Mucuna(L-Dopa)question

[Killler]

So if I take mucuna extract,it would be solely for prolactin control?

Without carbidopa,it would not get into my brain chemistry?

 

[kevinhy]

So if I take mucuna extract,it would be solely for prolactin control?

Without carbidopa,it would not get into my brain chemistry?

Mucuna will still assist in testosterone production, GH production, and prolactin reduction. Dopamine also has a big role in sex drive, so you should have a heightened sex drive while on it.

 

[baldwanus]

it sort of depends on what % extract you have......different extracts are used for different reasons. be nice is coop popped in this thread, he knows his **** in regards to mucana

 

[Blergs]

GF's been using GHenerate and seems to like it

 

[lronFist]

People with macroprolactinomas, which results in prolactinemia, respond well to dopaminergic compounds because the tumor size is reduced, thereby restoring the function of the pituitary gland in its entirety - elevating LH/FSH, along with a testosterone-elevating local effect in the testicles from prolactin decrement. People with microprolactinomas (smaller tumor burden) do not respond as well to dopaminergic drugs in elevating testosterone, since there is less of a compressive effect on the ant. pituitary. Testosterone is generally not lower in this patient population. For people without compressive tumors but with prolactinemia (i.e. primary hypothyroidism), dopaminergic drugs have been shown to reduce prolactinemia without elevating LH/FSH/testosterone (it is rarely decreased anyhow).

 

[Killler]

Hmmm alright....

But does mucuna(l-dopa) penetrate into the brain chemistry without carbidopa?

I would like to use mucuna for prolactin control but would not like to mess with my dopamine in any major way because I am very prone to depression,anxiety and also I get pretty easily addicted to dopamine raising agents(i.e. drugs)

 

[baldwanus]

Hmmm alright....

But does mucuna(l-dopa) penetrate into the brain chemistry without carbidopa?

I would like to use mucuna for prolactin control but would not like to mess with my dopamine in any major way because I am very prone to depression,anxiety and also I get pretty easily addicted to dopamine raising agents(i.e. drugs)

check out SNS inhibit-p......has mucana among a few other things for prolactin control

 

[taggs]

Hmmm alright....

But does mucuna(l-dopa) penetrate into the brain chemistry without carbidopa?

I would like to use mucuna for prolactin control but would not like to mess with my dopamine in any major way because I am very prone to depression,anxiety and also I get pretty easily addicted to dopamine raising agents(i.e. drugs)

Killer
This is a question I've also been looking to get a conclusive answer for, but from a natural angle i.e. using EGCG instead of carbidopa.
However from the information I can find there are vastly conflicting views put forward from individual companies and their reps. Obviously both can't be right so drawing my own conclusion based on how a medical patient is treated when being administered prolactin lowering drugs, I'm going to use an EGCG product along side mucuna(l-dopa). It will either help inside the brain, outside the brain or won't work full stop. Can't see it doing any harm other than that to my wallet :lol5:

 

[mr.cooper69]

People with macroprolactinomas, which results in prolactinemia, respond well to dopaminergic compounds because the tumor size is reduced, thereby restoring the function of the pituitary gland in its entirety - elevating LH/FSH, along with a testosterone-elevating local effect in the testicles from prolactin decrement. People with microprolactinomas (smaller tumor burden) do not respond as well to dopaminergic drugs in elevating testosterone, since there is less of a compressive effect on the ant. pituitary. Testosterone is generally not lower in this patient population. For people without compressive tumors but with prolactinemia (i.e. primary hypothyroidism), dopaminergic drugs have been shown to reduce prolactinemia without elevating LH/FSH/testosterone (it is rarely decreased anyhow).

The effect on LH/T can theoretically be triggered in a non-adenoma-dependent fashion:

(1): "it is suggested that dopamine may inhibit the release of PRL from the anterior lobe of the pituitary gland, and this stimulates the hypothalamus and forebrain to secrete GnRH, which in turn may activate the anterior pituitary gland to secrete FSH and LH, causing increased synthesis of T by Leydig cells of the testis in infertile subjects (28). Moreover, LH controls steroid production by binding with the receptors on the Leydig cells, thereby inducing the synthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate, and increased levels of cAMP are largely responsible for the upregulation of steroidogenesis 15, 29, 30 and 31."

(1) http://www.sciencedirect.com/science/article/pii/S0015028208039356

There is nothing in the above study to indicate that the patients had prolactinomas.

 

[chedapalooza]

Is there any issue combining different % extracts of mucuna.. For example 20% and 98 percent?

 

[mr.cooper69]

Is there any issue combining different % extracts of mucuna.. For example 20% and 98 percent?

Nope

 

[ahh123]

Nope

What about safe or recommended daily dose of Mucuna extract giving what dose of L-DOPA?

I see Dopadex recommended daily dose is 750mg of L-DOPA coming from 98% extract of Mucuna (while few other supplements recommend up to 500mg).

And how long it should be taken daily and then how long off period?

 

[jcc80]

Hmmm alright....

But does mucuna(l-dopa) penetrate into the brain chemistry without carbidopa?

I would like to use mucuna for prolactin control but would not like to mess with my dopamine in any major way because I am very prone to depression,anxiety and also I get pretty easily addicted to dopamine raising agents(i.e. drugs)

I wouldn't worry about it. I'm the same way, and mucuna doesn't have any recreational value at all. Nothing addictive about it.

 

[saggy321]

The effect on LH/T can theoretically be triggered in a non-adenoma-dependent fashion:

(1): "it is suggested that dopamine may inhibit the release of PRL from the anterior lobe of the pituitary gland, and this stimulates the hypothalamus and forebrain to secrete GnRH, which in turn may activate the anterior pituitary gland to secrete FSH and LH, causing increased synthesis of T by Leydig cells of the testis in infertile subjects (28). Moreover, LH controls steroid production by binding with the receptors on the Leydig cells, thereby inducing the synthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate, and increased levels of cAMP are largely responsible for the upregulation of steroidogenesis 15, 29, 30 and 31."

(1) http://www.sciencedirect.com/science/article/pii/S0015028208039356

There is nothing in the above study to indicate that the patients had prolactinomas.

So combining it with Forskolin would be a good idea to further increase steroidogenesis through?

 

[mr.cooper69]

Indeed

 

[mr.cooper69]

What about safe or recommended daily dose of Mucuna extract giving what dose of L-DOPA?

I see Dopadex recommended daily dose is 750mg of L-DOPA coming from 98% extract of Mucuna (while few other supplements recommend up to 500mg).

And how long it should be taken daily and then how long off period?

These are all loaded questions. It depends on the individual, other supplements, purpose of use, etc. But yes, cycling is a must

 

[Beau]

These are all loaded questions. It depends on the individual, other supplements, purpose of use, etc. But yes, cycling is a must

Do you have any thoughts on various types of cycling (1 month on, 1 month off vs 5 days on, 2 day off vs every other day, etc.).

Do you believe there are advantages on one over the others?

 

[mr.cooper69]

Do you have any thoughts on various types of cycling (1 month on, 1 month off vs 5 days on, 2 day off vs every other day, etc.).

Do you believe there are advantages on one over the others?

Really depends on the above factors again.

 

[ahh123]

Really depends on the above factors again.

Then let's go with specific stack of Endosurge Turbo and Erase Pro mainly for improved libido, mood & testosterone/estrogen/cortisol ratio.

Is it OK taking it for these purpose at 6 caps daily of Endosurge Turbo and Erase Pro at 1 cap 2x or 3x/week for 8 weeks then 4 weeks off?

 

[chedapalooza]

Then let's go with specific stack of Endosurge Turbo and Erase Pro mainly for improved libido, mood & testosterone/estrogen/cortisol ratio.

Is it OK taking it for these purpose at 6 caps daily of Endosurge Turbo and Erase Pro at 1 cap 2x or 3x/week for 8 weeks then 4 weeks off?

I know that would be ok.

I know most sources on here recommend 12 weeks max... Perhaps weeks 9-12 one would switch to a 5 on/2 off schedule. And then at least 4 weeks off.