amino receptors

[grngoloco]

Until now all you have done is regurgitate something you think you recall you think you read or someone told you.

Walk the talk - where is your research to back this up with the "entire studies and books written about them?" Right now all you have brought is your opinion as well.

I don't know much about amino acid receptors,, which is why I proposed this thread... but I do know they exist ...
http://m.pnas.org/content/90/20/9576.short

[grngoloco]

http://scholar.google.com/scholar?q=...ed=0CBoQgQMwAA

[grngoloco]

http://www.getbig.com/articles/protein.htm

[grngoloco]

http://www.innvista.com/health/nutri...mino/intro.htm

[grngoloco]

"Amino Acid Receptor Research"
By Benjamin F. Paley

[grngoloco]

All these articles mention taking on an empty stomach to prevent competition.... I want to know more about this.... not looking to pick some sort of retarded online fight with people ... lmao!!

[David Dunn]

It appears that this receptor you are talking about is post first pass through the liver and has absolutely nothing to do with how you take them - empty stomach or not - as they don't compete for absoption in your digestion aside from the fact that BCAA are predigested and are absorbed without having to go through the digestion process that protein powders or whole foods do. The receptor issue is a physiological and nuerological issue and not dependent upon the timing or state of your stomach at the time of consumption but rather what happens with them after first pass liver processing.

Based on my cursory review of some of that literature it is JMHO

[grngoloco]

It appears that this receptor you are talking about is post first pass through the liver and has absolutely nothing to do with how you take them - empty stomach or not - as they don't compete for absoption in your digestion aside from the fact that BCAA are predigested and are absorbed without having to go through the digestion process that protein powders or whole foods do. The receptor issue is a physiological and nuerological isse and not dependent upon the timing or state of your stomach at the time of consumption but rather what happens with them after first pass liver processing.

Based on my cursory review of some of that literature it is JMHO

For argument sake,, why does my glutamine and arginine both say to take on an empty stomach

[bigdavid]

For argument sake,, why does my glutamine and arginine both say to take on an empty stomach

He is saying the "receptor" issue has to do with the aminos AFTER they enter the body. What you are talking about is competition for entry through the intestinal lining BEFORE the aminos enter the body.

[grngoloco]

He is saying the "receptor" issue has to do with the aminos AFTER they enter the body. What you are talking about is competition for entry through the intestinal lining BEFORE the aminos enter the body.

I'm talking about wanting to get the most bang for my buck .... lol... like I said,, if I already knew all about receptors, why would I post a log asking about them? Haha!?

[bigdavid]

I'm talking about wanting to get the most bang for my buck .... lol... like I said,, if I already knew all about receptors, why would I post a log asking about them? Haha!?

I think there may be a semantics issue here. You are talking about competition for transport proteins on the lining of the intestine I think you are calling them receptors, though.

[grngoloco]

Crystaline free form amino acids do not need to be digested,, so where does that play into the pre and post digestion competition for absorption??

[grngoloco]

I think there may be a semantics issue here. You are talking about competition for transport proteins on the lining of the intestine I think you are calling them receptors, though.

I think you may be right about that,,, like I said early in the thread,, I wasn't sure the term "receptor" was the correct term

[grngoloco]

I think there may be a semantics issue here. You are talking about competition for transport proteins on the lining of the intestine I think you are calling them receptors, though.

With that in mind,,, how important is the necessity to take aminos individually on an empty stomach

[bigdavid]

Crystaline free form amino acids do not need to be digested,, so where does that play into the pre and post digestion competition for absorption??

Some amino acids are charged thus they cannot just diffuse through the intestinal cells to enter the body they have to be transported across. Since there is a limited number of transporters there will be competition if you take them with a whole protein source because the individual amino acids that are being broken apart from the whole protein source will be competing for use of these transporters. The process of "digestion" where you break apart the protein into individual amino acids with stomach acid and then with enzymes secreted from the pancreas or on the intestinal cell lining is a different process that happens before they are absorbed. The competition is not with digestion, since free form AA's are already in their broken down form. The competition is in the use of the transport proteins to get the amino acids in the body.

[bigdavid]

So the thought is take the free form aminos on an empty stomach to avoid competition from the aminos that will come from the whole protein source.

[grngoloco]

So the thought is take the free form aminos on an empty stomach to avoid competition from the aminos that will come from the whole protein source.

What about ff aminos competing with each other,, even when taken on an empty stomach,, that's my main concern and the crux of what I was originally trying to get to

[David Dunn]

Crystaline free form amino acids do not need to be digested,, so where does that play into the pre and post digestion competition for absorption??

You are over analyzing this. Predigested BCAA are quickly absorbed because they do not need to be digested. They then go through the liver and then the "receptors" come into play. The receptor has nothing to do with digestion or absorption. It is after absorption and processed through the liver that receptors are an issue. This is the same process for protein powdersa and whole for protein except the are slower digested in the digestive tract before they go through the same process in the liver.

Now greater amounts of various forms or proteins, EAA or BCAA consumed may influence the amount available to pass through the liver increasing what is available for receptors after passing through the liver.

[bigdavid]

If you are taking a limited dose of more than one amino there shouldnt be an issue. It is not like you are taking over 30 grams of ff AAs

[grngoloco]

You are over analyzing this. Predigested BCAA are quickly absorbed because they do not need to be digested. They then go through the liver and then the "receptors" come into play. The receptor has nothing to do with digestion or absorption. It is after absorption and processed through the liver that receptors are an issue. This is the same process for protein powdersa and whole for protein except the are slower digested in the digestive tract before they go through the same process in the liver.

Now greater amounts of various forms or proteins, EAA or BCAA consumed may influence the amount available to pass through the liver increasing what is available for receptors after passing through the liver.

Ok,, it is my understanding that bcaa's do not act the same way upon ingestion as, let's say, arginine, ornithine or glutamine