Brassinosteroid

  1. Pro Virili Parte
    JudoJosh's Avatar
    Join Date
    Nov 2008
    Age
    30
    Posts
    9,081
    Rep Power
    2849704
    Level
    81
    Lv. Percent
    72.56%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Brassinosteroid


    Looks pretty promising...

    Anabolic effect of plant brassinosteroid.

    Abstract

    Brassinosteroids are plant-derived polyhydroxylated derivatives of 5a-cholestane, structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids, with no known function in mammals. 28-Homobrassinolide (HB), a steroidal lactone with potent plant growth-promoting property, stimulated protein synthesis and inhibited protein degradation in L6 rat skeletal muscle cells (EC(50) 4 M) mediated in part by PI3K/Akt signaling pathway. Oral administration of HB (20 or 60 mg/kg/d for 24 d) to healthy rats fed normal diet (protein content 23.9%) increased food intake, body weight gain, lean body mass, and gastrocnemius muscle mass as compared with vehicle-treated controls. The effect of HB administration increased slightly in animals fed a high-protein diet (protein content 39.4%). Both oral (up to 60 mg/kg) and subcutaneous (up to 4 mg/kg) administration of HB showed low androgenic activity when tested in the Hershberger assay. Moreover, HB showed no direct binding to the androgen receptor in vitro. HB treatment was also associated with an improved physical fitness of untrained healthy rats, as evident from a 6.7% increase in lower extremity strength, measured by grip test. In the gastrocnemius muscle of castrated animals, HB treatment significantly increased the number of type IIa and IIb fibers and the cross-sectional area of type I and type IIa fibers. These findings suggest that oral application of HB triggers selective anabolic response with minimal or no androgenic side-effects and begin to elucidate the putative cellular targets for plant brassinosteroids in mammals.-Esposito, D., Komarnytsky, S., Shapses, S., Raskin, I. Anabolic effect of plant brassinosteroid.

    PMID: 21746867
    "The only good is knowledge and the only evil is ignorance." - Socrates

  2. PESCIENCE.com
    nattydisaster's Avatar
    Stats
    6'0"  0 lbs.
    Join Date
    Mar 2008
    Posts
    10,390
    Rep Power
    3952601
    Level
    85
    Lv. Percent
    60.96%
    Achievements Activity AuthorityActivity ProActivity VeteranPosting ProPosting Authority

    Pretty sure they are toxic
    HIGH VOLUME - Supreme Stim-Free Nitric Oxide Matrix
    SELECT Protein
    - Ultra-Premium Blend
    ALPHAMINE - Thermogenics...Redefined

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in