I really don't suggest with alcohol. Alcohol-induced neurodegeneration is due to compensatory excitotoxicity during withdrawal, inflammatory cytokine/chemokine release by microglial cells, and inhibition of adult neurogenesis. The former of these causes may actually be exacerbated by , which, like alcohol, is also an NMDA-receptor antagonist. If you wanted to use agmatine for neuroprotection, dose it after alcohol has cleared from your system (i.e. when you wake up at night, or the following morning). In this way, you can prevent an excess influx of Ca 2+ into the neurons housing NMDA-receptors during the period of alcohol withdrawal, in which glutamate peaks and NMDARs may experience increased expression in the membrane (usually in chronic cases).