Did you hear the big news about Ursolic Acid?
- 09-16-2011, 04:16 PM
- 09-16-2011, 05:41 PM
09-16-2011, 07:07 PM
ETA Patrick? Compound is quite intriguing. Can you comment on its effects on fertility, as I have come across a couple studies demonstrating that it is potentially spermatoxic. If you could quell these concerns, I'd certainly buy a bottle or two .
09-16-2011, 07:28 PM
09-16-2011, 08:59 PM
09-16-2011, 10:05 PM
09-16-2011, 10:09 PM
the stuff about fertility is not clear. its not toxic in any way per se, but it could reduce sperm motility which if you are having a baby could be a concern. to put it into perspective its way less of a reproductive concern than any hormonal supp
09-16-2011, 11:01 PM
There was some concerns brought up around UA on another board if you cared to address them PA
Thoughts on Ursolic acid? (PA new product) - Page 3 - Mind And Muscle Forum
Specifically on DNA..
Full study here - Mind And Muscle Forumwhat do you make of this study? Not in vivo, I know, but does this raise any concerns in your mind about the safety of high dose ursolic acid...
Atherosclerosis. 2011 Jun 22. [Epub ahead of print]
Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo.
Messner B, Zeller I, Ploner C, Frotschnig S, Ringer T, Steinacher-Nigisch A, Ritsch A, Laufer G, Huck C, Bernhard D.
Cardiac Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria.
The plant derived triterpene ursolic acid (UA) has been intensively studied in the past; mainly as an anti-cancer compound and for its cardiovascular protective properties. Based on the controversy of reports suggesting anti-angiogenic and cytotoxic effects of UA on one side and cardiovascular and endothelial protective effects on the other side, we decided to assess UA effects on primary human endothelial cells in vitro and atherosclerotic plaque formation in vivo.
METHODS AND RESULTS:
Our in vitro analyses clearly show that UA inhibits endothelial proliferation and is a potent inducer of endothelial cell death. UA causes DNA-damage, followed by the activation of a P53-, BAK-, and caspase-dependent cell-death pathway. Oral application of UA in APO E knockout mice potently stimulated atherosclerotic plaque formation in vivo, which was correlated with decreased serum levels of the athero-protective cytokine IL-5.
Due the potent endothelial cell death inducing activity of UA, a systemic application of UA in the treatment of cardiovascular diseases seems unfavourable. UA as an anti-angiogenesis, anti-cancer and - locally applied - cardiovascular drug may be helpful. The DNA damaging activity of UA may however constitute a serious problem.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
also to add to the topic of UA it appears one apple peel is the equivalent to about 50mg's of UAUA also appears to have potent anti-proliferative effects and inhibits DNA replication which explains its utility for treating cancer but I am not sure if you want that under normal conditions...for example, what effect does this have on intestinal or epidermal cell turnover?
The other thing I find sort of odd about this stuff is that there are reams of in vitro studies, mainly with cancer cell lines and some in vivo animal studies but I can't find a single published study where UA was given to live humans for any reason...
I dont know if there are any actual safety concerns over UA, especially considering a apple peel contains 50mg and ursobolic only contains 150mg (about 3 apples) so I cant imagine there being much risk but I think it is still a valid point to bring up for discussionIsolation of ursolic acid from apple peels by high speed counter-current chromatography
Rosa T.S. Frighettoa, Rodolfo M. Welendorfb, Eduardo N. Nigrob, Nélson Frighettob, Antonio C. Sianic, ,
Cuticular waxes of four varieties of Malus domestica were investigated regarding their content of ursolic acid. Peels from Fuji, Gala, Smith and Granny Smith apples were extracted with chloroform, ethyl acetate and/or ethanol. The crude extracts were purified by high speed counter-current chromatography (HSCCC), by using mobile and stationary phases derived from the two-phase solvent system composed by n-hexane:ethyl acetate:methanol:water in the proportion of 10:5:2.5:1. The phase proportions and the relative distribution of ursolic acid between the two-phases were optimized by TLC and optical densitometry, by comparison with an authentic sample of ursolic acid. The amount of ursolic acid present in the extracts as well as the characterization of the isolated compound were made by high resolution gas chromatography coupled to mass spectrometry (GC–MS), 13C nuclear magnetic resonance (13C NMR), Infrared; and by comparing thin layer chromatography and flame ionization detection gas chromatography (GC–FID) patterns with the commercial sample. The average content of ursolic acid of 0.8 mg/cm2 in the peel (around 50 mg per medium sized fruit with a surface area of 50–70 cm2) was found in the Fuji and Smith varieties, whereas 0.5 mg/cm2 and 0.2 mg/cm2 were the amounts calculated for Granny Smith and Gala, respectively. The HSCCC technique was shown to be a good method to purify free ursolic acid from apple peels and could represent a new technological tool to be developed to exploit industrially this source of product.
Keywords: High speed counter-current chromatography (HSCCC); Malus domestica; Apple peel; Ursolic acid
"The only good is knowledge and the only evil is ignorance." - Socrates
09-17-2011, 09:25 AM
Bump for judo. Very interesting discussion going on here the product definitely has me interested.
Athletic Xtreme Team REPhttp://www.AthleticX.net/
AXHOLE BY NATURE
09-17-2011, 08:28 PM
09-17-2011, 10:23 PM
I liked formadrol personally as a "PCT" to natadrol. I really enjoyed the whole cycle. I can't say it was the UA in forma, I am sure it was a combination of alot of things in it, and probably just the fact that I'm a badass that really made it work... lol
As for this new stuff from PAT, it looks like it could do some great things by really dosing the UA. Can't wait to see some more info and logs on the stuff.
09-20-2011, 11:20 AM
Here is a study showing positive effects from UA regarding atherosclerosis
and then this on DNA
"As for the DNA-damage aspect... well... There is also an in-vitro study called "Protective effects of Ursolic acid and Luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells" which claims that UA can increase the rate of DNA repair & prevent oxidative DNA damage. Another in-vitro study, "Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells," claims that UA can prevent tert-butyl hydroperoxide-induced DNA damage. The abstract even goes as far as to state that this "may help explain the lower cancer incidence in human population with high dietary intakes of fruits and vegetables." There are a couple other studies which also claim to have observed a protective effect, or that UA can increase the rate of DNA repair. Anyway, I think the jury's still out... As far as I know, none of these effects have been looked for or observed in vivo, in living humans"
it reminds me of coffee/caffeine. one study says it is bad for health another study says its good. we may never know what coffee really does. but its not gonna stop me from drinking my coffee
09-20-2011, 11:53 AM
09-20-2011, 12:31 PM
If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
09-20-2011, 01:57 PM
Very interesting discussion in here. Love the knowledge being spread around.
09-20-2011, 02:02 PM
09-21-2011, 06:39 AM
09-21-2011, 08:17 AM
09-21-2011, 09:05 AM
09-21-2011, 01:19 PM
10-13-2011, 08:42 AM
10-13-2011, 08:57 AM
10-13-2011, 07:02 PM
10-13-2011, 07:17 PM
10-13-2011, 07:35 PM
LG Sciences, just to clarify things, can you please state what your point was for making this particular thread?
10-13-2011, 08:24 PM
10-13-2011, 08:46 PM
10-13-2011, 09:01 PM
10-13-2011, 10:47 PM
I was just curious as to why the thread was created in the manner that it was. I thought there was something else bigger to be stated in the thread, but it just seems like a jab at E-Pharm for utilizing this ingredient as a stand alone product. It's not a matter of me not liking LG or anything like that. I was just hoping for some clarification, as the statement of LG using ursolic acid in products is old news. Maybe LG was willing to disclose the extract or amount or ursolic acid...
10-13-2011, 10:57 PM
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