I'm not gonna pretend to know the answer...but do think before the 'all caps preWO/none off days' dosing became popular recently, people were dosing 4 caps thru the day w/meals and having good results with it....so I bet you could probably play with the dosing to fit your schedule...I mean dosing 5-6 (or even 4-5) caps 2-3x's a week, would probably only result in the ArA just taking a little bit longer to reach total muscle saturation, and then you wind up with a longer run (which wouldn't be bad, IMO)....or you could dose 5-6 caps 2-3x's/week, then perhaps 1-2 caps on off days with meals...just a thought...