Higenamine/Norcoclaurine [NATTYDISASTER, PLEASE TAKE A LOOK :D]

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  1. Quote Originally Posted by nattydisaster View Post
    We weren't kidding when we said it was an upgrade

    ACTUALLY, I THINK YOU WERE BEING TOO MODEST.


  2. Effects on Dopamine

    At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

    http://examine.com/supplements/Higenamine/

    Any concerns for depression on this stuff?

    Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  3. Quote Originally Posted by Whacked View Post
    Effects on Dopamine

    At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

    http://examine.com/supplements/Higenamine/

    Any concerns for depression on this stuff?

    Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
    Im on my off cycle of enhanced and i can say i felt depressed for 2 weeks and couldnt wait to get back on until I took focus xt.
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  4. Higenamine does not cross over into the CNS where neuronal cells are located. Therefore, it is physiologically impossible for it to cause depression unless injected directly into your brain
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES

  5. Quote Originally Posted by Sprinterguy4 View Post

    Im on my off cycle of enhanced and i can say i felt depressed for 2 weeks and couldnt wait to get back on until I took focus xt.
    Since focus xt ameliorated your "depression," the cause is simply stimulant withdrawal
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES

  6. Quote Originally Posted by Whacked View Post
    Effects on Dopamine

    At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

    http://examine.com/supplements/Higenamine/

    Any concerns for depression on this stuff?

    Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
    What should be bolded in the abstract is a concentration OF 20 MILLIMOLAR. So not only would you need to inject higenamine, but you'd need to inject a metric ton.
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES

  7. Quote Originally Posted by mr.cooper69 View Post

    Since focus xt ameliorated your "depression," the cause is simply stimulant withdrawal
    Caff-free FXT and yes thats probably what it was. I couldnt imagine how strong a cocaine withdrawal would be
  

  
 

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