From my post on another board:
It is not. The study in question was done in vitro as opposed to the rat studies done on lipolysis, which are certainly of signficantly greater merit.
Also, here is PA's take on RKs and anti-androgens:
"your hypothalamus has androgen receptors. it also has estrogen and progesterone receptors, and all of these will bind to circulating sex hormones. When they bind and activate they initiate the negative feedback signal. If you block them and prevent their activation then you will block the negative feedback and your sex hormone production will go up
i think you just forgot the fact that your HPTA works via receptors"
^He is basically saying that T production will go up (which is theoretically beneficial given the HL of RKs). Now I'm not entirely sure if that applies to what we are doing, but consider this:
Green Tea Extract is estrogenic IN VIVO (rats and cancer patients). This should be of a much larger concern than RKs, yet this is overlooked simply because Green Tea Extract has SO MANY benefits in spite of its low oral bioavailability. The same applies to RKs, though in my opinion, the pros (overall health + potential as a lipolytic agent) outweigh the possible cons to an even further degree. If you are concerned about possible androgen antagonism (which I feel you should not be, based on the single in vitro study), I would simply supplement LCLT to increase androgen receptor density. Either way, the difference is transient and really not worth noting."