Alright, for those who have ranor are currently in week 2 or further, can you guys please give me an honest and unbiased review. I have posted several questions regarding 3,3-T2 and can't seem to get conclusive answers.
I have used an endless amount of time trying to find clinical/scholarly/solid supporting data on 3,3-T2 and cannot find nothing claiming it to support lipolysis. Everything that I find on clearly states that the 3,5 isomer and not the 3,3 isomer of T2 has an effect on resting BMR, lipolysis, and anything pertaining to fat loss. I have posted this in the i-Force company forum thinking I'd get some kind of an answer, but to no avail.
Now on the other hand, practically all the reviews on has been positive. I have Alpha-T2 and really want to run it during this winter. I've ran and was very pleased with it, and actually still have some left. We all remember the whole i-Force thing with Gaspari claiming that they put an exceedingly amount of 3,5-T2 and under dosed 3,3; which we all then found out was completely false.
Again, I have looked hard to find any studies showing that 3,3 is biologically active in lipolysis and/or resting BMR or even any kind of uncoupling actions. But like I said, everyone is having great results and I want to give it a shot but I'm finding it so odd that it works when so many studies claim that it doesn't. Here are some of the studies I've managed to find that say that the 3,5 isomer is what you want and not 3,3.
3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro -- Ball et al. 19 (2): 137 -- Journal of Molecular Endocrinology
3,5-Diiodothyronine in vivo maintains euthyroidal expression of type 2 iodothyronine deiodinase, growth hormone, and thyroid hormone receptor ?1 in the killifish ? AJP - Regu Physiol
Short-Term Stimulation of Lipogenesis by 3,5-L-Diiodothyronine in Cultured Rat Hepatocytes -- Giudetti et al. 146 (9): 3959 -- Endocrinology
3,5-Diiodo-l-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement ? AJP - Endo
ScienceDirect - Life Sciences : Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats
Also I understand the possible suppression issues with 3,5 but there's also supporting data saying that at non-supra physiological doses, there is barely any suppression and if there to be any, the thyroid will naturally regenerate and up-regulate itself.
If anyone can school me wrong with some studies, please do. Like I said, I would really like get up on the PES stacks but just want to be assured that I'm not getting into something that isn't exactly factual.