What would you do with FREE 300mg ALA caps?

[KtchnChmst]

So I placed an order for 240 R-ALA Caps, and as a mistake the site sent me 240, 300mg ALA Caps.......They actually sent the correct R-ALA caps immediately after I told them about the mistake, but they told me to just keep the ALA caps.

-Now what?

1) Take with "cheat" meals?......How much?
2) Take pre-bed?.......How much?
3) Save for a future PCT for the AntiOxidant/Liver Detox benefits?

[Rodja]

Save it for a future cycle.

[KtchnChmst]

Thanks brother.
Is it absolutely useless as a GDA?

[Whacked]

IMHO, ALA is crap as a GDA, or best utilized for it's anti-oxidant properties...both of which r-ALA is superior.

ALA was all the rage circa 7-8 years until people started getting fat (!) and figured out r-ALA was superior and actually somewhat beneficial as a GDA.

r-ALA is an excellent anti-oxidant and glutathione synthesis in the liver and therefore hepatoprotective (most notably used during hormone cycles).

That said, there are more vastly superior GDA's out there.

[Whacked]

From different board.....

Study site:
α-Lipoic Acid Inhibits Adipocyte Differentiation by Regulating Pro-adipogenic Transcription Factors via Mitogen-activated Protein Kinase Pathways

Pre-adipocytes? Are we really going between pre adipocytes all that frequently?

Now these sentences are likely why the entire study wasn't printed as it ain't so good! Not only via mechanism of ALA, but that they only looked at pre-adipocytes rather than insulin mediated effects on mature adipocytes which obviously aren't blocked.

Recent studies have demonstrated that LA facilitates glucose transport and utilization in fully differentiated adipocytes, as well as in animal models of diabetes (14–16). These insulin-like actions of LA were mainly mediated by activation of IR/Akt signaling pathway.
Considering that insulin stimulates adipogenesis, this study was undertaken to investigate whether LA promotes differentiation of pre-adipocytes to mature adipocytes.

So what is happening is LA is allowing mature fat cells to get bombed with glucose, but not baby ones.

And then there's the bomb!

' In our study, LA at lower concentrations (100 µM) promoted adipogenesis whereas at higher concentrations (250 and 500 µM)it was inhibitory'

If it's promoting it, it's making you FATTER!

Here is the full study.

-Lipoic Acid Inhibits Adipocyte Differentiation by Regulating Pro-adipogenic Transcription Factors via Mitogen-activated Protein Kinase Pathways*
Kyung-Joo Cho , Hae-Eun Moon , Hadi Moini , Lester Packer , Do-Young Yoon ¶ and An-Sik Chung ||

From the Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089, and ¶Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, South Korea

Received for publication, October 21, 2002 , and in revised form, June 17, 2003.

[KtchnChmst]

Perfect.....Thanks fellas.
Wasn't really stressin it since it was free, and I haven't used regular ALA since '05.....So I'll just save it for Liver Detox.

[nattydisaster]

From different board.....

Study site:
α-Lipoic Acid Inhibits Adipocyte Differentiation by Regulating Pro-adipogenic Transcription Factors via Mitogen-activated Protein Kinase Pathways

Pre-adipocytes? Are we really going between pre adipocytes all that frequently?

Now these sentences are likely why the entire study wasn't printed as it ain't so good! Not only via mechanism of ALA, but that they only looked at pre-adipocytes rather than insulin mediated effects on mature adipocytes which obviously aren't blocked.

Recent studies have demonstrated that LA facilitates glucose transport and utilization in fully differentiated adipocytes, as well as in animal models of diabetes (14–16). These insulin-like actions of LA were mainly mediated by activation of IR/Akt signaling pathway.
Considering that insulin stimulates adipogenesis, this study was undertaken to investigate whether LA promotes differentiation of pre-adipocytes to mature adipocytes.

So what is happening is LA is allowing mature fat cells to get bombed with glucose, but not baby ones.

And then there's the bomb!

' In our study, LA at lower concentrations (100 µM) promoted adipogenesis whereas at higher concentrations (250 and 500 µM)it was inhibitory'

If it's promoting it, it's making you FATTER!

Here is the full study.

-Lipoic Acid Inhibits Adipocyte Differentiation by Regulating Pro-adipogenic Transcription Factors via Mitogen-activated Protein Kinase Pathways*
Kyung-Joo Cho , Hae-Eun Moon , Hadi Moini , Lester Packer , Do-Young Yoon ¶ and An-Sik Chung ||

From the Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089, and ¶Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, South Korea

Received for publication, October 21, 2002 , and in revised form, June 17, 2003.

Good info