For those who didn't follow along in the Ecdysterone thread all I did was copy and paste.
Enjoy and long live !
EcdyMorph (99% 20-hydroxyecdysone) is extracted from the herbaceous perennial plant Rhaponticum Carthamoides. The same plant source used in human and animal studies . Most ecdysterone products sold in the market today use an extract derived from Cyanotis Vaga. This is a much cheaper extract and is usually only standardized to 40-70% 20-Hydroxecdysone.
EcdyMorph is produced using an extensive series of procedures to reach a purity of 99% 20-hydroxyecdysone. The final step in the process is super critical CO² extraction. This process creates material in a crystalline form. This formation of crystals differentiates EcdyMorph from other ecdysterone extracts. The difference can be seen using X-ray crystallography. This may explain why a 20-hydroxyecdysone extract with puritiy greater than 99% can be considerbly more effective than a slightly less pure extract.
There is controversy as to how much ecdysterone someone must consume to obtain desired results. The debate has risen due to the various extracts that have been used in the many different ecdysterone containing products. The quality of the ecdysterone extract greatly influences effectiveness. We have found that a 20 mg dose off a 99% 20hydroxyecdysone in crystalline form is effective and should be taken two to threes times a day. Ecdysterone has a relatively short half life, so frequent dosing is necessary. Many companies using a cheaper, lesser pure extracts suggest consumers to take much higher amounts to receive benefits. We are convinced that 20 mg of EcdyMorph is more beneficial than several hundred milligrams of a Cyanotis Vaga ecdysterone extract.
The Science and Clinical Studies
Phytoecdysteroids, which are structurally identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. They also have been reported to have effects in lowering of cholesterol, and management of healthy blood glucose levels.
There have not been numerous human studies done on ecdysterone . More importantly, very few studies have been conducted using a 99% 20-hydroxyecdysone extract. There is a particular study done with athletes published in the Journal of the International Society of Sports Nutrition. It was titled: “Effects of Methoxyisoflavone, Ecdysterone, and Sulfo-Polysaccharide Supplementation on Training Adaptations in Resistance-Trained Males”. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129166/ This was a very disappointing study. This study was most likely designed to discredit the effectiveness of ecdysterone as a nutritional supplement. They used a cheap ecdysterone extract and had the athletes take one single dose daily. The study was designed to fail and was most likely funded by a company that didn't have ecdysterone in their product line. At the time of the study there were a couple good ecdysterone products available that contained a 97% 20-hydroxyecdysone. These product were effective at dose ranging from 10-20 mg.
There have been two recent studies with a 99% 20-Hydroxyecdysone on mice suggesting its ability to increase muscle protein synthesis, reducing body fat, and produce an anti-diabetic effect. The studies are very interesting and can be found on the internet. The studies are listed below.
20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat. Phytomedicine: International Journal of Phytotherapy & Phytopharmacology; September 1, 2008, Volume: 15 Issue: 9 Page: 691(8)
20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 296:433-439, 2009.
The results of these studies were very impressive. We realize that consumers are not Rodentia, but the findings support anecdotal evidence collected throughout the years from consumers who used products containing Ecdymorph (99% 20-hydroxyecdysone).
The most interesting study with ecdysteroids done to date was published in 2008. Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells. J. Agric. Food Chem. 2008, 56, 3532–3537. This study not only measured an increase in protein synthesis, but also suggested how ecdysteroids work. The conclusion of the study: "In mammals, which seem to lack homologous receptors, the molecular mechanisms of ecdysteroid action are still unknown. Although our findings suggest that ecdysteroids may be mediated by a pathway that converges on the PI3K pathway, rather than on the androgen receptor pathway, more study is needed to confirm this hypothesis".
Other notable studies:
* Chermnykh, N.S., et.al. (1988). The action of methandrostenolone and ecdysterone on the physical of animals and on protein metabolism in the skeletal muscles. Farmakol. Tok. (USSR). 51, 57-60
* Simakin, S. Yu., et al., (1988). The Combined Use of Ecdisten and the Product 'Bodrost' during Training in Cyclical Types of Sport. Scientific Sports Bulletin, No. 2