This study shows that Cissus is capable of preventing seizures in rats viareceptor antagonism.
"The results lead to the conclusion that the extract of C. quadrangularis
possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine in Africa, in the treatment of insomnia and epilepsy."
"Effect of C. quadrangularis on NMDA-induced turning
The extract of C. quadrangularis dose dependently and
significantly antagonized NMDA- induced turning behavior
in mice. 50, 83.3 and 83.3% of mice were protected
at the doses of 100, 200 and 500 mg/kg respectively.
Animals were completely protected both by the extract
and by D-AP7 (dose 1000 mg/kg and D-AP7, p < 0.001),
NMDA recpetor antagonism explains cissus's analgesic effects. "the use of NMDA-receptor antagonists in the early postinjury phase, or even before, may blunt or even preempt central sensitization and the subsequent development of chronic pain."
I'd post sources but can't yet.
I don't take DAA but i figured others might wanna see this. People are adding (an NMDA agonist) to supplement regimens. Possible drug interaction??