Based on the ingredients, it does not effect the thyroid hormones to have a negative effect.
Listed are:
Caffeine- excessive caffeine consumption can have negative effects on the thyroid, but with an average dose of 100-200mg in a day you should be fine.
DL-Phenylalanine(DLPA)- Is more of an appetite suppressant and mood booster. It is used by the brain to boost norepinephrine and is a precursor to tyrosine. With this being a precursor to tyrosine, it may have a benefit to your thyroid to help boost levels, especially if low, but this is not a direct T3 stimulation.
Beta-Phenylethylamine HCI (PEA HCI)- this can provide a boost to metabolism as well as mood but does not directly boost thyroid hormones. This also helps trigger the release of dopamine, so be careful not to take with anti-depressants.
Guaranine- is used to boost energy.
Griffonia Simplicifolia- is a precursor to 5-HTP and will have a positive effect on Mood and promote Relaxation. In higher doses it may help promote weight loss and appetite suppression
1-METIQ- neuroprotective factors along with positive effects on mood and weight loss, and really gets you focused.
Based on the ingredients this is a very solid profile and covers all aspects relating to mood, energy, and focus.