From what aspect is the glutamine more beneficial? Why not just take bulk leucine? I've never seen anything but 2:1:1 studied that I can recall. What's the benefit?
Not hating. Just saying.
In terms of the leucine, the reasoning here is that, from a strictly technical standpoint, the data displays that only leucine and those other amino acids structurally related to leucine are responsible for the increase in mTOR commonly associated with BCAA supplementation.
By increasing the “normal” ratio of leucine to the other two branched chain amino acids, we ensure two things:
Double & mega dosing are unnecessary, as we have already doubled the component that is primarily responsible for the protein turnover and synthesis increases we see with BCAAs.
Competitive metabolism between the amino acids will not lower leucine levels to the point that it is unable to regulate mTOR.
Simply put, a 2:1:1 or 4:1:1 bias, while effective, is by no means optimal for mTOR signaling pathway activation, and an increase in protein synthesis associated with it.
This particular product consists of a glutamine dipeptide (L-alanyl-L-glutamine), which is more stable and far more water soluble than regular L-glutamine.
These physicochemical properties alone may provide greater effectiveness as compared to l-glutamine. However, the presence of a unique intestinal transporter for the dipeptide may also allow for an increased amount of glutamine to reach the bloodstream and into skeletal muscle as compared to regular free L-glutamine.
These notions are supported by the higher glutamine concentrations in plasma and skeletal muscle of animal models administered alanyl-glutamine, as compared to those observed with free L-glutamine .
Hope that helps my friend.