I did have similar issues with some product, but not all of them have the same issue. Most products that are heavy in stimulants probably produce similar effects, but also a lot of addeditives are added to the formula to improve taste, texture and mixability of the ingredients. I think you need to explore and experiment with other products until you find what works for you best. Some products give me the bathroom runs and I get a stomach ache right away, while others purely give me a huge discomfort and pain. I usually stop taking them after 1-2 times because a good product should not make me feel that way (unless it was a free product or sample then I am OK, but why would I pay for something that gives me discomfort!!!). I decided to never use proprietary blend products for my pre-workouts or any product where their ingredient dosage in the supplement fact (grams) don't add up to the total dosage/serving size indicating fillers and crap added to the product which could be the cause of the issues. I stick with clean products that work, like UP-LIFT, Bulldozer XL5000, BodyOctane, CLOUT, CGT-10 ..etc. These products use no fillers, no crap and no proprietary blends.
It is not true that you should get used to this discomfort and live with it, people react differently. If your body is upset from ingesting something, then it is a sign for you to stop and not to keep forcing it.