New Stim: Anteus Labs AXON??

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    New Stim: Anteus Labs AXON??


    Will one of you brainiacs break this down please? Thanks

    ---------------------------------------------------------------

    Hederagenin
    ((3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oic acid)

    ...There are
    many stimulants on the market -- but none of them are anything like
    this.

    AXON is based on a triterpene known as "Hederagenin" -- extracted
    from Hedera Helix. This triterpene is a triple monoamine reuptake inhibitor: A
    high-affinity substrate for the dopamine, 5-HT, and norepinephrine neural
    membrane transporters. (DAT, SERT, and NET, respectively.) Before we expound on
    this specific function any further, a few general words on how these monoamine
    neurotransmitters work:

    The human brain contains billions of neurons
    which release neurotransmitters. They all consist of a cell body (the soma)
    & a long chain (the axon) which connects via branches to other neurons.
    Transmission via the axon is how one cell can influence others, and this is
    often carried out via monoamines such as DA, NE, 5HT; in response to electrical
    stimuli, they are released from the axon terminal into the synaptic gap, where
    they seek out and bind to receptors on the other side of the gap, on other
    neurons. This binding is not permanent: most of these monoamines are shaken-off
    their receptors in a matter of milliseconds, and are then 'available' once
    again. Their function is terminated by monoamine reuptake from the synaptic
    cleft back into the neuron via membrane-bound transporter proteins.
    (Glycoproteins, typically.) Following reuptake, most are metabolized into inert
    derivatives, and some are recycled and re-released.

    ...As you can
    imagine, when reuptake proteins are inhibited, monoamine breakdown comes
    grinding to a halt and they start accumulating outside neurons -- eventually
    flooding synapses & increasing transmission to supraphysiological levels.


    That's the whole point. Reuptake-inhibition makes for a powerful
    stimulant. Although Hederagenin has its mechanism of action in common with some
    banned chemicals, no ingredient previously released as a supplement is anything
    quite like it. Ephedrine, for example, is a potent NET inhibitor, but has an
    extremely weak effect on dopaminergic transmission and no effects at all where
    the serotogenic pathway is concerned.

    By increasing dopaminergic,
    adrenergic, and serotogenic transmission, you get an increase in energy levels,
    heightened focus, an elevated mood, increased confidence and drive, and an
    revved-up metabolic rate.

    And there is another interesting and
    potentially-useful effect: α-hederin, a hederagenin saponin present in high
    quantities in Hedera Helix (and therefore AXON), prevents β2-adrenoceptor
    internalization and desensitization. In doing so, it strongly increases the
    binding potential of these receptors to other ligands. It is therefore likely
    that AXON has a synergystic effect with compounds which target and bind to the
    β2-adrenoceptor.

    AXON can be stacked with other non-stimulant fat
    burners. It is completely safe for human consumption, and has been side-effect
    free in all of our testers.
    Use as part of a weight-loss regimen, to increase
    performance and endurance in the gym, or for the long-lasting energy you need to
    cope with a busy work or study schedule.

    Where pharmacokinetics are
    concerned:
    Hederagenin is very lipophilic & nearly-insoluble in water. It
    is slowly and poorly absorbed from the GI tract, but the half-life &
    duration of effect of the absorbed fraction is long. (6-8+hrs.) As has been
    conclusively shown with another triterpene, boswelic acid, absorption and
    bioavailability will increase tremendously when taken with food.
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    First thing one of those nerds will tell you is that it is not a stimulant. I've used it and love it. I can't use it for extended periods though because after a while it seems to cause weird side effects. After taking it continuously for several days I start to just not feel right in the head. I was even walking home from the gym one day after taking 2 caps pre-workout and was seeing shadows. There was a truck parked on the side of the road and I had to do a double take because I thought I saw someone inside, but this was not the case. Just didn't feel right emotionally. A bit depressed. At that point I'd stop for a week. It must build up in your system or something. First few days I felt amazing. Great energy and focus in the gym, don't need a pre-workout either. The stuff definitely works better with a big meal.
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    Quote Originally Posted by T-Bone View Post
    First thing one of those nerds will tell you is that it is not a stimulant. I've used it and love it. I can't use it for extended periods though because after a while it seems to cause weird side effects. After taking it continuously for several days I start to just not feel right in the head. I was even walking home from the gym one day after taking 2 caps pre-workout and was seeing shadows. There was a truck parked on the side of the road and I had to do a double take because I thought I saw someone inside, but this was not the case. Just didn't feel right emotionally. A bit depressed. At that point I'd stop for a week. It must build up in your system or something. First few days I felt amazing. Great energy and focus in the gym, don't need a pre-workout either. The stuff definitely works better with a big meal.
    ^nerd
    EvoMuse
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    Quote Originally Posted by T-Bone View Post
    First thing one of those nerds will tell you is that it is not a stimulant. I've used it and love it. I can't use it for extended periods though because after a while it seems to cause weird side effects. After taking it continuously for several days I start to just not feel right in the head. I was even walking home from the gym one day after taking 2 caps pre-workout and was seeing shadows. There was a truck parked on the side of the road and I had to do a double take because I thought I saw someone inside, but this was not the case. Just didn't feel right emotionally. A bit depressed. At that point I'd stop for a week. It must build up in your system or something. First few days I felt amazing. Great energy and focus in the gym, don't need a pre-workout either. The stuff definitely works better with a big meal.
    Those effects align more closely with 5ht2a agonism then classical "stimulation."

    It's interesting to note that all of the positive research on Hederagenin was performed by the same team of Chinese researchers at the exact same institution (Southern Medical University, Guangzhou, China).

    I wouldn't consider any of their research to be legitimate unless its replicated by someone else, at a different location.
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    I'm reading up on it now. From what I gather here it's a compound that blocks proteins which tell the beta-2 receptors to not metabolize the neurotransmitters it receives but instead allow them to re enter the synapsis. Any amine that acts on the beta2 adrenoreceptor would be allowed to go back out of the cell to act on it again therefore flooding the synapse to create massive stimulation. This is often the goal of products acting in a nuero sense: increase the concentration of a given neurotransmitter amongst neurons to allow immediate increase in stimulation and possibly inhibit any enzymes that breakdown the compound for longer duration. The "flooding" of the receptor also overcompensates for any inhibitors existing outside the cell which may prevent breakdown before ever reaching the receptor.

    The fat solubility is an interesting and important tid bit. Must take with a meal containing fats.

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