amino receptors

[David Dunn]

OK. Why?

[grngoloco]

OK. Why?

I read bcaa's need insulin for absorption,,, not sure how or why...

[grngoloco]

I read bcaa's need insulin for absorption,,, not sure how or why...

Specifically,, low insulin inhibits ansorption into muscle tissue

[David Dunn]

That is different than (digestive) absorption.

Insulin (glycogen) shuttles aminos into the muscle after absorption. But there is also a thing called glycogenesis where in the body will convert protein/aminos into glycogen in its absence.

[grngoloco]

That is different than (digestive) absorption.

Insulin (glycogen) shuttles aminos into the muscle after absorption. But there is also a thing called glycogenesis where in the body will convert protein/aminos into glycogen in its absence.

LOL... Like I said, I don't post queries about stuff I already know!

[grngoloco]

Well,, I'll keep taking my aminos individually on an empty stomach,as best I can... wherever it occurs,, there definitely seems to be evidence of competition,, nothing makes me more mad than expensive toilet water

[mr.cooper69]

Dude, these receptors you are referring to are not broad-spectrum amino acid receptors for dietary protein that you ingest. They are specific receptors for metabolic processes in the body. I'm sorry, but you can't cite activity at the NMDA receptor and thus psotulate that there are "amino acid receptors." There aren't.

[mr.cooper69]

Ok,, it is my understanding that bcaa's do not act the same way upon ingestion as, let's say, arginine, ornithine or glutamine

That is correct, and has nothing to do with receptors.

Let me clear up what's happening in the small intestine. After peptide cleavage at a variety of primary levels (pepsin in the stomach, pancreatic release of trypsin/chymotrypsin in the duodenum), we have a bunch of small di and tri peptides. From here, these peptides are further cleaved into individual amino acids at the level of the microvilli by enzymes that we will refer to collectively as "brush-border enzymes" for simplicity. However, di/tri peptides can also enter the enterocyte, at which point enzymes within the cell will reduce them to amino acids. No peptides will enter the bloodstream following intestinal absorption; one way or another, they will be individual amino acids.

Here's a nice image depicting this:



And here's a description from one of my textbooks showing how exactly amino acids are absorbed. I had a much better textbook with an image showing means of absorption for each individual EAA, but I'm on break and don't have access to it. You can PM me in a week if you're still interested.

[grngoloco]

Dude, these receptors you are referring to are not broad-spectrum amino acid receptors for dietary protein that you ingest. They are specific receptors for metabolic processes in the body. I'm sorry, but you can't cite activity at the NMDA receptor and thus psotulate that there are "amino acid receptors." There aren't.

I think I was talking about transporters and not receptors,, relax a bit,, I'm not as biochemistry educated as a lot of y'all

[mr.cooper69]

I think I was talking about transporters and not receptors,, relax a bit,, I'm not as biochemistry educated as a lot of y'all

Ok. So what about transporters are you concerned about? Transporters on what level (i.e. intestine, capillary, liver, myocyte, etc..)?

[grngoloco]

Thanks for all the input,,, I came to AM to learn, not put my vast knowledge on display,,, I really do take everything people tell me and put it to further research,,, again, thanks

[bigdavid]

That is correct, and has nothing to do with receptors.

Let me clear up what's happening in the small intestine. After peptide cleavage at a variety of primary levels (pepsin in the stomach, pancreatic release of trypsin/chymotrypsin in the duodenum), we have a bunch of small di and tri peptides. From here, these peptides are further cleaved into individual amino acids at the level of the microvilli by enzymes that we will refer to collectively as "brush-border enzymes" for simplicity. However, di/tri peptides can also enter the enterocyte, at which point enzymes within the cell will reduce them to amino acids. No peptides will enter the bloodstream following intestinal absorption; one way or another, they will be individual amino acids.

Here's a nice image depicting this:



And here's a description from one of my textbooks showing how exactly amino acids are absorbed. I had a much better textbook with an image showing means of absorption for each individual EAA, but I'm on break and don't have access to it. You can PM me in a week if you're still interested.

I basically said this in a post a page back, nice pics though . I believe researchers recently found transport proteins for very short peptides, though.

edit: didnt read it all, I guess you said that too.

[grngoloco]

Mainly asking about the importance of taking aminos individually and separately .... how important is it?

[mr.cooper69]

Mainly asking about the importance of taking aminos individually and separately .... how important is it?

Not even remotely important.

[grngoloco]

Been on the go all day,, haven't had time to look into the responses I've gotten,, but I will

[grngoloco]

Not even remotely important.

Why do my arginine and glutamine bottles say to take on empty stomach?

[bigdavid]

lol cooper I think we used that same book for one of my nutrition classes

[mr.cooper69]

Why do my arginine and glutamine bottles say to take on empty stomach?

Because they think free form arginine/glutamine will hit the blood faster without other foods, which is correct. Unfortunately, arginine does not elevate NO nor provide any other worthwhile benefit, and glutamine has failed to improve recovery time and time again. Neither should be your concern. Now you can take BCAAs on an empty stomach to spike blood leucine and maximize MPS.

lol cooper I think we used that same book for one of my nutrition classes

That's one of my mcat prep books so I don't think so .

[bigdavid]

That's one of my mcat prep books so I don't think so .

Well that's why then. I did princeton review also lol..but it looks o so similar to a nutrition book of mine..

[grngoloco]

Because they think free form arginine/glutamine will hit the blood faster without other foods, which is correct. Unfortunately, arginine does not elevate NO nor provide any other worthwhile benefit, and glutamine has failed to improve recovery time and time again. Neither should be your concern. Now you can take BCAAs on an empty stomach to spike blood leucine and maximize MPS.

That's one of my mcat prep books so I don't think so .

I never worried about NO with arginine,,, I was under the impression if taken at very high doses in a 2:1 ratio with ornithine it will stimulate gh release