Cissus as an NMDA antagonist

  1. iambatman
    Guest
    iambatman's Avatar

    Cissus as an NMDA antagonist


    This study shows that Cissus is capable of preventing seizures in rats via nmda receptor antagonism.



    "The results lead to the conclusion that the extract of C. quadrangularis
    possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine in Africa, in the treatment of insomnia and epilepsy."

    "Effect of C. quadrangularis on NMDA-induced turning
    behavior
    The extract of C. quadrangularis dose dependently and
    significantly antagonized NMDA- induced turning behavior
    in mice. 50, 83.3 and 83.3% of mice were protected
    at the doses of 100, 200 and 500 mg/kg respectively.
    Animals were completely protected both by the extract
    and by D-AP7 (dose 1000 mg/kg and D-AP7, p < 0.001),
    (Figure 2)."

    NMDA recpetor antagonism explains cissus's analgesic effects. "the use of NMDA-receptor antagonists in the early postinjury phase, or even before, may blunt or even preempt central sensitization and the subsequent development of chronic pain."

    I'd post sources but can't yet.
    I don't take DAA but i figured others might wanna see this. People are adding D-aspartic acid (an NMDA agonist) to supplement regimens. Possible drug interaction??

  2. Elite Member
    stxnas's Avatar
    Stats
    5'8"  195 lbs.
    Join Date
    Jan 2006
    Age
    33
    Posts
    9,983
    Rep Power
    969168
    Level
    68
    Lv. Percent
    59.53%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority

    Interesting post.
  3. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080
    Level
    55
    Lv. Percent
    25.08%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


    •   
       

  4. iambatman
    Guest
    iambatman's Avatar

    damn. very interesting. might just look into getting some ALCAR.
  5. Banned
    FitnFirm's Avatar
    Join Date
    Apr 2006
    Posts
    3,635
    Rep Power
    0
    Level
    41
    Lv. Percent
    99.72%
    Achievements Posting Pro

    Very interesting data
  6. Board Sponsor
    Athletix's Avatar
    Stats
    5'10"  0 lbs.
    Join Date
    Dec 2009
    Posts
    755
    Rep Power
    631574
    Level
    37
    Lv. Percent
    70.23%
    Achievements Reputation ProReputation Authority

    That would be great except for the fact that if you are not prone to seizures this is doing more harm than good. NMDA antagonists, such as dextromethorphan will cause less memory retention as NDMA receptors are are integral in the hippocampus for forming memories. This is why those who "robo-trip" on alcohol and DM dumb themselves up fairly quickly!
    www.athletixsports.com Facebook: Athletix Sports Instagram: @athletixsports Twitter: @Athletix_Sports.
  7. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080
    Level
    55
    Lv. Percent
    25.08%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority

    Agmatine induced NMDA antagonism in individuals undergoing near death experiences.

    http://www.neurotransmitter.net/neardeath.html
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  8. New Member
    jgassen15's Avatar
    Stats
    6'1"  212 lbs.
    Join Date
    Feb 2010
    Posts
    226
    Rep Power
    191
    Level
    12
    Lv. Percent
    75.72%

    Quote Originally Posted by MAxximal View Post
    Agmatine induced NMDA antagonism in individuals undergoing near death experiences.

    http://www.neurotransmitter.net/neardeath.html

    i've read that agmatine's affinity for the NDMA receptors is like 1/50,000th of designed NDMA antagonist drugs, but i can't remember where i saw that.. most likely due to my cissus and agmatine regimen.


    There's also a study that shows ALCAR reduces excess glutamate in people with AIDS. This could be because an increase in receptors? i'll post when i find it.
  9. Senior Member
    rulk22's Avatar
    Stats
    5'10"  267 lbs.
    Join Date
    Dec 2009
    Posts
    2,227
    Rep Power
    23082
    Level
    34
    Lv. Percent
    54.69%
    Achievements Reputation ProPosting Pro

    Quote Originally Posted by iambatman View Post
    damn. very interesting. might just look into getting some ALCAR.
    When you do that, make sure to also check out Arginocarn, provided by Primordial Performance. Im a huge fan and advocate of L Carnitine, and its one of the main reasons why im repping for this company now. They have the 2 best versions of L carnitine out right now imo. GPLC for real N.O. induced pumps and Arginocarn wich is basically a super version of Alcar. Its nearly 20% more effective because of the added arginine addition.
    Primordial Performance
    ( at heart )
  10. New Member
    jgassen15's Avatar
    Stats
    6'1"  212 lbs.
    Join Date
    Feb 2010
    Posts
    226
    Rep Power
    191
    Level
    12
    Lv. Percent
    75.72%
  11. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080
    Level
    55
    Lv. Percent
    25.08%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority

    Quote Originally Posted by rulk22 View Post
    When you do that, make sure to also check out Arginocarn, provided by Primordial Performance. Im a huge fan and advocate of L Carnitine, and its one of the main reasons why im repping for this company now. They have the 2 best versions of L carnitine out right now imo. GPLC for real N.O. induced pumps and Arginocarn wich is basically a super version of Alcar. Its nearly 20% more effective because of the added arginine addition.

    all are carnitines and all works different.

    like L-Carnitine Fumarate and L-Carnitine Tartrate
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  12. New Member
    jgassen15's Avatar
    Stats
    6'1"  212 lbs.
    Join Date
    Feb 2010
    Posts
    226
    Rep Power
    191
    Level
    12
    Lv. Percent
    75.72%

    Quote Originally Posted by MAxximal View Post
    Agmatine induced NMDA antagonism in individuals undergoing near death experiences.

    http://www.neurotransmitter.net/neardeath.html
    wouldn't it be interesting if they could determine for sure that Agmatine was the culprit in near death experiences as well as if those that experienced near death experiences (possibly from a higher endogenous agmatine release) had less residual brain injury from ischemia or some sort of trauma.
  13. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080
    Level
    55
    Lv. Percent
    25.08%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority

    Quote Originally Posted by jgassen15 View Post
    wouldn't it be interesting if they could determine for sure that Agmatine was the culprit in near death experiences as well as if those that experienced near death experiences (possibly from a higher endogenous agmatine release) had less residual brain injury from ischemia or some sort of trauma.
    Hmmm need more research i planning start using this soon
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  14. Senior Member
    rulk22's Avatar
    Stats
    5'10"  267 lbs.
    Join Date
    Dec 2009
    Posts
    2,227
    Rep Power
    23082
    Level
    34
    Lv. Percent
    54.69%
    Achievements Reputation ProPosting Pro

    Quote Originally Posted by MAxximal View Post
    all are carnitines and all works different.

    like L-Carnitine Fumarate and L-Carnitine Tartrate
    Im a fan of all Carnitines, but some need insulin mimetics for better overall absorption. Acetyl L Carnitine doesn't need one, as it easily crosses over the cell membrane while the others do not. It's also faster in the speed of absorption because of this. It's worth mentioning for those looking for the most advanced form of L Carnitine.
    Primordial Performance
    ( at heart )
  15. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080
    Level
    55
    Lv. Percent
    25.08%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority

    Tartrate is naturally found in some foods, acts to stabilize l-carnitine. l-Carnitine is a dipeptide found in great abundance in the body, especially the heart and skeletal muscle. It maintains efficient fat utilization by transporting long-chain fatty acids into the mitochondria where they can be broken down by a process called beta oxidation (fat metabolism) to produce energy IMO is one the BEST type of Carnitines


    The body can make small amounts of L-Carnitine.
    To do so, the body needs need the amino acids lysine and methionine and vitamins such as niacin, B6, and vitamin C. a shortage of any of these nutrients, can lower carnitine levels and reduce fat burning . Lysine has been shown to boost carnitine levels. Lysine is the amino acid precursor that builds the carnitine molecule
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  16. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080
    Level
    55
    Lv. Percent
    25.08%
    Achievements Reputation ProReputation AuthorityPosting ProPosting Authority

    and this last two form of them

    L-Carnitine Creatinate and L-Carnitine Taurinate
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  

  
 

Similar Forum Threads

  1. NMDA bulk?
    By bkprice in forum Nutraplanet
    Replies: 6
    Last Post: 07-08-2012, 04:10 PM
  2. Muscle Warfare Stack whit NMDA
    By siima in forum Supplement Logs
    Replies: 0
    Last Post: 05-14-2011, 12:45 PM
  3. propadrol ep ( natty test booster containing DAA and NMDA
    By ThER6KinG in forum E-Pharm Nutrition
    Replies: 8
    Last Post: 12-16-2010, 12:52 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in