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uvawahoowa
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I know there are products that handle cortisol control, like lean xtreme, ergobolic, etc. But what is the best ingredient for such? I believe 7-keto is one...anything else?
L-dopa has been shown to help control or even lower cortisol.I know there are products that handle cortisol control, like lean xtreme, ergobolic, etc. But what is the best ingredient for such? I believe 7-keto is one...anything else?
ashwaghanda been shown to reduce cortisol?7-keto (Reduce XT), 5-AT, ashwaghanda, and sutherlandia fructescens are all good options
I know there are products that handle cortisol control, like lean xtreme, ergobolic, etc. But what is the best ingredient for such? I believe 7-keto is one...anything else?
help your body to adapt to stress ( regulate the excess in cortisol)ashwaghanda been shown to reduce cortisol?
Yep, in an adaptogenic manner (similar to sutherlandia).ashwaghanda been shown to reduce cortisol?
Erase Pro is not an ingredient as the OP was inquiring about.Erase Pro seems to do the trick for me. It's not cheap ~$50 for a month's supply. I started stacking Erase Pro with DAA. I have some anger issues so I was worried about the effects of DAA ( 3 grams/day ). So far I haven't felt mood or anger from the DAA ( I'm about 3 weeks into the DAA ).
I started the Erase Pro at the same time as DAA. At first I started with every other day dosing - 1 pill Erase Pro with biggest meal. I quickly went to every day since I was enjoying the effects of the DAA/Erase Pro combo. In fact the first couple of days Erase Pro was making me so mellow I kept taking naps. I have a noticably lowered level of stress / cortisol.
I think you can get the older Erase pills for a lot less but there is definitely some strong cortisol lowering with the Pro version. Some body builders report that every day dosing of Erase Pro dries out their joints. Haven't had that problem. I take 4 grams norwegian cod liver oil or fish oil every day - it's supposed to help.
It's primary MOA is not cortisol inhibition either.Erase Pro is not an ingredient as the OP was inquiring about.
None of those products have ingredients with evidence that they reduce cortisol.Free Test, Erase, IGF 2 (Ldopa)
Please explain about what happenedI wouldn't say erase pro lowers cortisol as when I used it with daa I actually put on weight around my hips using erase pro dried my joints out quickly ...
I can see it being good for pct daa and erase pro helped me gain weight but as for cortisol control nope doesn't do that
900mg is the suggested amountmaybe 1200mg of phosphatidylserine.
None of those products have ingredients with evidence that they reduce cortisol.
Currently using 7-Keto as well as ashwaghanda. If you take this, especially when you take an AI pick up some cissus...my joints are getting quazi dried out.7-keto (Reduce XT), 5-AT, ashwaghanda, and sutherlandia fructescens are all good options
Awesome exactly what I was looking for, thanks yet again!7-keto (Reduce XT), 5-AT, ashwaghanda, and sutherlandia fructescens are all good options
Please link me to evidence on either ingredient (peer-reviewed study, not anecdote).Free Test and IGF-2 both have ingrediants that have been shown to help control/lower cortisol.
Freetest has 3,7 Keto DHEA. 7-Keto derivatives competitively interact with the 11beta-HSD1 enzyme, which is the enzyme that allows the transfer of inactive glucocorticoids to active ones. This is important as it therefore helps keep cortisol levels lower than normal by slowing (but not stopping) the conversion of inactive cortisol to active cortisol - allowing for mitigated levels of this catabolic hormone.
Also IGF has L-dopa which has numerous studies on it and it's effects on cortisol.
jdg76
Team APNUT
This has zero relevance to healthy populations. L-dopa is a well-documented treatment for a myriad of Parkinson's disease symptoms.Having a hard time linking it right because it is coming from a database at my college. I understand this one is on Parkinson's disease, but here is a few..
Acute levodopa administration reduces cortisol release in patients with Parkinson’s disease. Authors:Müller, T.[SUP]1[/SUP] [email protected]
Welnic, J.[SUP]1[/SUP]
Muhlack, S.[SUP]1[/SUP]Source:Journal of Neural Transmission; Mar2007, Vol. 114 Issue 3, p347-350, 4pDocument Type:ArticleSubject Terms:*DRUGS -- Administration
*DOPA
*PARKINSON'S disease
*PATIENTS
*HYDROCORTISONE
*BRAIN stem
*NERVOUS systemAuthor-Supplied Keywords:cortisol
levodopa
Parkinson’
Parkinson's disease
s diseaseAbstract:Levodopa (LD) application improves motor symptoms in patients with Parkinson’s disease (PD) patients. Little is known on further effects of LD, which induced lower plasma levels of cortisol and lower serotonergic activity in certain brain areas of fish. Objectives of this trial were to analyse levels of cortisol, LD and 3-O-methyldopa (3-OMD) after administration of LD/benserazide in long term treated PD patients. 12 PD patients, taken off their regular treatment for at least 12 hours, received soluble 200 mg LD/50 mg benserazide under stress free conditions. Motor symptoms improved, LD and 3-OMD levels increased, whereas cortisol concentrations started to decrease significantly 30 minutes after LD intake. This reduced cortisol release may result from an overflow of exogenous LD in the brainstem. This hypothetically causes an reduced 5-HT content in neurons projecting to the hypothalamic structures, which are involved in the partial 5-HT dependent central regulation of peripheral cortisol release. [ABSTRACT FROM AUTHOR] Copyright of Journal of Neural Transmission is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)Author Affiliations:[SUP]1[/SUP]Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.ISSN:03009564DOI:10.1007/s00702-006-0552-0Accession Number:24157246Database:Academic Search Premier
I'm not completely sold on Erase Pro, especially from a "value" perspective. I'm thinking of trying to source its alleged cortisol lowering ingredient directly since I think I need cortisol management - I have adrenal fatigue from years of grande coffee drinks and 20 oz. diet pepsi's and Dr. Pepper's.^Pretty inaccurate lol
For sure one of my favorites also, been a solid product for a long time now.Reduce xt is my fav
AmenFor sure one of my favorites also, been a solid product for a long time now.
I highly doubt that product contains effective doses of any...thing.I was going to throw my hat in and vote Erase (original formula) primary ingredient - Androsta-3,5-diene-7,17-dione.
But after reading the entire thread and seeing ashwaghanda, DHEA, 7-Keto DHEA etc I use another product that contains all these in one formula, although I didnt buy it for cortisol control.
The product: High Energy Labs HGH Complete
Ingredients:
Secretagen Proprietary Growth Enhancer/Releaser Complex: Tribulus )Tribulus terrestris) fruit extract, GABA (gamma-aminobutyric acid), Asddhwaganda (Withaniasmnifera), (root), Alpha GPC (L-alpha-glycerylphosphosphroylcholine), Mucuna Pruriens (bean extract )[15%] L-Dopa, Maca (Lepidium meyenill) (root), 7KETO (3-aceetyl-7-oxo dehydroepiandrosterone), Micronized DHEA (Dehydroepiandronsterone), Zinc (as OpticZinc), MSM (Methyl-Sulfonyl-Methane), Copper Citrate, Melatonin, Chromium Polynicotinate (as Chromemate)
Proprietary Antioxidant Complex: Ascorbic acid (Vit C), Alpha Lipoic Acid SOD (Superoxide Dismutase) Citrus Bioflavonoids, CoEnzyme Q-10
Now I just bought it and it hasnt arrived yet in the mail so I'm hoping once it arrives that all those ingredients do the trick, especially if I keep taking Erase.
Exactly what I was thinkingI highly doubt that product contains effective doses of any...thing.
Thanks Boss!Directly below relates to DHEA, but at the bottom it shows how the 7-Keto analogues share the same characteristics-look at the very bottom in bold for the receptor physiology- it doesn't paint the total picture, but shows how the molecular structures interact and why 7-Ketosteroids have an affinity for 11b-HSD:
"Dehydroepiandrosterone (DHEA) is freely available in Northern America and taken as an additive hormone for general well being. DHEA has been reported to exert "anti-glucocorticoid" effects by lowering blood glucose levels and improving insulin sensitivity in obese rodents and humans, resembling the effects of peroxisome proliferator-activated receptor-gamma (PPARγ) ligands; however, the underlying mechanisms are not fully understood. In differentiated 3T3-L1 adipocytes and in white adipose tissue and in liver of C57BL/6J mice, we found that DHEA causes down-regulation of 11β-HSD1 (the enzyme responsible for the local reactivation of glucocorticoids) and dose-dependent reduction of its reductase activity. Hexose-6-phosphate dehydrogenase was also down-regulated in these cells and tissues. The effects of DHEA were comparable with those of the PPARγ agonist rosiglitazone but not additive. Analysis of the transcription factors involved in the DHEA-dependent regulation of 11β-HSD1 expression revealed a switch in CCAAT/enhancer-binding protein (C/EBP) expression. C/EBPα, a potent activator of 11β-HSD1 gene transcription, was down-regulated in 3T3-L1 adipocytes and in liver and adipose tissue of DHEA-treated mice, whereas C/EBPβ and C/EBPδ, attenuating the effect of C/EBPα, were unchanged or elevated. Our results further suggest a protective effect of DHEA on adipose tissue by up-regulating PPARα and down-regulating leptin, thereby contributing to the reduced expression of 11β-HSD1.
We also investigated effects of DHEA on 11β-HSD2-dependent glucocorticoid inactivation in cells and animal models. DHEA treatment markedly increased mRNA expression and activity of 11β-HSD2 in RCCD2 rat renal cortical collecting duct cells and in kidneys of C57BL/6J mice and Sprague-Dawley rats. DHEA-treated rats tended to have reduced urinary corticosterone to 11-dehydrocorticosterone ratios. The effect of DHEA on 11β-HSD2 is likely due to altered transcriptional regulation. It involves activation of the PI3K/Akt pathway and a shift of the ratio of C/EBP expression from C/EBPα to C/EBPβ, primarily as a result of increased C/EBPβ mRNA and protein expression. C/EBPα and C/EBPβ differentially regulate the expression of 11β-HSD1 and 11β-HSD2. The DHEA-induced decrease of the ratio of active to inactive glucocorticoids provides a possible explanation for the anti-glucocorticoid effects of DHEA.
Related publications:
Apostolova G, Schweizer RA, Balazs Z, Kostadinova RM, Odermatt A, Dehydroepiandrosterone Inhibits the Amplification of Glucocorticoid Action in Adipose Tissue. Am J Physiol Endocrinol Metab. 2005 May;288(5):E957-64.
Balazs Z, Schweizer RAS, Frey FJ, Jeanrenaud-Rohner F, and Odermatt A, Dehydroepiandrosterone induces the expression and activity of 11β-hydroxysteroid dehydrogenase type 2 in the kidney by acting on CCAAT/enhancer binding proteins. J Am Soc Nephrol 2008 Jan; 19(1):92-101.
Alternative substrates for 11β-HSD1
Rapid hepatic metabolism of 7-ketocholesterol by 11β-HSD1
We demonstrated a role for 11β-HSD1 in the metabolism of 7-ketocholesterol (7KC), one of the major dietary oxysterols. Comparison of recombinant 11β-HSD1, transiently expressed in human embryonic kidney 293 cells, revealed the stereo-specific formation of 7β-hydroxycholesterol from 7KC by rat and human 11β-HSD1, whereas the hamster enzyme formed 7α-hydroxycholesterol and 7β-hydroxycholesterol. While lysates efficiently catalyzed both oxidation and reduction, intact cells exclusively reduced 7KC. These findings were confirmed using rat and hamster liver homogenates, intact rat hepatocytes, and intact hamster liver tissue slices. Reduction of 7KC was abolished upon inhibition of 11β-HSD1.
In vivo, after gavage feeding rats, 7KC rapidly appeared in the liver and was converted to 7β-hydroxycholesterol. Carbenoxolone significantly decreased the ratio of 7β-hydroxycholesterol to 7KC, indicating 11β-HSD1-dependent reduction of 7KC to 7β-hydroxycholesterol. Upon inhibition of 11β-HSD1 by carbenoxolone, 7KC tended to accumulate in the liver, and plasma 7KC concentration increased. Together, 11β-HSD1 efficiently catalyzes the first step in the rapid hepatic metabolism of dietary 7KC, which may explain why dietary 7KC has little or no effect on the development of atherosclerosis.
Related publication:
Schweizer, R. A. S., Zürcher, M., Balazs, Z., Dick, B., and Odermatt, A. (2004) Rapid Hepatic Metabolism of 7-Ketocholesterol by 11β-Hydroxysteroid Dehydrogenase Type 1. J. Biol. Chem., 279, 18415-18424.
The role of H6PDH in the 11β-HSD1-dependent metabolism of 7-keto- and 7β-hydroxy-neurosteroids
Several studies suggest that 7-keto- and 7-hydroxysteroids exert neuroprotective, anti-glucocorticoid and immune-modulatory effects. We recently demonstrated that 11β-HSD1 functions in a reversible way and efficiently catalyzes the interconversion of 7-keto- and 7-hydroxyneurosteroids in intact cells. In the presence of H6PDH, 11β-HSD1 predominantly converted 7-keto-DHEA and 7-ketopregnenolone into their corresponding 7β-hydroxy metabolites, indicating a role for H6PDH and 11β-HSD1 in the local generation of 7β-hydroxyneurosteroids. 3D-structural modeling offered an explanation for the preferred formation of 7β-hydroxyneurosteroids. Our results from experiments determining the steady state concentrations of glucocorticoids or 7-oxygenated neurosteroids suggested that the equilibrium between cortisone and cortisol and between 7-keto- and 7-hydroxyneurosteroids is regulated by 11β-HSD1 and greatly depends on the coexpression with H6PDH. Thus, the impact of H6PDH on 11β-HSD1 activity has to be considered for understanding both glucocorticoid and neurosteroid action in different tissues. The A ring of 7β-hydroxy-DHEA (7β-OH-DHEA) is oriented towards the interior of 11β-HSD1. The C7β-hydroxyl in 7β-hydroxy-DHEA superimposes nicely on the C11β-hydroxyl in corticosterone with equal predicted distances to C4 of the nicotinamide ring and the hydroxyl of the catalytic tyrosine.
Related publication:Nashev LG, Chandsawangbhuwana C, Balazs Z, Atanasov AG, Dick B, Frey FJ, Baker ME, and Odermatt A. Hexose-6-phosphate Dehydrogenase Modulates 11β-Hydroxysteroid Dehydrogenase Type 1-dependent Metabolism of 7-keto- and 7β-hydroxyneurosteroids PloS ONE 2007 Jun 27; 2:e561.
You should be cycling off L-dopa. Time on < time off, really. Also, you should consider using 5htp and egcg while using l-dopa. lastly, mucuna pruriens, not l-dopa (yes, there is an important distinction), has evidence that it increases T levels in healthy humans. I have seen zero evidence that it raises estrogenhey guys I love l dopa supps. I ve taken powerful, hghup, igf2. I ve gotten really nice strenght gains from all of them. Does anyone get scared that manipulating your l dopa levels is dangerous? I ve heard that since this isn t synthetic l dopa it s safe.
Also i ve seen that daa has become pretty popular and i ve read that it def can increase your test. But i ve also heard that it can increase your estrogen lvls as well to where it kinda isn t worth it. Any thoughts on this guys. Thanks for your time guys.
^^ Coop hit the nail on the head.You should be cycling off L-dopa. Time on < time off, really. Also, you should consider using 5htp and egcg while using l-dopa. lastly, mucuna pruriens, not l-dopa (yes, there is an important distinction), has evidence that it increases T levels in healthy humans. I have seen zero evidence that it raises estrogen
Glycyrrhetinic acid
EDIT: Not the best, but hasn't been mentioned before.
So if I used 7 keto for short term cortisol control, I would dose something like 500mg AM upon waking and another 500mg pre bed? Would this have any effect on strength workouts mid day? My bench and a few other compound lifts have gone down and I think it may be related to cortisol creating a catabolic environment7-keto (Reduce XT), 5-AT, ashwaghanda, and sutherlandia fructescens are all good options
Does that actually work?Anyone still use Vitamin C?
I wouldn't waist my time or money.Does that actually work?
It really doesn't work in weight training populations unless you're overtrainingAnyone still use Vitamin C?
Is there evidence that vitamin c and patethine help reduce the conversion of dhea to cortisol?It really doesn't work in weight training populations unless you're overtraining
Has it been tested for cortisol modulation in weight training populations?It really doesn't work in weight training populations unless you're overtraining
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