hey guys i know most are going to say fat loss a good diet etc.and yes i know a lot of people say no-2 stuff does not work.well i have used some in the past to help me look more ripped and veinny (sp).i have small veins and when taking no stuff they swell and look bigger or stick up more i like that.i workout to look like fitness models you know ripped and cutt to shreeds(sp).i have tried some no 2 stuff several sevral years ago some stuff from controlled labs that work pretty good and nitrix was ok.but i have been away for awhile so was wondering what was the latest and gratest new no2 products for muscularity and veins ripped etc.
Lit-Up/Free Test is an excellent choice in this department:
The stack increases NO2 and increases hydrogen sulfide levels as well from the SAM-e cycle stimulation and the inclusion of a large dose of NAC- here are some studies about the synergism of NO2 and H2S:
Biochem Biophys Res Commun. 1997 Aug 28;237(3):527-31.
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.
Hosoki R, Matsuki N, Kimura H.
Department of Chemical Pharmacology, Toho University Schol of Pharmaceutical Sciences, Chiba, Japan.
Abstract
Hydrogen sulfide (H2S), which is well known as a toxic gas, is produced endogenously in mammalian tissues from L-cysteine mainly by two pyridoxal-5'-phosphate-dependent enzymes, cystathionine beta-synthetase and cystathionine gamma-lyase. Recently, we showed that cystathionine beta-synthetase in the brain produces H2S, and that H2S facilitates the induction of hippocampal long-term potentiation by enhancing NMDA receptor activity. Here we show that mRNA for another H2S producing enzyme, cystathionine gamma-lyase, is expressed in the ileum, portal vein, and thoracic aorta. The ileum also expresses cystathionine beta-synthetase mRNA. These tissues produce H2S, and this production is blocked by cystathionine beta-synthetase and cystathionine gamma-lyase specific inhibitors. Although exogenously applied H2S alone relaxed these smooth muscles, much lower concentrations of H2S greatly enhanced the smooth muscle relaxation induced by NO in the thoracic aorta. These observations suggest that the endogenous H2S may regulate smooth muscle tone in synergy with NO.
Mol Neurobiol. 2002 Aug;26(1):13-9.
Hydrogen sulfide as a neuromodulator.
Kimura H.
National Institute of Neuroscience, Kodaira, Tokyo, Japan.
[email protected]
Abstract
Hydrogen sulfide (H2S) is a well-known toxic gas with the smell of rotten eggs. Since the first description of the toxicity of H2S in 1713, most studies about H2S have been devoted to its toxic effects. Recently, H2S has been proposed as a physiologically active messenger. Three groups discovered that the brain contains relatively high concentrations of endogenous H2S. This discovery accelerated the identification of an H2S-producing enzyme, cystathionine beta-synthase (CBS) in the brain. In addition to the well-known regulators for CBS, S-adenosyl-L-methionine (SAM) and pyridoxal-5'-phosphate, it was recently found that Ca2+/calmodulin-mediated pathways are involved in the regulation of CBS activity. H2S is produced in response to neuronal excitation, and alters hippocampal long-term potentiation (LTP), a synaptic model for memory. can also regulate the release of corticotropin-releasing hormone (CRH) from hypothalamus. Another H2S producing enzyme, cystathionine gamma-lyase (CSE), has been identified in smooth muscle, and H2S relaxes smooth muscle in synergy with nitric oxide (NO). Recent progress in the study of H2S as a novel neuromodulator/transmitter in the brain is briefly reviewed.
