- 03-02-2011, 01:25 AM
- 03-02-2011, 06:07 AM
03-02-2011, 07:12 AM
I've used both GPLC and Agmatine and both feel different to me. Agmatine is good stuff though. I like it at 1000mg a day the best. 500mg pre and 500mg post good pumps and recovery.
Never had the squirts from it either, just to show the other side of the coin.
Genomyx Protocol V2 and SNS bulk Agmatine caps would make an excellent stack.
03-03-2011, 12:33 PM
It's in quite a few products.
I'd try either Protocol, Maximize V2, or SNS Agmatine.
Works very well at producing phenomenal pumps and I never had ANY stomach issues with this one.
03-03-2011, 12:41 PM
Neurosci Res. 2005 Aug;52(4):387-92.
Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channels.
Askalany AR, Yamakura T, Petrenko AB, Kohno T, Sakimura K, Baba H.
Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Endogenous polyamines like spermine are known to have four distinct effects on recombinant N-methyl-d-aspartate (NMDA) receptor channels: voltage-dependent inhibition, glycine-dependent stimulation, glycine-independent stimulation and decreased affinity to the agonist (l-glutamate). These effects are highly dependent on the constituting epsilon subunits (epsilon1-epsilon4) of the recombinant NMDA receptor channels. Agmatine reportedly inhibits native NMDA receptor channels in cultured hippocampal neurons. In the present investigation, the effects of agmatine on the epsilon/zeta heteromeric NMDA receptor channels expressed in Xenopus laevis oocytes were examined using the two-electrode voltage clamp method. Agmatine inhibited the four epsilon/zeta (epsilon1/zeta1, epsilon2/zeta1, epsilon3/zeta1 and epsilon4/zeta1) channels with similar sensitivity (an IC50 value of about 300microM at -70mV). This effect was dependent on the membrane potential and was more pronounced at hyperpolarized membrane potentials (voltage-dependent inhibition). Agmatine did not exhibit other stimulatory (glycine-dependent and -independent effects) or inhibitory (decreased affinity to l-glutamate) effects. These properties are similar to the pharmacological profile of well-characterized NMDA receptor channel blockers like phencyclidine and ketamine. Thus, regarding the effects on the NMDA receptor channels, agmatine is not like other endogenous polyamines rather it acts as a channel blocker.
It does have some positive effects on GH and in some other areas- something to look into.....
Dirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals
03-07-2011, 01:17 PM
03-07-2011, 02:53 PM
03-07-2011, 07:48 PM
03-07-2011, 08:19 PM
When an omega male is born it's game over
03-07-2011, 08:25 PM
03-07-2011, 08:29 PM
03-07-2011, 08:31 PM
CELTIC LABS REP
03-07-2011, 09:16 PM
03-07-2011, 09:35 PM
03-07-2011, 10:04 PM
You guys are tempting me to try it, just curious if its worth the cost compared to what else i could get for the same price
CELTIC LABS REP
03-07-2011, 10:10 PM
03-07-2011, 10:15 PM
03-08-2011, 08:51 AM
03-08-2011, 03:47 PM
03-08-2011, 03:51 PM
03-08-2011, 04:33 PM
03-08-2011, 05:01 PM
03-08-2011, 10:31 PM
03-09-2011, 09:44 AM
I would create a little pre-workout ****tail
Citrulline Malate 3g
Creatine Nitrate 1000mg
03-09-2011, 11:46 AM
08-03-2011, 02:32 AM
i had no idea DAA shouldn't be used w/ agmatine? im using DAA now and i literally just bought some agmatine and was going to be using it tomorrow. glad i read the thread.
after stopping the DAA how long should i wait to use it?
08-03-2011, 10:11 AM
I enjoyed Amgatine, its got a tremendous amount of health benefits as well. I would try Focus XT/Agamtine or Protocol/Agmatine as mentioned.
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08-03-2011, 10:38 AM
MAN combines DAA and Amgatine in there formula. They are pretty smart people where supplements are concerned.
Like Huperzine A, Agmatine is also believed to be able to prevent the highly unlikely event of D-Aspartic Acid induced neuro-toxicity. In short, Agmatine is believed to do so by preventing over-excitation of NMDA receptors and reversing the levels of activation.
The important thing to distinguish here is that exogenous application of Agmatine and D-Aspartic acid work on different mechanisms for the NMDA receptor, so regardless of one being an antagonist and the other an agonist, they do not overlap. Exogenous D-aspartic acid application utilizes the R-type VGCCs and none of the others, while exogenous Agmatine is said to use the L-type VGCCs and shows no signs of inhibition of the R-type VGCCs. Exogenous application of Agmatine will enhance its regulatory role in the body so that in higher levels of NMDA receptor activation, it will inhibit the receptor from higher glutamate release (so over-excitation leading to potential neuro-toxicity) by inhibiting the receptor.
08-03-2011, 12:47 PM
08-03-2011, 01:29 PM
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