Recompadrol's PPAR-Alpha agnostic activity
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07-09-2012, 10:51 AM
Relevant to Sesamin users... New one :
Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats.
Ide T, et al. Show all
Eur J Nutr. 2012 Jun 30. [Epub ahead of print]
Department of Food and Nutrition, Faculty of Human Life, Jumonji University, 2-1-28 Sugasawa, Niiza, Saitama, 352-8510, Japan, [email protected].
Abstract PURPOSE: Dietary sesamin (1:1 mixture of sesamin and episesamin) decreases fatty acid synthesis but increases fatty acid oxidation in rat liver. Dietary α-lipoic acid lowers hepatic fatty acid synthesis. These changes can account for the serum lipid-lowering effect of sesamin and α-lipoic acid. It is expected that the combination of these compounds in the diet potentially ameliorates lipid metabolism more than the individual compounds. We therefore studied the combined effect of sesamin and α-lipoic acid on lipid metabolism in rats.
METHODS: Male Sprague-Dawley rats were fed diets supplemented with 0 or 2 g/kg sesamin and containing 0 or 2.5 g/kg α-lipoic acid for 22 days.
RESULTS AND CONCLUSIONS: Sesamin and α-lipoic acid decreased serum lipid concentrations and the combination of these compounds further decreased the parameters in an additive fashion. These compounds reduced the hepatic concentration of triacylglycerol, the lignan being less effective in decreasing this value. The combination failed to cause a stronger decrease in hepatic triacylglycerol concentration. The combination of sesamin and α-lipoic acid decreased the activity and mRNA levels of hepatic lipogenic enzymes in an additive fashion. Sesamin strongly increased the parameters of hepatic fatty acid oxidation enzymes. α-Lipoic acid antagonized the stimulating effect of sesamin of fatty acid oxidation through reductions in the activity of some fatty acid oxidation enzymes and carnitine concentration in the liver. This may account for the failure to observe strong reductions in hepatic triacylglycerol concentration in rats given a diet containing both sesamin and α-lipoic acid.
PMID 22752262 [PubMed - as supplied by publisher
07-09-2012, 12:47 PM
Love the science.
I am looking into various options for new product based on what everyone wants to see
07-09-2012, 07:21 PM
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07-10-2012, 09:40 AM
A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
"The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction" Proverbs 1:7
07-10-2012, 10:49 AM
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07-10-2012, 01:26 PM
Pretty sure MAN has it in therd fish oil product as well.
E-Pharm Rep... PM me with any questions or concerns
07-10-2012, 01:29 PM
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