possible increased rate of cancer, again this not a claim. there are plenty of study about that. You can have a look at Pubmed.
    Agmatine isn't going to give you cancer. I don't want to be the meat head that goes "durp, take this it's completely safe!"...except that is the case here.

    To me, what you're saying is - "don't work out, because working out raises Testosterone, and that causes prostate cancer"
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  8. Quote Originally Posted by Aleksandar37 View Post
    And I will continue to call this complete bull**** and say that you are using scare tactics based on not a single shread of evidence until you post studies to back up your claims. And please post papers that you have actually read, not random abstracts from pubmed. This board is meant to educate, not to make wild claims backed up by no data which will only serve to confuse and cause fear when there is none.
    Then don't waist your time in this Thread.

  9. Quote Originally Posted by Rostam View Post
    Then don't waist your time in this Thread.
    I'm a fan of keeping the board full of facts and actually backing up claims with research, so I will be staying thanks!!!
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  10. Quote Originally Posted by kevinhy View Post
    Agmatine isn't going to give you cancer. I don't want to be the meat head that goes "durp, take this it's completely safe!"...except that is the case here.

    To me, what you're saying is - "don't work out, because working out raises Testosterone, and that causes prostate cancer"
    People are free to beleave what ever they want. If you 100% confident with whatever product you take then this is fine. For my part I prefer to raise questions even if it does not plese most of people. I'm not claiming anything I just presented some facts. this is a fact that Agmatine increases the sysnthesis of ARA. and based on various studies it seems that ARA contribute to prostate cancer or at least to it's progression. I did not force anybody to stop using agmatine or any other product.

  11. In for a real study and real answers. Ill hop on for some research in a bit.

  12. Quote Originally Posted by Rostam View Post
    People are free to beleave what ever they want. If you 100% confident with whatever product you take then this is fine. For my part I prefer to raise questions even if it does not plese most of people. I'm not claiming anything I just presented some facts. this is a fact that Agmatine increases the sysnthesis of ARA. and based on various studies it seems that ARA contribute to prostate cancer or at least to it's progression. I did not force anybody to stop using agmatine or any other product.
    For the last time, your opinions are not facts! You have yet to cite a single source and we can not have a productive debate unless you do. Saying they are facts over and over again does not make it true!
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  13. What is not a fact? the mechanisme of action of Agmatine?

  14. Quote Originally Posted by Rostam View Post
    Since few years companies are promoting Agmatine. And based on the user feedback it seems that it's working well for pump, vascularity and hypertrophy. But how safe is it in regard to prostate health? It seems that Agmatine increases synthesis of arachidonic acid in the body. Now It has been shown that arachidonic acid stimulates the growth of prostate cancer cells. Studies show that incidences of prostate cancer is greatest in regions with high consumption of foods rich in arachidonic acid. This leads to my question: is agmatine safe for men? And what impact does it have on our prostate?
    I highlighted your 3 original claims (again). Do you have studies or even a webpage or even a wikipedia page or even anything to back these claims up? This should not be that hard to understand.
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  15. Do you need a study to show you the mechanism of action of agmatine?

  16. Moretti RM, Montagnani MM, Sala A, Motta M, Limonta P. Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase. Int J Cancer. 2004 Oct 20;112(1):87-93.

    Hassan S, Carraway RE. Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth. Regul Pept. 2006 Jan 15;133(1-3):105-14.

    Ghosh J, Myers CE. Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun. 1997 Jun 18;235(2):418-23.

    Ghosh J. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem Biophys Res Commun. 2003 Jul 25;307(2):342-9.

  17. Quote Originally Posted by Rostam View Post
    Do you need a study to show you the mechanism of action of agmatine?
    In the way that you seem to think it works by significantly increasing ARA, yes I do.
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  18. Quote Originally Posted by Rostam View Post
    You know that most prostate Cancer remain dormant for many years. And you are saying to stay away from ARA in case of cancer. Therefore potentially every body should stay away from ARA or agmatine since nobody knows for sure if there are some cancerous cell in their body or if they are genetically prone to cancer. This is not a suggestion but just a thought
    by the same logic, everyone should avoid carbohydrates as carbohydrates as fuel are a major part of tumor growth as well, and tumors grow far slower in a low carb environment

  19. Quote Originally Posted by Rostam View Post
    Moretti RM, Montagnani MM, Sala A, Motta M, Limonta P. Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase. Int J Cancer. 2004 Oct 20;112(1):87-93.

    Hassan S, Carraway RE. Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth. Regul Pept. 2006 Jan 15;133(1-3):105-14.

    Ghosh J, Myers CE. Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun. 1997 Jun 18;235(2):418-23.

    Ghosh J. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem Biophys Res Commun. 2003 Jul 25;307(2):342-9.
    And you have read these? Thank you for posting studies on 5-lipoxygenase and its possible role in prostate cancer. Now, maybe answer what I actually asked?
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  20. Quote Originally Posted by EasyEJL View Post
    by the same logic, everyone should avoid carbohydrates as carbohydrates as fuel are a major part of tumor growth as well, and tumors grow far slower in a low carb environment
    Breathing too! :P
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  21. Actually carbohydrates do fuel tumor grouth. But ingesting or not carbohydrate is a personal choice. Same for ARA or agmatine

  22. Quote Originally Posted by Aleksandar37 View Post

    Breathing too! :P
    Lol NOxide also increases tumor growth . So guess we should breathe huh

  23. This thread is ironic. On a forum that most are okay with hitting peptides up like candy (IGF).
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  24. Quote Originally Posted by mr.cooper69 View Post
    90% of autopsies in men who died of natural causes reveal that the individual had prostate cancer (not the cause of death).

    This statement seemed so outlandish that I googled it....I found some .com and .org soruces that seem to back up the info. Shocking fact imo.

    "Autopsies in 70-year-old patients show that 46% of males have prostate cancer, but fortunately, it is very slow growing compared to other cancers. About 90% of prostate cancers remain latent over decades. Microscopic foci of adenocarcinoma can be found in 85-90% of men over 80 years of age, which confirms that most men with prostate cancer die from causes unrelated to the malignant tumour."

    So while I'm not even close to being convinced that agmatine has anything to do with prostate cancer, you can learn something new in every thread.

  25. Quote Originally Posted by Rostam View Post

    People are free to beleave what ever they want. If you 100% confident with whatever product you take then this is fine. For my part I prefer to raise questions even if it does not plese most of people. I'm not claiming anything I just presented some facts. this is a fact that Agmatine increases the sysnthesis of ARA. and based on various studies it seems that ARA contribute to prostate cancer or at least to it's progression. I did not force anybody to stop using agmatine or any other product.
    And by that logic lifting weights increases Testosterone, which is implicated in prostate cancer. So you don't lift weights because you're scared of cancer?

    Or I'll take it a step further in your logic - lifting weights increases Testosterone, which increases the substrate for estrogen in the male body, which is also implicated in cancer.

    Brb, canceling gym membership cause of cancer.
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