Chlorogenic acid (Green Coffee Bean) for fat loss

  1. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Chlorogenic acid (Green Coffee Bean) for fat loss


    The other thread is trashed...

    So let's try again.

    Thoughts? Feedback?

    I read the mechanisms involved. They are largely based on glucose metabolism/modulation (post-prandial). So, would this not work as well for the keto crowd since we don't ingest a bunch of carbs anyway?

    I also ran across this this study on adverse homocysteine levels imparted by Chlorogenic Acid http://www.ncbi.nlm.nih.gov/pubmed/11237928
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  2. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Thank you. There are a couple studies on Svetol which is a caffeine free form of Green Coffee Bean extract that contains a high percentage of chlorogenic acid. Interestingly the human study showed positive weight loss effects in overweight people. But the rat study conducted later did not.

    I didn't know that homocysteine thing. Got a reference?
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  3. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Only reference I have is the Pub Med link I posted

    Quote Originally Posted by Royd The Noyd View Post
    I didn't know that homocysteine thing. Got a reference?
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
    •   
       

  4. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by Whacked View Post
    Only reference I have is the Pub Med link I posted
    Weird I don't think that was there when I first posted
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  5. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    ALL good haha
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  6. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,637
    Rep Power
    1594941
    Level
    67
    Lv. Percent
    1.07%
    Achievements Activity ProActivity AuthorityPosting Pro

    i like chlorogenic acid, i dont use more then 500mg of it (1g green coffe bean 50%).

    not necessary IMO.

    7 oxo works better at 200mg per day. Easily put into a nice topical. However topically youll notice an effect locally rather then all around.

    200mg 7 oxo orally is nice as well.

    for chlorogenic acid it also effects the 11b HSD1 which happens to be a good thing since its expression is in excess during high stress times.
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  7. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by EBF Inc View Post
    i like chlorogenic acid, i dont use more then 500mg of it (1g green coffe bean 50%).

    not necessary IMO.

    7 oxo works better at 200mg per day. Easily put into a nice topical. However topically youll notice an effect locally rather then all around.

    200mg 7 oxo orally is nice as well.

    for chlorogenic acid it also effects the 11b HSD1 which happens to be a good thing since its expression is in excess during high stress times.
    How does a systemic drug act locally?
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  8. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,637
    Rep Power
    1594941
    Level
    67
    Lv. Percent
    1.07%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by Royd The Noyd View Post
    How does a systemic drug act locally?
    probqbly should have been more specific,

    The effects of topical 7 oxo, is more pronounced where you apply rather then all over your body.
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  9. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Makes sense. Same logic as "Clenviscerate"

    Back OT: Can anyone answer my question?


    """I read the mechanisms involved. They are largely based on glucose metabolism/modulation (post-prandial). So, would this not work as well for the keto crowd since we don't ingest a bunch of carbs anyway?""


    Quote Originally Posted by Royd The Noyd View Post
    How does a systemic drug act locally?
    Quote Originally Posted by EBF Inc View Post
    probqbly should have been more specific,

    The effects of topical 7 oxo, is more pronounced where you apply rather then all over your body.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  10. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,637
    Rep Power
    1594941
    Level
    67
    Lv. Percent
    1.07%
    Achievements Activity ProActivity AuthorityPosting Pro

    it will still work for a keto crowd due to the effects on cortisol, especially in the begining phase of the ketogenic diet.

    im unsure of its affect on PI3K/Akt so i cant answer its effect on insuline secretion as of yet if its function is a purporse of blocked digestion.

    If it reduces Akt then you reduce adipogenisis. Stearic acid and other saturated fats increase Akt (similar to the way carb and insulin interact with PI3K/Akt pathway). So if it affect Akt thn yes it will be a positive effect as itll repress adipogenesis in presense of a high fat diet.

    But there are also other thinks like the ERK1/2 pathway phosphorylation. so there are many mechanisms that need to be looked at before we can truely see.
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  11. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by EBF Inc View Post
    it will still work for a keto crowd due to the effects on cortisol, especially in the begining phase of the ketogenic diet.

    im unsure of its affect on PI3K/Akt so i cant answer its effect on insuline secretion as of yet if its function is a purporse of blocked digestion.

    If it reduces Akt then you reduce adipogenisis. Stearic acid and other saturated fats increase Akt (similar to the way carb and insulin interact with PI3K/Akt pathway). So if it affect Akt thn yes it will be a positive effect as itll repress adipogenesis in presense of a high fat diet.

    But there are also other thinks like the ERK1/2 pathway phosphorylation. so there are many mechanisms that need to be looked at before we can truely see.
    Clen is systemic.

    When has chlorogenic acid been shown to reduce cortisol? And in what tissue? The only way it helps at the beginning is that it may get you to ketosis faster is if you are eating carbohydrates. Which nobody does at the start of a Keto diet.

    Whacked its not very useful, like you thought, in that circumstance. Unless it has other MOA's, but the latest green coffee Bean extract study that everyone was excited about indicated its primary moa is as a "carb blocker"
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  12. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Phaseolamine (white northern kidney bean extract) does that quite well via amylase inhibition and we all know how well that all went

    Quote Originally Posted by Royd The Noyd View Post
    . Unless it has other MOA's, but the latest green coffee Bean extract study that everyone was excited about indicated its primary moa is as a "carb blocker"
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  13. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,637
    Rep Power
    1594941
    Level
    67
    Lv. Percent
    1.07%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by Royd The Noyd

    Clen is systemic.

    When has chlorogenic acid been shown to reduce cortisol? And in what tissue? The only way it helps at the beginning is that it may get you to ketosis faster is if you are eating carbohydrates. Which nobody does at the start of a Keto diet.

    Whacked its not very useful, like you thought, in that circumstance. Unless it has other MOA's, but the latest green coffee Bean extract study that everyone was excited about indicated its primary moa is as a "carb blocker"
    http://www.endocrine-abstracts.org/e...ea0028p189.htm
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  14. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,637
    Rep Power
    1594941
    Level
    67
    Lv. Percent
    1.07%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by Royd The Noyd

    Clen is systemic.

    When has chlorogenic acid been shown to reduce cortisol? And in what tissue? The only way it helps at the beginning is that it may get you to ketosis faster is if you are eating carbohydrates. Which nobody does at the start of a Keto diet.

    Whacked its not very useful, like you thought, in that circumstance. Unless it has other MOA's, but the latest green coffee Bean extract study that everyone was excited about indicated its primary moa is as a "carb blocker"
    G6P Translocase Inhibitors Block Microsomal 11 ?-HSD1 Activity-- To determine whether microsomal 11 ?-HSD1 activity was dependent on transport-dependent G6P uptake/metabolism we examined 11 ?-HSD1 activity in whole microsomes with and without specific inhibitors of G6P uptake (chlorogenic acid or phlorizin). As an additional control for the specificity of G6P transport/metabolism, we tested the effect of an alternative sugar phosphate (galactose-1-phosphate). As shown using liver microsomes (Fig. 7), chlorogenic acid caused a 96% decrease in G6P-stimulated 11 ?-HSD1 activity, whereas Gal-1-P was ineffective

    http://m.jbc.org/content/281/1/341.full
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  15. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Good stuff EBF!

    Here is the antithesis of a scientic post but.......

    Amazon.com rated the stuff VERY POORLY.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  16. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    That's okay, but both groups saw significant losses in abdominal fat, and waist circumference...suggesting the 11beta-hsd inhibition negligible.
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  17. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Wouldn't that suggest the polar opposite? I was under the impression that cortisol-related lipogenesis did in fact present as fat accumulation in the abdominal region aka truncal obesity.


    Quote Originally Posted by Royd The Noyd View Post
    That's okay, but both groups saw significant losses in abdominal fat, and waist circumference...suggesting the 11beta-hsd inhibition negligible.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  18. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by Whacked View Post
    Wouldn't that suggest the polar opposite? I was under the impression that cortisol-related lipogenesis did in fact present as fat accumulation in the abdominal region aka truncal obesity.
    No because they found no decrease in urinary cortisol in the black coffee group. They actually saw an increase. But both groups saw significant statistical fat loss. I don't have the full text though so maybe there is something else in there. It's a weird journal. Not on pubmed or medline.
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  19. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Is urinary decrease or increase necessarily the be all end all "proof' that cortisol levels have been manipultated? Thanks
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  20. Board Sponsor
    Royd The Noyd's Avatar
    Join Date
    May 2008
    Posts
    5,319
    Rep Power
    775527
    Level
    57
    Lv. Percent
    92.62%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by Whacked View Post
    Is urinary decrease or increase necessarily the be all end all "proof' that cortisol levels have been manipultated? Thanks
    It's suggestive. That's really all though.
    ForeRunner Labs
    The Future of Human Performance
    Please LIKE FRL on Facebook

  21. Professional Member
    Geoforce's Avatar
    Join Date
    Feb 2012
    Posts
    3,892
    Rep Power
    1188975
    Level
    58
    Lv. Percent
    41.78%
    Achievements Activity ProActivity AuthorityPosting Pro

    What about God though?

    Just playing, good stuff so far guys, very informative. Subbed to read more later!
    EvoMuse Products Rep

    PM me with any questions!
  22. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    If I was a mod, Id bad you

    BACK OT PLZ!!!!!!!!!!!!!!!!!!!!!!!!!!! !

    haha

    Quote Originally Posted by Geoforce View Post
    What about God though?

    Just playing, good stuff so far guys, very informative. Subbed to read more later!
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  23. Professional Member
    Geoforce's Avatar
    Join Date
    Feb 2012
    Posts
    3,892
    Rep Power
    1188975
    Level
    58
    Lv. Percent
    41.78%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by Whacked View Post
    If I was a mod, Id bad you

    BACK OT PLZ!!!!!!!!!!!!!!!!!!!!!!!!!!! !

    haha
    Lol if that comment gets this thread off track I'll self ban myself! Only product I have used with GCB extract is Abliderate Advanced.
    EvoMuse Products Rep

    PM me with any questions!
  24. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    LOL

    topicals have their place but this is a whole diff animal as you know
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  25. Professional Member
    Geoforce's Avatar
    Join Date
    Feb 2012
    Posts
    3,892
    Rep Power
    1188975
    Level
    58
    Lv. Percent
    41.78%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by Whacked View Post
    LOL

    topicals have their place but this is a whole diff animal as you know
    Certainly. Was simply saying that I haven't had any time to do my usual experiments by me taking the the product! It is certainly interesting though and something I may experiment more with in the future. I like some of the reading in this thread so far, I'm learning!
    EvoMuse Products Rep

    PM me with any questions!
  26. Team Anabolic
    UNCnate's Avatar
    Join Date
    Sep 2006
    Posts
    1,292
    Rep Power
    25884
    Level
    27
    Lv. Percent
    78.81%
    Achievements Posting Pro

    We just added this to our line. Hopefully we will have it in stock very soon so I can try it out.

  27. Elite Member
    Whacked's Avatar
    Stats
    5'11"  210 lbs.
    Join Date
    Apr 2006
    Posts
    5,508
    Rep Power
    536781
    Level
    57
    Lv. Percent
    22.35%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Ditto

    Quote Originally Posted by Geoforce View Post
    Certainly. Was simply saying that I haven't had any time to do my usual experiments by me taking the the product! It is certainly interesting though and something I may experiment more with in the future. I like some of the reading in this thread so far, I'm learning!
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
  28. Professional Member
    PrepNwa23's Avatar
    Stats
    5'10"  174 lbs.
    Join Date
    Feb 2008
    Posts
    4,360
    Rep Power
    2760981
    Level
    68
    Lv. Percent
    58.34%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by UNCnate
    We just added this to our line. Hopefully we will have it in stock very soon so I can try it out.
    Yes I wanted it for the sale you guys were doing. I want to try it.
    PES Representative
    The above is my own opinion and does not reflect the opinion of PES
  29. Diamond Member
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,014
    Rep Power
    33558
    Level
    62
    Lv. Percent
    81.86%
    Achievements Activity AuthorityActivity ProPosting ProPosting AuthorityPosting Veteran

    Quote Originally Posted by EBF Inc View Post
    i like chlorogenic acid, i dont use more then 500mg of it (1g green coffe bean 50%).

    not necessary IMO.

    7 oxo works better at 200mg per day. Easily put into a nice topical. However topically youll notice an effect locally rather then all around.

    200mg 7 oxo orally is nice as well.

    for chlorogenic acid it also effects the 11b HSD1 which happens to be a good thing since its expression is in excess during high stress times.
    great news I did not know chlorogenic acid effects 11b hsd1! Im excited to try this one soon

    Quote Originally Posted by UNCnate View Post
    We just added this to our line. Hopefully we will have it in stock very soon so I can try it out.
    Yup its in stock
    http://www.youtube.com/watch?v=8XVnJ_g9NLc
    heres a video from Dr OZ
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness
  30. New Member
    jewgold's Avatar
    Stats
    5'8"  190 lbs.
    Join Date
    Mar 2012
    Posts
    193
    Rep Power
    50099
    Level
    17
    Lv. Percent
    7.53%

    this stuff seems to be promising more and more
  31. Diamond Member
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,014
    Rep Power
    33558
    Level
    62
    Lv. Percent
    81.86%
    Achievements Activity AuthorityActivity ProPosting ProPosting AuthorityPosting Veteran

    Quote Originally Posted by jewgold View Post
    this stuff seems to be promising more and more
    I know I cant wait to try it

    I did the raspberry ketones, green tea magic matcha, and Africa mango stack the past two months and while I have been eating above the limit I set for myself by only like 100 -200 calories on some days, I have stayed about the same. I like to use these fat oss products when I am in the "offseason" to keep me staying lean.
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness
  

  
 

Similar Forum Threads

  1. Green Coffee Bean & Weight Loss
    By JudoJosh in forum Supplements
    Replies: 32
    Last Post: 05-28-2012, 04:41 PM
  2. Alpha Lipoic Acid for Fat Loss
    By Royd The Noyd in forum Supplements
    Replies: 2
    Last Post: 12-06-2010, 06:10 AM
  3. Injecting Acetic Acid for Fat Loss
    By pillpopper in forum OTC Drug
    Replies: 14
    Last Post: 11-09-2010, 01:43 PM
  4. lactic acid training for fat loss
    By gym88 in forum Weight Loss
    Replies: 34
    Last Post: 04-01-2008, 11:17 AM
  5. Arimidex doses for fat loss?
    By smokinghawk in forum Anabolics
    Replies: 5
    Last Post: 01-08-2003, 06:22 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in