*Warning* D-Serine --> ALS???

[qwick]

Just asked the university to pick me up this article: d-Amino acid oxidase controls motoneuron degeneration through d-serine

Seems like D-Serine is seen elevated in ALS patients. Might not want to take D-Serine powder....

[mr.cooper69]

All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.

[qwick]

All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.

That's what I took from the abstract as well. But I want to know what the full article has to say. I can post it when I get it if you would like.

[Bamski]

Do it for the general public, im always interested in learning new stuff

[qwick]

Will do. I will try and get it up by the end of the week =)

[franj]

nice

[Bamski]

Thanks man, abstract gives only so much.

[Aleksandar37]

"Our data highlight the pathologic relevance of D-serine increase
derived from reduced DAO activity in ALS. Using inbred mice
lacking DAO activity, we provide evidence that loss of DAO
activity triggers motoneuron degeneration. Moreover, using
biochemical assays and sensitive quantitative methods to detect
DAO activity and D-amino acids in the tissues, we have shown
that (i) DAO activity is drastically suppressed in reactive astrocytes
of the reticulospinal tract of mSOD1 mice, (ii) decreased
degradation due to DAO inactivation contributes dominantly to
the increase of D-serine, and (iii) the reduction of DAO activity
is caused by progressive repression of DAO gene expression that
mediates the NMDAR/ERK pathway."

"In conclusion, this study provides a unique understanding of
the role of DAO and D-serine in motoneuron physiology as well
as in ALS pathophysiology as a putative enhancer of motoneuron
excitability. Our data also stress the potential use of regulators
of DAO activity or D-serine antagonists as a therapeutic
strategy in ALS."

They are saying that D-serine levels may be elevated in individuals with ALS as a result of reduced DAO activity. They are in no way saying that taking D-serine is going to cause ALS in a normal individual.

[qwick]

Correct, but could an abundance of D-Serine reduce DAO activity?

Courtesy of PHF (henryv): http://www65.zippyshare.com/v/25574568/file.html

[henryv]

All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.

^ This.

They are saying that D-serine levels may be elevated in individuals with ALS as a result of reduced DAO activity. They are in no way saying that taking D-serine is going to cause ALS in a normal individual.

^ This.

Courtesy of PHF: http://www65.zippyshare.com/v/25574568/file.html

Courtesy of henryv you mean.

[Aleksandar37]

Correct, but could an abundance of D-Serine reduce DAO activity?

Courtesy of PHF: http://www65.zippyshare.com/v/25574568/file.html

DAO is going to keep doing its job until it runs out of substrate or cofactors needed for activity. An abundance of D-serine would increase overall activity. Also, please consider that this is one article and it is in PNAS, a journal with a peer review process that I don't agree with at all. Members of the NAS get a free pass.

[qwick]

^ This.



^ This.



Courtesy of henryv you mean.

Thank you for clarifying.

DAO is going to keep doing its job until it runs out of substrate or cofactors needed for activity. An abundance of D-serine would increase overall activity. Also, please consider that this is one article and it is in PNAS, a journal with a peer review process that I don't agree with at all. Members of the NAS get a free pass.

I am trying to read as many serine articles that i can get my hands on. Research on d serine is relatively new, so I am trying to soak up as much information as possible. If you know of any articles that range from 2010-2012 that are about serine please let me know. My universities database is weak and I have to wait for certain articles to get mailed to me =/

[Aleksandar37]

Thank you for clarifying.



I am trying to read as many serine articles that i can get my hands on. Research on d serine is relatively new, so I am trying to soak up as much information as possible. If you know of any articles that range from 2010-2012 that are about serine please let me know. My universities database is weak and I have to wait for certain articles to get mailed to me =/

It's not really my field, except I believe they have found overactive DOA in schizophrenia. If you make a list and sent it to me with your email in a PM, I can try and find pdfs for you.

[qwick]

It's not really my field, except I believe they have found overactive DOA in schizophrenia. If you make a list and sent it to me with your email in a PM, I can try and find pdfs for you.

Thanks for the help, but I don't wanna bother you if you have to google dork it =) I can get most article instantly, but some of them I have to wait 2 or 3 days for. But if you could find http://www.ingentaconnect.com/conten...00000007/005aj let me know and Ill pm you my email. Thanks.

[Aleksandar37]

Nope, sorry. I used to have access to Northwestern's database, but the person changed their password finally after 6 years. Those ****ers have everything!

[Patrick Arnold]

Just asked the university to pick me up this article: d-Amino acid oxidase controls motoneuron degeneration through d-serine

Seems like D-Serine is seen elevated in ALS patients. Might not want to take D-Serine powder....

creatinine is elevated in kidney disease. taking creatine (which all converts to creatinine) therefore gives you kidney disease.

[JosNYC]

creatinine is elevated in kidney disease. taking creatine (which all converts to creatinine) therefore gives you kidney disease.

What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.

[Patrick Arnold]

What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.

first of all i was joking.

second of all i am not a doctor so i dunno what low creatinine means.

try google?

[JosNYC]

Didn't pick up on the joking thing...Doc's no help and all that comes up on google are mostly wiki links that have limited info

Thought i'd try and see if you had an article or a data base link that discusses the impact of creatinine levels.

[Aleksandar37]

What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.

Low levels just mean that your kidneys are working great and you are urinating the waste out of your body. It is only a single measure to help point your physician in the direction of a problem. They were not concerned based on how everything else looked.