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Cissus as an NMDA antagonist

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iambatman

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This study shows that Cissus is capable of preventing seizures in rats via nmda receptor antagonism.



"The results lead to the conclusion that the extract of C. quadrangularis
possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine in Africa, in the treatment of insomnia and epilepsy."

"Effect of C. quadrangularis on NMDA-induced turning
behavior
The extract of C. quadrangularis dose dependently and
significantly antagonized NMDA- induced turning behavior
in mice. 50, 83.3 and 83.3% of mice were protected
at the doses of 100, 200 and 500 mg/kg respectively.
Animals were completely protected both by the extract
and by D-AP7 (dose 1000 mg/kg and D-AP7, p < 0.001),
(Figure 2)."

NMDA recpetor antagonism explains cissus's analgesic effects. "the use of NMDA-receptor antagonists in the early postinjury phase, or even before, may blunt or even preempt central sensitization and the subsequent development of chronic pain."

I'd post sources but can't yet.
I don't take DAA but i figured others might wanna see this. People are adding D-aspartic acid (an NMDA agonist) to supplement regimens. Possible drug interaction??
 
damn. very interesting. might just look into getting some ALCAR.
 
That would be great except for the fact that if you are not prone to seizures this is doing more harm than good. NMDA antagonists, such as dextromethorphan will cause less memory retention as NDMA receptors are are integral in the hippocampus for forming memories. This is why those who "robo-trip" on alcohol and DM dumb themselves up fairly quickly!
 
Agmatine induced NMDA antagonism in individuals undergoing near death experiences.

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MAxximal said:
Agmatine induced NMDA antagonism in individuals undergoing near death experiences.

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Click to expand...


i've read that agmatine's affinity for the NDMA receptors is like 1/50,000th of designed NDMA antagonist drugs, but i can't remember where i saw that.. most likely due to my cissus and agmatine regimen.


There's also a study that shows ALCAR reduces excess glutamate in people with AIDS. This could be because an increase in receptors? i'll post when i find it.
 
iambatman said:
damn. very interesting. might just look into getting some ALCAR.
Click to expand...

When you do that, make sure to also check out Arginocarn, provided by Primordial Performance. Im a huge fan and advocate of L Carnitine, and its one of the main reasons why im repping for this company now. They have the 2 best versions of L carnitine out right now imo. GPLC for real N.O. induced pumps and Arginocarn wich is basically a super version of Alcar. Its nearly 20% more effective because of the added arginine addition.
 
rulk22 said:
When you do that, make sure to also check out Arginocarn, provided by Primordial Performance. Im a huge fan and advocate of L Carnitine, and its one of the main reasons why im repping for this company now. They have the 2 best versions of L carnitine out right now imo. GPLC for real N.O. induced pumps and Arginocarn wich is basically a super version of Alcar. Its nearly 20% more effective because of the added arginine addition.
Click to expand...


all are carnitines and all works different.

like L-Carnitine Fumarate and L-Carnitine Tartrate
 
MAxximal said:
Agmatine induced NMDA antagonism in individuals undergoing near death experiences.

Invalid Link Removed
Click to expand...
wouldn't it be interesting if they could determine for sure that Agmatine was the culprit in near death experiences as well as if those that experienced near death experiences (possibly from a higher endogenous agmatine release) had less residual brain injury from ischemia or some sort of trauma.
 
jgassen15 said:
wouldn't it be interesting if they could determine for sure that Agmatine was the culprit in near death experiences as well as if those that experienced near death experiences (possibly from a higher endogenous agmatine release) had less residual brain injury from ischemia or some sort of trauma.
Click to expand...

Hmmm need more research i planning start using this soon
 
MAxximal said:
all are carnitines and all works different.

like L-Carnitine Fumarate and L-Carnitine Tartrate
Click to expand...

Im a fan of all Carnitines, but some need insulin mimetics for better overall absorption. Acetyl L Carnitine doesn't need one, as it easily crosses over the cell membrane while the others do not. It's also faster in the speed of absorption because of this. It's worth mentioning for those looking for the most advanced form of L Carnitine.
 
Tartrate is naturally found in some foods, acts to stabilize l-carnitine. l-Carnitine is a dipeptide found in great abundance in the body, especially the heart and skeletal muscle. It maintains efficient fat utilization by transporting long-chain fatty acids into the mitochondria where they can be broken down by a process called beta oxidation (fat metabolism) to produce energy IMO is one the BEST type of Carnitines :D


The body can make small amounts of L-Carnitine.
To do so, the body needs need the amino acids lysine and methionine and vitamins such as niacin, B6, and vitamin C. a shortage of any of these nutrients, can lower carnitine levels and reduce fat burning . Lysine has been shown to boost carnitine levels. Lysine is the amino acid precursor that builds the carnitine molecule
 
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