Prolactin, Dopamine question regarding L-Dopa from Mucana Pruriens

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    Prolactin, Dopamine question regarding L-Dopa from Mucana Pruriens


    I am dabbling with Now Mucana Dopa, which is 800mg of mucana pruriens that is 15% standardized to 120mg of L-Dopa (for 2 pills). I am only on day #2 of it.

    I am hoping to get a libido boost from it, or to shorten my refractory period.

    I am also on 100-150mg of P-5-P. I take 1x 50mg during the day, and then 100mg before bed with 50mg zinc and 250mg magnesium.

    I don't expect the L-Dopa to "make" me aroused or anything and it probably won't. I know some reports from some guys are they are turned on easier. If that is a benefit...it doesn't happen short term at least

    I just wanted to get everyone's take on this. I have no clue what my current prolactin levels are. I am typically a pretty up beat person, good mood, cracking jokes all the time, etc... My libido hasn't felt up to par the last 4-5 years. I might have 1 or 2 good days in terms of erection quality and performance, but seems like after sex...even days after I just don't "have it" if that makes sense. I don't get turned on easily post sex (be it hours or sometimes 1-2 days). I know after an orgasm prolactin shoots through the roof and can stay there for an extended period of time, so that is why I am doing things right now to try and lower it naturally and raise dopamine...though lowering the prolactin itself might naturally raise dopamine.

    Had testosterone checked last year...it was normal.

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    I guess my other question is ... how long does it take to begin seeing any results from using L-Dopa for dopamine boosting properties or p-5-p for prolactin reduction?

    I am also on a bunch of other supplements like ginkgo biloba, garlic, multi vitamin, american ginseng, L-arginine (sometimes...though I heard this increases prolactin), fish oil
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    Sounds like your taking some of the 5 "G's" for big erections. Ginseng, garlic, ginkgo, ginger and green tea

    I've been taking the same exact bottle of Mucuna as you for a little over a month. I started taking 2 caps a day but found that I started getting hot flashes and insomnia so now I take 1 cap every other day. And I take 100mgs p-5-p the same. I can't really say I've noticed a huge difference in anything but I also think I dose pretty conservatively. Messing around with neurotransmitters makes me a little cautious.
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    Quote Originally Posted by broons View Post
    Sounds like your taking some of the 5 "G's" for big erections. Ginseng, garlic, ginkgo, ginger and green tea

    I've been taking the same exact bottle of Mucuna as you for a little over a month. I started taking 2 caps a day but found that I started getting hot flashes and insomnia so now I take 1 cap every other day. And I take 100mgs p-5-p the same. I can't really say I've noticed a huge difference in anything but I also think I dose pretty conservatively. Messing around with neurotransmitters makes me a little cautious.
    hehe...yep. I haven't taken ginger in a while though, and I drink green tea. Not too sure the 5 g's helps me a ton though.

    I felt a bit of the hot flash stuff a bit yesterday, not so much today though. I am sticking my mucana doses in the morning..so to not run into the insomnia thing.

    I haven't gotten off, let alone gotten much of a worthy erection since 5 days ago. So not too sure "if" I will experience more desire or spotaneous wood while on mucana + p-5-p.

    For the last month while on that combo...have you actively been having sex, etc.. to determine whether it helps with refractory or anything?

    I have this strange sense I am a bit desensitized down there since on this combo. I haven't tried to get off, but am kind of wondering what I will feel when I do. Just more of the same, or some kind of continuation or mild continuation of desire post orgasm.
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    Just a bump of this thread.
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    Ya I live with my girlfriend so I actively have sex 3-4 times a week. No noticeable difference in refractory time but like I said, I am probably dosing pretty conservatively. Try adding some Fadogia to the mix, it's one of the few herbs that actually has a pronounced effect on my libido and I like it quite a bit. Thinking of adding some good quality Maca to the mix as well at maybe 5 grams a day or so just to try it out.
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    do you have puffy nips? that a big sign of high prolactin.

    and its gonna take a while for you to see results as these are all herbs not medications.
    The difference between who you are and who you want to be is what you do.
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    Quote Originally Posted by rochabp View Post
    do you have puffy nips? that a big sign of high prolactin.

    and its gonna take a while for you to see results as these are all herbs not medications.
    no. I am a pretty slim guy, 170lbs 6 ft.

    Had a testosterone test done last year.

    here were my results

    Total Testosterone: 603 (range 250-1100)
    Free: 1.69 (range 1.5 to 2.2)
    % Free: 101.9 (range 35 - 155)
    FSH - 3.0 (range 1.3 - 19.3)
    Luteinizing Horm: 3.9 (range 2.1 - 10.9)
    Prolactin: 9.3 (range 2.6-13.1)
    Cortisol Type: fasting, Total: 14.6 (range for fasting is 6.7-22.6)
    So from a libido perspective...not to sure how much of a difference 3 versus 9.3 would be in prolactin.
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    Quote Originally Posted by dgosh View Post
    no. I am a pretty slim guy, 170lbs 6 ft.

    Had a testosterone test done last year.

    here were my results



    So from a libido perspective...not to sure how much of a difference 3 versus 9.3 would be in prolactin.
    Did you have your SHBG levels checked as well? I noticed that your total testosterone is well within normal range, but your free testosterone levels are actually on the very low side of normal......but your % of free is normal, so that alone raises some additional questions
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    Quote Originally Posted by rms80 View Post
    Did you have your SHBG levels checked as well? I noticed that your total testosterone is well within normal range, but your free testosterone levels are actually on the very low side of normal......but your % of free is normal, so that alone raises some additional questions
    interesting.

    Just read this site: labtestsonline[dot]org/understanding/analytes/shbg/test.html

    and it seems to match with what your saying. I did not have my SHBG levels checked.

    "if" my SHBG levels are low (I assume low here is bad, high is good?), what does one do to raise them? Or is it like HRT where they give you a shot or a patch?

    Honestly, I have never felt "right" about my age, cleanliness (no drugs, alcohol, tobacco), weight, fitness, etc... + the herbs/supps i ahve taken that are supposed to help with libido..and NOTHING ever seems to effect me. Now I kind of wonder if my SHBG are off and that might explain why nothing seems to help.

    On a side note. I know prolactin levels spike after ejaculation which often causes the loss of libido and detachment effects. More so with ejaculation after intercourse, versus masturbation. I have noticed more after intercourse my desire for more sex drops much quicker and seems to last longer then via masturbation.

    and for what its worth, I have gotten off only 4 times in the last 2 months...I feel like I should be a walking hard on lol , but no...FAR FAR from it.
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    no high SHGB is bad cuz more SHGB less free test you have since SHGB binds to test making it inactive and "not free"
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    Quote Originally Posted by rochabp View Post
    no high SHGB is bad cuz more SHGB less free test you have since SHGB binds to test making it inactive and "not free"
    this really has me thinking... how do I have such low free testosterone...yet my %free is huge

    Free: 1.69 (range 1.5 to 2.2)
    % Free: 101.9 (range 35 - 155)

    though that range of 1.5 to 2.2 seems SO small, so moving up a few decimal places must be a pretty big spike versus full points. 1.9 sounds like it could be dramatically different then 1.69. yes?

    I am really wondering about this SHGB now.
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    Quote Originally Posted by dgosh View Post
    interesting.

    Just read this site: labtestsonline[dot]org/understanding/analytes/shbg/test.html

    and it seems to match with what your saying. I did not have my SHBG levels checked.

    "if" my SHBG levels are low (I assume low here is bad, high is good?), what does one do to raise them? Or is it like HRT where they give you a shot or a patch?

    Honestly, I have never felt "right" about my age, cleanliness (no drugs, alcohol, tobacco), weight, fitness, etc... + the herbs/supps i ahve taken that are supposed to help with libido..and NOTHING ever seems to effect me. Now I kind of wonder if my SHBG are off and that might explain why nothing seems to help.

    On a side note. I know prolactin levels spike after ejaculation which often causes the loss of libido and detachment effects. More so with ejaculation after intercourse, versus masturbation. I have noticed more after intercourse my desire for more sex drops much quicker and seems to last longer then via masturbation.

    and for what its worth, I have gotten off only 4 times in the last 2 months...I feel like I should be a walking hard on lol , but no...FAR FAR from it.
    You got it backwards When SHBG levels are high, your total testosterone levels can be completely normal- but your free testosterone levels will be very low, because most of your availiable testosterone is bound to SHBG.
    Urtica Dioica (Nettle Root) has been shown in several studies to have the ability to bind SHBG:

    Planta Med. 1997 Dec;63(6):529-32.

    Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
    Schöttner M, Gansser D, Spiteller G.

    Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.

    Abstract
    Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).

    Z Naturforsch C. 1997 Nov-Dec;52(11-12):834-43.

    Interaction of lignans with human sex hormone binding globulin (SHBG).
    Schöttner M, Gansser D, Spiteller G.

    Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.

    Abstract
    Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.

    J Nat Prod. 1998 Jan;61(1):119-21.

    Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.
    Schöttner M, Spiteller G, Gansser D.

    Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.

    Abstract
    The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.


    I do think you are going about this the correct way- try the mucuna for a few more weeks- but up the dosage to about 250-500 mg of L-Dopa- the dosage you are using is a little low. If that doesn't help anything, d/c it and start on the nettle root. By eliminating potential causes one at a time, you can troubleshoot and get to the bottom of the issue by being systematic. Normally it is one or more of the following that is causing the issue: high PRL, low T (free), high SHBG, diet (lot of high-fat foods), stress, or lack of rest. That being said- I would definitely go to the doctor if the higher dose of L-Dopa or the nettle root doesn't work....
    Dirk Tanis, BA, MSci
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    So I shouldn't go get tested first regarding my SHBG?

    btw - when on Mucana, even at my low dose...I sometimes feel a bit foggy or tired. normal?

    You said

    Normally it is one or more of the following that is causing the issue: high PRL, low T (free), high SHBG, diet (lot of high-fat foods), stress, or lack of rest.

    Well, we know I have low free T (or low end of the normal scale), my diet probably has a bit too much high fat foods, stress is elevated (work 2 jobs, kids, etc...) and I avg about 5-6 hours of sleep per night...so take your pick I guess

    but even with all that, my energy is usually pretty high, I am typically in an upbeat mood, even with that sleep I function just fine.

    Should I discontinue my use of most of my supplements? I am also on a multi, fish oil, garlic, gingko biloba, p-5-p, ginseng (american), sometimes add in L-arginine, ginger caps. I am cutting these out now..but was taking 50mg zinc + 250mg magnesium with the p-5-p at night before bed, but was told I might be getting excess zinc/mag since my multi + my food should have plenty.

    Also, I don't currently exercise though I will be soon..but have heard squats can be pretty important for testosterone, etc...

    Quote Originally Posted by rms80 View Post
    You got it backwards When SHBG levels are high, your total testosterone levels can be completely normal- but your free testosterone levels will be very low, because most of your availiable testosterone is bound to SHBG.
    Urtica Dioica (Nettle Root) has been shown in several studies to have the ability to bind SHBG:

    I do think you are going about this the correct way- try the mucuna for a few more weeks- but up the dosage to about 250-500 mg of L-Dopa- the dosage you are using is a little low. If that doesn't help anything, d/c it and start on the nettle root. By eliminating potential causes one at a time, you can troubleshoot and get to the bottom of the issue by being systematic. Normally it is one or more of the following that is causing the issue: high PRL, low T (free), high SHBG, diet (lot of high-fat foods), stress, or lack of rest. That being said- I would definitely go to the doctor if the higher dose of L-Dopa or the nettle root doesn't work....
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    also...so i am looking to UNBIND my testosterone from SHBG in order to raise my free testosterone, right?
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    Quote Originally Posted by dgosh View Post
    also...so i am looking to UNBIND my testosterone from SHBG in order to raise my free testosterone, right?
    exactly
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    so its "Total Testosterone" considered "bound testosterone"?
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    Quote Originally Posted by dgosh View Post
    so its "Total Testosterone" considered "bound testosterone"?
    total test accounts for both free and bound (i think)
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    Quote Originally Posted by dgosh View Post
    So I shouldn't go get tested first regarding my SHBG?

    btw - when on Mucana, even at my low dose...I sometimes feel a bit foggy or tired. normal?

    You said




    Well, we know I have low free T (or low end of the normal scale), my diet probably has a bit too much high fat foods, stress is elevated (work 2 jobs, kids, etc...) and I avg about 5-6 hours of sleep per night...so take your pick I guess

    but even with all that, my energy is usually pretty high, I am typically in an upbeat mood, even with that sleep I function just fine.

    Should I discontinue my use of most of my supplements? I am also on a multi, fish oil, garlic, gingko biloba, p-5-p, ginseng (american), sometimes add in L-arginine, ginger caps. I am cutting these out now..but was taking 50mg zinc + 250mg magnesium with the p-5-p at night before bed, but was told I might be getting excess zinc/mag since my multi + my food should have plenty.

    Also, I don't currently exercise though I will be soon..but have heard squats can be pretty important for testosterone, etc...
    I would keep using the supps, but add in or take away additional products/compounds one at a time, so at least you know what is effecting you and how it is effecting you.

    As far as the mucuna making you feel foggy or tired- do you take a lot of vitamin B-6?
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    Quote Originally Posted by rms80 View Post
    I would keep using the supps, but add in or take away additional products/compounds one at a time, so at least you know what is effecting you and how it is effecting you.

    As far as the mucuna making you feel foggy or tired- do you take a lot of vitamin B-6?
    whatever is in my multi..but I have been on 50-150mg/day of P-5-P which my understanding is the active piece of B6.

    I have also heard NOT to take p-5-p or B6 WITH mucana..they can counter act each other. I do take Mucana with drinking 1-2 cups of green tea.

    I am stopping the additional zinc/magnesium.

    regarding the supps...i have felt this way about my libido and erections for the last 5 or so years, but I do feel its getting a bit worse...and I have been on and off supps for several years "trying" different herbal things. It started with gingko biloba, ginseng, etc.. years ago and never felt much. Even tried Maca (like 2-3g per day) last year...nothing. Just seems like anything I throw at this problem falls on the floor. I have taken a "supplement" which mimicked the effects of viagra and definitely worked from an erection standpoint, but not something I was happy to take..but it definitely worked and lasted 36 hours or so. It was called Sexual Surge but I think its discontinued now. another one I have heard of is called Black magic, but again these are for erections..not libido.

    though one can associated getting an erection to begin with, with having a good libido. if desire isn't there, you most likely won't get hard even with enhancing drugs.
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    I thought this was worth posting, found on another forum about Nettle Root and SHBG

    * The most common reason why either E2 is high, or SHBG is high, or both E2 and SHBG are both too high, before commencing any hormone modulation therapy, is because there isn't enough cortisol floating around to downregulate T metabolism adequately (usually because of age-related-hormonal-decline of our cortisol production line), so the body has to take evasive action to reduce T metabolism. It does this either by:
    a) converting some of the available T into E2, because E2 downregulates T metabolism very strongly
    or:
    b) upregulating SHBG, because SHBG binds to T and effectively takes it out-of-service.

    * When our body cranks E2 to downregulate T metabolism, the high E2 wreaks havoc with our neurotransmitter balance, in ways which ruin our erection performance. Our body produces optimum neurotransmitter balance when it synthesizes optimum amounts of cortisol via pregnenolone. HC supplementation does not restore our neurotransmitters.

    * Increasing cortisol downregulates our T metabolism, which reverses any previous E2 and / or SHBG excesses which our body implemented due to too low cortisol.

    *** While you probably think that you don't want your testosterone metabolism downregulated at all, if you don't use cortisol to do it, then your body will either:
    a) synthesize E2 out of your T and then your body will use the E2 to downregulate your testosterone metabolism.
    or:
    b) crank your SHBG to downregulate your testosterone metabolism.

    *** You cannot run away from downregulating your T. It must be done. And you must use cortisol to do it not E2 and not SHBG. Hence you may need your cortisol boosted to achieve this.

    *** Males who think that they can "beat the system" by operating at low cortisol and taking arimidex to suppress E2, or taking nettle root extract to suppress SHBG, are doing this based on insufficient knowledge of hormones, because too low cortisol means too low pregnenolone, which means too low neurotransmitters. Having too low neurotransmitters means the brain cannot coordinate the larger volume of messages resulting from increased overall metabolism, which includes the increased volume of repair messages triggered by higher T metabolism.
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    Quote Originally Posted by rms80 View Post
    Did you have your SHBG levels checked as well? I noticed that your total testosterone is well within normal range, but your free testosterone levels are actually on the very low side of normal......but your % of free is normal, so that alone raises some additional questions
    had another guy on a forum say regarding the % free, since he thinks I have a typo somewhere.

    You can't have a percentage over 100% Regardless, I'm sure your doctor would agree that your numbers are great
    I am going off what i typed up last year, so I will have to go back to the paperwork and verify what I wrote down is correct, and include the units of measurement to be sure.
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    nettle root to slow down the binding of free test? ye?
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    Quote Originally Posted by AntonG42O View Post
    nettle root to slow down the binding of free test? ye?
    well...based on the last comment I posted from another thread...sounds like my % free test CAN'T be over 100, and that I either had a typo or something. Will have to find the original paperwork and determine.

    but based on that comment, my blood panel looked good so the unbinding wouldn't be necessary.
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    i mean thats just one person's opinion. look up good test ranges and compare yours. many times a long refractory period CAN be improved with more free test.
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    Would NOW Stinging Nettle Root Extract be sufficient?

    nowfoods[dot]com/Products/ProductsbyCategory/Category/M003249.htm?cat=Herbs%20%26%20 Mushrooms ?
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    subbed for some reading tomorrow
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    Quote Originally Posted by dgosh View Post
    Would NOW Stinging Nettle Root Extract be sufficient?

    nowfoods[dot]com/Products/ProductsbyCategory/Category/M003249.htm?cat=Herbs%20%26%20 Mushrooms ?
    from what ive been reading, Divanex is better. its a more standardized extract but also costs more. i was going to try the NOW foods myself to see if it does anything first.
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    Quote Originally Posted by dgosh View Post


    Well, we know I have low free T (or low end of the normal scale), my diet probably has a bit too much high fat foods, stress is elevated (work 2 jobs, kids, etc...) and I avg about 5-6 hours of sleep per night...so take your pick I guess
    A high fat diet will not negativly affect your test in anyway man. Fat is numero uno dude for test
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    has anyone ever tried Damiana or "Turnera diffusa"
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    I can tell you L-Dopa (Mucuna extract) helps my libido. I do feel tired sometimes after I dose it, but it doesn't last that long. I also spread out my doses with 4-5hour intervals since L-Dopa has a short half life. I am on X-Tren, that is known to kill libido, and my libido is still intact to a degree thanks to the L-Dopa. (Dosing it at 300mg/day + Cycle Assist that contains Quercetin)

    You might also wanna look into these:
    EGCG (from Green Tea extract) acts as a natural decarboxylase inhibitor which helps prevent excessive levels of Dopamine from building up in the body rather than the brain.

    Quercetin acts as a natural catechol-O-methyl transferase (COMT) inhibitor that improves L-DOPA's conversion into Dopamine in the brain and helps prevent Dopamine breakdown.


    Just thought I'd share my experiences with L-Dopa.

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    Quote Originally Posted by ConcreteConny View Post
    I can tell you L-Dopa (Mucuna extract) helps my libido. I do feel tired sometimes after I dose it, but it doesn't last that long. I also spread out my doses with 4-5hour intervals since L-Dopa has a short half life. I am on X-Tren, that is known to kill libido, and my libido is still intact to a degree thanks to the L-Dopa. (Dosing it at 300mg/day + Cycle Assist that contains Quercetin)

    You might also wanna look into these:
    EGCG (from Green Tea extract) acts as a natural decarboxylase inhibitor which helps prevent excessive levels of Dopamine from building up in the body rather than the brain.

    Quercetin acts as a natural catechol-O-methyl transferase (COMT) inhibitor that improves L-DOPA's conversion into Dopamine in the brain and helps prevent Dopamine breakdown.


    Just thought I'd share my experiences with L-Dopa.

    //CC
    Thanks.

    I drink probably 2-4 cups of green tea each day. I am now (as of yesterday) currently taking 4 Mucana pills each day, which translates into 1600mg of Mucana Pruriens which equats to 240mg of L-Dopa.

    For 1 week I was on just 2 pills, or 800mg / 120mg L-Dopa

    I am just at a breaking point..just not sure what my next step should be. Seems like I am "ripe", IMHO, to be experiencing a great sex life and good libido.

    I know stress is a killer...and as much responsibility I have in my life, I always feel like I handle my stress just fine. I don't get anxious, don't panic, I tend to always be calm even in moments of disarray, but I admit I do overthink my libido issues which I am sure doesn't help..but I am convinced "something" is going on physically or chemically with me that is not letting my potential out. I don't truly believe its just sleep and stress as some people put it. There are plenty of guys out there who probably run on 5 hours of sleep a night, drink tons of alcohol, smoke weed and tobacco, and eat fast food yet they are popping wood all the time and have short refractory periods.
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    Quote Originally Posted by ConcreteConny View Post
    I can tell you L-Dopa (Mucuna extract) helps my libido. I do feel tired sometimes after I dose it, but it doesn't last that long. I also spread out my doses with 4-5hour intervals since L-Dopa has a short half life. I am on X-Tren, that is known to kill libido, and my libido is still intact to a degree thanks to the L-Dopa. (Dosing it at 300mg/day + Cycle Assist that contains Quercetin)

    You might also wanna look into these:
    EGCG (from Green Tea extract) acts as a natural decarboxylase inhibitor which helps prevent excessive levels of Dopamine from building up in the body rather than the brain.

    Quercetin acts as a natural catechol-O-methyl transferase (COMT) inhibitor that improves L-DOPA's conversion into Dopamine in the brain and helps prevent Dopamine breakdown.


    Just thought I'd share my experiences with L-Dopa.

    //CC
    good looking out CC
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    Glad I could be of help to some extent

    dgosh: maybe up the Mucuna to 5 caps spread out evenly throughout the day? And maybe look into Quercetin..

    If that doesn't help, the foundation of the problem might be related to other factors.

    //CC
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    Quote Originally Posted by dgosh View Post
    whatever is in my multi..but I have been on 50-150mg/day of P-5-P which my understanding is the active piece of B6.

    I have also heard NOT to take p-5-p or B6 WITH mucana..they can counter act each other. I do take Mucana with drinking 1-2 cups of green tea.

    I am stopping the additional zinc/magnesium.

    regarding the supps...i have felt this way about my libido and erections for the last 5 or so years, but I do feel its getting a bit worse...and I have been on and off supps for several years "trying" different herbal things. It started with gingko biloba, ginseng, etc.. years ago and never felt much. Even tried Maca (like 2-3g per day) last year...nothing. Just seems like anything I throw at this problem falls on the floor. I have taken a "supplement" which mimicked the effects of viagra and definitely worked from an erection standpoint, but not something I was happy to take..but it definitely worked and lasted 36 hours or so. It was called Sexual Surge but I think its discontinued now. another one I have heard of is called Black magic, but again these are for erections..not libido.

    though one can associated getting an erection to begin with, with having a good libido. if desire isn't there, you most likely won't get hard even with enhancing drugs.
    I would take some low dose B-6 (2-5 mg/day) with L-Dopa- B-6 can become depleted if you don't take enough. However, doses over 10 mg/day can increase DDC (dopa decarboxylase) levels substantially, meaning that the L-Dopa will be converted to dopamine much quicker peripherally. You need L-Dopa to be intact so it can cross the BBB- dopamine has a very hard time crossing the barrier.....
    Dirk Tanis, BA, MSci
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    I wanted to give this thread a bump.

    Thanks for all the responses.

    I am also looking into Maca now. I have taken NOW Maca previously but didn't experience any form of results from it.

    however, those were capsules and I was getting close to 5g/day with those.

    Someone recommended getting the bulk powder, and they recommend Life-Flo Maca gold.

    Any suggestions?
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    Quote Originally Posted by rms80 View Post
    I would take some low dose B-6 (2-5 mg/day) with L-Dopa- B-6 can become depleted if you don't take enough. However, doses over 10 mg/day can increase DDC (dopa decarboxylase) levels substantially, meaning that the L-Dopa will be converted to dopamine much quicker peripherally. You need L-Dopa to be intact so it can cross the BBB- dopamine has a very hard time crossing the barrier.....
    not sure how i was going to tie this in here but p5p also lowers levels of tyrosine.... a key neurotransmitter so when you are tweaking with the body often times like we do(lets face it we are all our own guinnea pigs ) you need to consider all things....

    If you do take L-Tyrosine/Phenylalanine regularly because you need a little boost, it is recommended that you count the number of moles on your body (e.g. stomach area) and place this data in your notebook, and update at 1 to 3mth intervals. If you see your mole count go up, you should consider cooling it with the L-Tyrosine/Phenylalanine. Things that decrease Tyrosine, and therefore decrease Melanoma risk, are P5P, vitamin E, vitamin C, and low dose NAC (e.g. 50 to 300mg/day).
    extracted from this....http://www.beatcfsandfms.org/html/NaStrategy.html
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    Quote Originally Posted by JN230 View Post
    not sure how i was going to tie this in here but p5p also lowers levels of tyrosine.... a key neurotransmitter so when you are tweaking with the body often times like we do(lets face it we are all our own guinnea pigs ) you need to consider all things....

    If you do take L-Tyrosine/Phenylalanine regularly because you need a little boost, it is recommended that you count the number of moles on your body (e.g. stomach area) and place this data in your notebook, and update at 1 to 3mth intervals. If you see your mole count go up, you should consider cooling it with the L-Tyrosine/Phenylalanine. Things that decrease Tyrosine, and therefore decrease Melanoma risk, are P5P, vitamin E, vitamin C, and low dose NAC (e.g. 50 to 300mg/day).
    extracted from this....http://www.beatcfsandfms.org/html/NaStrategy.html
    Now that I didn't know Thanks for sharing!! Repped
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    Quote Originally Posted by JN230 View Post
    not sure how i was going to tie this in here but p5p also lowers levels of tyrosine.... a key neurotransmitter so when you are tweaking with the body often times like we do(lets face it we are all our own guinnea pigs ) you need to consider all things....

    If you do take L-Tyrosine/Phenylalanine regularly because you need a little boost, it is recommended that you count the number of moles on your body (e.g. stomach area) and place this data in your notebook, and update at 1 to 3mth intervals. If you see your mole count go up, you should consider cooling it with the L-Tyrosine/Phenylalanine. Things that decrease Tyrosine, and therefore decrease Melanoma risk, are P5P, vitamin E, vitamin C, and low dose NAC (e.g. 50 to 300mg/day).
    extracted from this....http://www.beatcfsandfms.org/html/NaStrategy.html
    Really good post- forskolin will do the same thing, at least to an extent, with the melanin. Have you ever tried melanotan? It will increase the number of moles you have exponentially- works great for tanning, but I don't think it is good long term....
    Dirk Tanis, BA, MSci
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    I am not messing with L-Tyrosine...so not sure if I should be considered about the above.
  

  
 

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