Higenamine/Norcoclaurine [NATTYDISASTER, PLEASE TAKE A LOOK :D]

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  1. Quote Originally Posted by nattydisaster View Post
    Sounds like when I take it!

    Glad your caffeine free weekend was still full of sweat lol
    i cheated a little, lol. but way below my normal intake. i think next weekend i will just stick with at2 and no caffeine!!!
    WELL DONE IS BETTER THAN WELL SAID


  2. Very interesting. Thanks to all of you.
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  3. Quote Originally Posted by mr.cooper69 View Post
    I haven't, but I have reviewed the science. I really like MS btw.

    That said, I'm considering never saying anything about an ingredient used by PES again on these boards. Stop being so sensitive.

    As everyone said prior, if you are going to make a statement, just back it up with some opinion or information. It helps no one just saying this is better or that. Say whatever the hell you want, but at least say why.
    The Historic PES Legend

  4. Quote Originally Posted by nattydisaster View Post
    Sounds like when I take it!

    Glad your caffeine free weekend was still full of sweat lol
    Im starting to think I have really bad adrenal fatigue hahaha. How would at2 be for me? I know its a beta agonist but would it affect my adrenal glands? If so I have some clen on hand until they return to normal.
    "No citizen has a right to be an amateur in the matter of physical training...what a disgrace it is for a man to grow old without ever seeing the beauty and strength of which his body is capable." - Socrates

  5. Quote Originally Posted by oogaly_boogal View Post
    Im starting to think I have really bad adrenal fatigue hahaha. How would at2 be for me? I know its a beta agonist but would it affect my adrenal glands? If so I have some clen on hand until they return to normal.
    A beta agonist would not help adrenal fatigue lol. If you do suspect you have some acute adrenal fatigue, try something like Revamp. Same formula as the old Reset AD
    HIGH VOLUME - Supreme Stim-Free Nitric Oxide Matrix
    SELECT Protein
    - Ultra-Premium Blend
    ALPHAMINE - Thermogenics...Redefined

  6. Thanks, just ordered a bottle. I don't have all the symptoms, just tired all day. I don't have issues while working out and the such.
    "No citizen has a right to be an amateur in the matter of physical training...what a disgrace it is for a man to grow old without ever seeing the beauty and strength of which his body is capable." - Socrates

  7. I hear it works wonders on the adrenals after long stim use
    HIGH VOLUME - Supreme Stim-Free Nitric Oxide Matrix
    SELECT Protein
    - Ultra-Premium Blend
    ALPHAMINE - Thermogenics...Redefined

  8. I've used both versions of Alpha-T2, actually I started the newest version 2 days ago, took it as a preworkout aid and I was sweating more than I normally do with the first version, and by that I mean the first version had me drenched. THIS ONE IS BETTER.

  9. We weren't kidding when we said it was an upgrade
    HIGH VOLUME - Supreme Stim-Free Nitric Oxide Matrix
    SELECT Protein
    - Ultra-Premium Blend
    ALPHAMINE - Thermogenics...Redefined

  10. Quote Originally Posted by nattydisaster View Post
    A beta agonist would not help adrenal fatigue lol. If you do suspect you have some acute adrenal fatigue, try something like Revamp. Same formula as the old Reset AD
    That's great to know. Before I recommended AOR Adrenal, I actually looked for the Reset-AD quick. I had never heard of Revamp. Definitely a good idea for people running stims for long periods, and want to have some damage control for the withdrawals
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  11. Quote Originally Posted by nattydisaster View Post
    We weren't kidding when we said it was an upgrade

    ACTUALLY, I THINK YOU WERE BEING TOO MODEST.
    WELL DONE IS BETTER THAN WELL SAID

  12. Effects on Dopamine

    At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

    http://examine.com/supplements/Higenamine/

    Any concerns for depression on this stuff?

    Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  13. Quote Originally Posted by Whacked View Post
    Effects on Dopamine

    At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

    http://examine.com/supplements/Higenamine/

    Any concerns for depression on this stuff?

    Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
    Im on my off cycle of enhanced and i can say i felt depressed for 2 weeks and couldnt wait to get back on until I took focus xt.

  14. Higenamine does not cross over into the CNS where neuronal cells are located. Therefore, it is physiologically impossible for it to cause depression unless injected directly into your brain

  15. Quote Originally Posted by Sprinterguy4 View Post

    Im on my off cycle of enhanced and i can say i felt depressed for 2 weeks and couldnt wait to get back on until I took focus xt.
    Since focus xt ameliorated your "depression," the cause is simply stimulant withdrawal

  16. Quote Originally Posted by Whacked View Post
    Effects on Dopamine

    At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

    http://examine.com/supplements/Higenamine/

    Any concerns for depression on this stuff?

    Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
    What should be bolded in the abstract is a concentration OF 20 MILLIMOLAR. So not only would you need to inject higenamine, but you'd need to inject a metric ton.

  17. Quote Originally Posted by mr.cooper69 View Post

    Since focus xt ameliorated your "depression," the cause is simply stimulant withdrawal
    Caff-free FXT and yes thats probably what it was. I couldnt imagine how strong a cocaine withdrawal would be
  

  
 

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