Intimidate or DAA
- 07-24-2012, 10:36 AM
- 07-24-2012, 10:37 AM
And I have, In fact, I can send you a picture of the bottle with my username and the 4 caps left in it.
Vaughn, bowing out would be the right thing to do. As the conversation would end when Coop answers my last question. Otherwise I have a few things to post in regards to NMDA.
- 07-24-2012, 10:38 AM
07-24-2012, 10:41 AM
If you know all this and think its true...Why don't you simply keep it as your opinion and don't take it for yourself again? Rather than starting a p1ssing contest with a Rep without any point or meaning whatsoever?
Don't like it? don't take it !
>SNS-Glycophase<Serious Nutrition Solutions Rep
07-24-2012, 10:46 AM
Vaughn, if you would prefer to take this to PM or Email, Id be happy to do that as well.
Edit- But you're right, I shouldnt have jumped like that and I apologize.
07-24-2012, 11:11 AM
Yeh. I did a search there r a few ppl that had the same prob. I must have gotten used to it now thoughOriginally Posted by Celorza
GAME ON! MOVAH FUKAZ!
07-24-2012, 12:30 PM
UNLEASH ALL OUT WAR ON YOUR HPTA
THE DRIVING FORCE OF INTIMIDATE!N-Methyl-D-Aspartic Acid (NMDA) is an amino acid derivative capable of causing an intensely anabolic response from NMDA receptors found within our bodies. NMDA receptors are designed to accept only certain compounds to connect to them, the most potent being NMDA. When NMDA binds to an NMDA receptor our HPTA (hypothalamic-pituitary-gonadal axis) is sent into overdrive.INTIMIDATE IS THE ONLY PRODUCT WITH 99.9% PURE NMDA!
Sleep is the one time of day that our body can recover, repair, and grow. By getting more restful sleep, your body will be able to repair and grow your muscles more efficiently than before.
One of the quickest signs that your body is in an anabolic state and ready for major fat loss and muscle gain!
Activating NMDA receptors may help increase “feel good” chemicals in our bodies. Compounds such as Pregnenolone help us feel great throughout the day. Pregnenolone greatly increases in the presence of intense NMDA receptor activation.Long Term Memory:
We each have both short term and long term memory we pull from. Short term memory is for things like remembering that cute girls name you met 20 minutes ago. Your brain allows you to store memories for a short time period, and then it discards them unless you activate certain receptors to initiate long term storage. These receptors just so happen to be NMDA receptors. When we activate our NMDA receptors, our brains are primed to convert short term memory into long term memory, which means things should be easier to remember, and easier to recall when needed!
When it comes to the discovery of dietary supplements, iForce Nutrition has always pushed the boundaries and created the most unique and effective ingredients ever released. INTIMIDATE will push your body’s natural limits to new heights as you get bigger, stronger, faster, and leaner all at the same time. Don’t fall for the DAA hype, and use only the most pure and effective NMDA receptor activator on the planet…INTIMIDATE!**These statements have not been approved by the FDA.[/quote
Please, show me evidence that suggests oral ingested NMDA will harm someone. Patrick Arnold agrees that it will not, as does every single person who has actually researched the ingredient.
"Bow out"? LOL you're kidding me right? Jeeze...I didn't realize I couldn't disagree with an Axis Labs rep...man you guys are just too cool, looks like I should delete my account and start buying more axis labs products!
07-24-2012, 12:32 PM
Just in case you're a little nervous about using NMDA, take a look at what reverses direct nmda induced neurotoxicity(induced from direct brain application mind you...NOT oral...LOL
Neuroprotective effects of creatine administration against NMDA and malonate toxicity.
Malcon C, Kaddurah-Daouk R, Beal MF.
Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
We examined whether creatine administration could exert neuroprotective effects against excitotoxicity mediated by N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainic acid. Oral administration of 1% creatine significantly attenuated striatal excitotoxic lesions produced by NMDA, but had no effect on lesions produced by AMPA or kainic acid. Both creatine and nicotinamide can exert significant protective effects against malonate-induced striatal lesions. We, therefore, examined whether nicotinamide could exert additive neuroprotective effects with creatine against malonate-induced lesions. Nicotinamide with creatine produced significantly better neuroprotection than creatine alone against malonate-induced lesions. Creatine can, therefore, produce significant neuroprotective effects against NMDA mediated excitotoxic lesions in vivo and the combination of nicotinamide with creatine exerts additive neuroprotective effects.
07-24-2012, 12:34 PM
and the ULTIMATE reference...wikipedia:
NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in 1960s. NMDA is an excitotoxin (it kills nerve cells by over-exciting them); this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies." Researchers apply NMDA to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior.
However, in lower quantities NMDA is not neurotoxic. In fact, normal operation of the NMDA receptor allows individuals to respond to excitatory stimuli through the interrelated functioning of NMDA receptors, glutamate, and dopamine.
Therefore the action of glutamate specifically through NMDA receptors can be investigated by injecting small quantities of NMDA into a certain region in the brain: for example, injection of NMDA in a brainstem region induces involuntary locomotion in cats and rats.
07-24-2012, 12:37 PM
And heres an old favorite from "neuron" on bb.com...
Originally Posted by madchemist
the NMDA receptor is a voltage-gated channel which requires previous activation of the AMPA receptor for membrane depolarization
since the compound "NMDA" cannot agonize the AMPA receptor, its ability to activate the NMDA receptor would be limited, and so a direct neurotoxic effect will not likely occur from oral supplementation
if you take a neuron in a vacuum (en vitro), its normal electrical homeostasis is disrupted, and the NMDA receptor no longer is voltage gated. if you bath this neuron in NMDA, excitotoxicity will occur, whereas en vivo it can't
07-24-2012, 12:40 PM
07-24-2012, 12:41 PM
07-24-2012, 01:01 PM
This remains unanswered, in regards to the study you post.Unless you have documentation on their methodology showing that they directly injected the NMDA, this abstract is making a case against your argument, if anything.
07-24-2012, 01:04 PM
07-24-2012, 05:35 PM
Ok, just got back. The bottom line is that we don't know what dose of oral NMDA can cause excitoxicity. Oral doses are far safer than injections into the brain because one of the primary functions of the BBB is to prevent excitoxic insult. I do not know how much NMDA penetrates the BBB per mg taken orally, but I do know that it will be less than an equivalent amount of DAA due to the active transport of AAs at the barrier. Assuming some methylation of DAA and conversion to NMDA in the brain (mediated endogenously of course), it's likely that the dose of NMDA provided by intimidate will be met through basic DAA supplementation (this assumes a 1% conversion rate). So, in my opinion, excitotoxicity is unlikely with intimidate.
The above is my own opinion and does not reflect the opinion of PES
07-24-2012, 07:48 PM
07-25-2012, 02:00 AM
07-25-2012, 02:01 AM
07-25-2012, 03:32 AM
I recommend taking an equal amount of time off between running the two. Running the two back to back would be equivalent (or dam close) to running one of them for 8 weeks.Originally Posted by JonRubio
Serious Nutrition Solutions
Revolutionizing Sports Nutrition, One Product At A Time
antihero [@] SeriousNutritionSolutions.com
07-25-2012, 07:01 AM
07-25-2012, 07:27 AM
07-25-2012, 09:08 AM
07-25-2012, 12:46 PM
07-25-2012, 01:38 PM
Bump. I will be trying Intimidate now ! Been thru a few tubs of DAA. It really works if you take off 2-3 weeks in btw uses ( for me personally). Thanks!
Also, can I use Erase w/ Intimidate ? And what about Shift ?
07-25-2012, 01:44 PM
07-25-2012, 02:30 PM
07-25-2012, 04:26 PM
I used tcf1 daa and Prurus labs daa both worked I had better success with tcf1 though maybe the liquid vade delivery ..
However I did like daa but their was one side I got and that was bloat from both I used them both with erase aswell ..
For this reason I am looking forward to using intimidate and I don't think the price is much of a difference unless you really are poor 30 quid for a month supply that will do me.
Plus I like the fact intimidate is just one pill before sleep as I work nights so that's a plus for me
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