Melatonin. Good or bad for testosterone.

[DerickVonD]

I've searched this site and on google about melatonin's effects on testosterone and some articles say it reduces test levels, some say it raises test levels and some say it doesn't have any real effect. I'd like to hear what your experience with melatonin is, whether or not it helped or harmed your workout. I took melatonin once and it seemed to help me fall right asleep, which is why I'm asking because if it won't effect my test level in a negative way I'm going to be using it maybe not often but on college night when I can't get to sleep.

[kanakafarian]

I've searched this site and on google about melatonin's effects on testosterone and some articles say it reduces test levels, some say it raises test levels and some say it doesn't have any real effect. I'd like to hear what your experience with melatonin is, whether or not it helped or harmed your workout. I took melatonin once and it seemed to help me fall right asleep, which is why I'm asking because if it won't effect my test level in a negative way I'm going to be using it maybe not often but on college night when I can't get to sleep.

Don't know if it raises or lowers test but I use it when I'm on cycle to help me get to sleep. I've never noticed anything negative while using it besides the vivid dreams.

[Markusrulezzz]

Are There Any Side-Effects?

According to one report, "10 percent of the users said the hormone did nothing for them, and another 10 percent complained of side effects such as nightmares, headaches, morning grogginess, mild depression, and low sex drive. In past studies, researchers have given people up to 600 to 3,000 times the usual doses - without causing any toxicity.

[StackedCop]

My doctor told me you can take 15-20gms easily without any side effects. I don't always put much faith in doctors though. Anyway, some times it helps me sleep other times it does nothing. As far as it's effect on test I would imagine the increase or decrease would be so minimal if anything at all... That's a complete guess just from my experience. I just think we would see more threads about this if it caused dudes to have limp d!ck...

[JudoJosh]

Libido levels aren't necessarily indicative of testosterone levels. Only way to know for sure is to get bloods done. I doubt it has much of any effect on them but I don't know for sure. Either way it isn't meant go be used every day anyway. I use it sparingly for better sleep not as a staple supplement.

[mr.cooper69]

I have 2 blood tests done from before using melatonin and 2 blood tests from during use. Granted, there are a ton of other factors, but my test has been up on the latest blood work.

[SonicSWOLE]

Breast Cancer Res Treat. 2002 Jan;71(1):37-45.

Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells.
Kiefer T, Ram PT, Yuan L, Hill SM.

Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Abstract
We have previously demonstrated that the pineal hormone, melatonin, can inhibit the growth of estrogen receptor-alpha (ERalpha)-positive breast cancer cells and suppress ERalpha gene transcription. To investigate the relationship between the estrogen response pathway and melatonin's growth inhibition, ERalpha-positive MCF-7 human breast cancer cells were transiently transfected with an estrogen response element (ERE) luciferase reporter construct and then treated with melatonin (10(-9)-10(-6) M) for 30 min followed by 10(-9) M 17-beta-estradiol (E2) or treated with each compound alone. Melatonin pre-treatment significantly reduced E2-induced ERalpha transactivation and ERalpha-ERE binding activity. We also conducted experiments to determine if melatonin modulates cAMP levels in MCF-7 cells. Melatonin inhibited the forskolin-induced and E2-induced elevation of cAMP levels by 57 and 45%, respectively. These data indicate that melatonin can act as a biological modifier to affect ERalpha transcriptional activity by regulating signal transduction pathways which impinge on the ERalpha and by altering E2-mediated ERalpha transactivation and ERalpha DNA binding activity.

PMID: 11859872 [PubMed - indexed for MEDLINE]

[SonicSWOLE]

I would include it in every hormonal cycle (not PCT), for it's properties stated above. Plus the fact that it may improve sleep,that is where the money is. Sleep=growth. It is a hormonal, however, so treat it like one and cycle off.

[DerickVonD]

I would include it in every hormonal cycle (not PCT), for it's properties stated above. Plus the fact that it may improve sleep,that is where the money is. Sleep=growth. It is a hormonal, however, so treat it like one and cycle off.

When would you suggest cycling it? I've never taken anything I had to cycle.

[bioman]

I've used it at high doses(20-30mgs) for long periods of time with no negative sides that I have ever noticed...libido, depression etc. No labs to confirm but everything I've read mostly indicates it is a decent hormone and great antioxidant with anti-cancer properties. LEF.org speaks highly of it, but then they sell it as well.

[StackedCop]

When would you suggest cycling it? I've never taken anything I had to cycle.

I only take it when I feel like I'm gonna have a hard time sleeping. So Maybe 2-3 nights a weeks. I would use it on a day to day bases.

Judo what you think?

[kanakafarian]

I only take it when I feel like I'm gonna have a hard time sleeping. So Maybe 2-3 nights a weeks. I would use it on a day to day bases.

Judo what you think?

This is exactly what I do too, but I throw in 200mg of Valerian for insurance. Me needs me sleep!

[StackedCop]

This is exactly what I do too, but I throw in 200mg of Valerian for insurance. Me needs me sleep!

If you want a good buzz throw some kava kava and l dopa in with that little stack makes me feel crazy relaxed

[SonicSWOLE]

When would you suggest cycling it? I've never taken anything I had to cycle.

Doesn't have to be a planned out "cycle" so to speak. Just give yourself time off of it, or use it only when you feel needed. As with anything....keep it simple.

[DerickVonD]

Doesn't have to be a planned out "cycle" so to speak. Just give yourself time off of it, or use it only when you feel needed. As with anything....keep it simple.

I was thinking 2-3 times a week is that too much?

[StackedCop]

I was thinking 2-3 times a week is that too much?

That's how i do it but if I don't need it I will skip and some times not use for a week or 2

[JudoJosh]

If you want a good buzz throw some kava kava and l dopa in with that little stack makes me feel crazy relaxed

What is this Kava Kava you speak of? I have horrible sleep patterns so I am always on the hunt for something to help me get a more restful nights sleep

I recently bought this set



Supposedly it plays certain wavelength to stimulate certain parts of your mind which helps you achieve various things. I was listening to the Alpha CD earlier today while in the tub with some Epsom salt and within 2 minutes I was out of it straight dreaming, I mean some vivid ass day dreaming that I completely forgot I was in the tub. Gonna Delta CD tonight to see if it helps me sleep better

[Aleksandar37]

Breast Cancer Res Treat. 2002 Jan;71(1):37-45.

Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells.
Kiefer T, Ram PT, Yuan L, Hill SM.

Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Abstract
We have previously demonstrated that the pineal hormone, melatonin, can inhibit the growth of estrogen receptor-alpha (ERalpha)-positive breast cancer cells and suppress ERalpha gene transcription. To investigate the relationship between the estrogen response pathway and melatonin's growth inhibition, ERalpha-positive MCF-7 human breast cancer cells were transiently transfected with an estrogen response element (ERE) luciferase reporter construct and then treated with melatonin (10(-9)-10(-6) M) for 30 min followed by 10(-9) M 17-beta-estradiol (E2) or treated with each compound alone. Melatonin pre-treatment significantly reduced E2-induced ERalpha transactivation and ERalpha-ERE binding activity. We also conducted experiments to determine if melatonin modulates cAMP levels in MCF-7 cells. Melatonin inhibited the forskolin-induced and E2-induced elevation of cAMP levels by 57 and 45%, respectively. These data indicate that melatonin can act as a biological modifier to affect ERalpha transcriptional activity by regulating signal transduction pathways which impinge on the ERalpha and by altering E2-mediated ERalpha transactivation and ERalpha DNA binding activity.

PMID: 11859872 [PubMed - indexed for MEDLINE]

I wouldn't base your whole opinion on this because it is one study, was in cell cultures, and cancer cells don't always react the way that others do. Seems worth looking further into though.

Looking through pubmed, melatonin does seem to interact with test and estro, but to what extent doesn't seem to be very conclusive. I wouldn't personally make a habit out of it, but a few days a week or when you are having problems sleeping is a good idea. Something that will give you good, natural sleep unlike some sleep meds will only help your health and test.

[swollen87]

i take melatonin every night... 10 grams.. i never cycle off

my test levels are in the 800s

[StackedCop]

i take melatonin every night... 10 grams.. i never cycle off

my test levels are in the 800s

Holy ****! Mine come in 5mg tabs.. That's a lot of tabs and a pretty expensive habit.