Could you link me to a human study about 3,3' -diiodo-l-thyronine serving as a supplement? I've checked pubmed / google.
There are no human studies.
In rats, 3,3'-T2 (3,3'-Diiodo-L-thyronine) and other analogues (including 3,5-T2) were tested for calorigenic activity (measured through oxygen consumption) and compared against L-thyroxine.
3,3'-T2 demonstrated <3% of the calorigenic capacity of L-thyroxine, which was also beyond the detection limit.
Stassili, Kroc and Metlzer, Antigoitrogenic and calorigenic activities of thyroxine analogs in rats, Endocrinology 64, 62-82 (1959).
In 1960, 3,3'-T2 was once again tested on rats with other thyroxine analogues for calorigenic activity by several different assays and utilizing a lower detection limit.
3,3'-T2 was found to have no calorigenic activity.
Tomich, Wollett and Pratt, J. Endocrinol. 20, 65-8 (1960)
In 1955 & 1956, 3,3'-T2 was tested for calorigenic activity in the model of hypothyroidism (via thyroidectomized rats) and was found to be completely inactive. It did show weak goitrogenic activity.
Gemmill, Anderson and Burger (1955). Also Gemmill, Am. J. Physiol. 186, 1-5 (1956)
In 1962, various analogues of thyroxine were tested against overall Basal Metabolic Rate (BMR) and tissue probed oxygen consumption.
3,3'-T2 had no activity.
Pittman and Barker, J.Clin. Invest., 41, 695-701 (1962).
In 1959, various T4 analogues including 3,3'-T2 were tested for their ability to directly suppress the thyroid gland.
3,3'-T2 demonstrated 50% inhibition.
The authors concluded:
As an interesting side observation, when about 50% of the thyroxine activity was suppressed, rats began to show other signs of hypothyroidism, such as sluggishness in response, weight gain, coarsening of hair and accumulation of epicantal exudate.
Constance S. Pittman and S. B. Barker Am J Physiol December 1, 1959 197:1271-1274