kill Fat Cells
- 12-14-2010, 08:46 AM
kill Fat Cells
I read some studies about "killing fat cells" what did you think?
Resveratrol and Quercetin
Enhanced inhibition of adipogenesis and induction ... [Life Sci. 2008] - PubMed result
Quercetin and Caffeine
Potentiation of beta-adrenoceptor agonist-mediated... [Biochem Pharmacol. 1994] - PubMed result
CLA and l-Arginine
Dietary Supplementation of l-Arginine and Conjugated Linoleic Acid Reduces Retroperitoneal Fat Mass and Increases Lean Body Mass in Rats ? J. Nutr.
CLA has been shown to cause apoptosis in rats but in human??
studies have also shown that CLA blocks the ‘fat sensor’ PPAR-gamma.
Curcumin also inhibits the production of PPAR-gamma, the sensor that alerts fat cells to the presence of fat. If the sensor works less well, fat cells absorb less fat.
Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice ? J. Nutr.
Capsaicin inhibit fat cell growth?
Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications ? Am J Clin Nutr
Dihydrocapsiate is similar to capsaicin, which is known for its thermogenic properties
Effect of dihydrocapsiate on resting metabolic rate in humans ? Am J Clin Nutr
- 12-14-2010, 11:47 AM
Thanks for posting these, Maxximal.
I should have payed attention in school, then maybe I could understand the terminology in these studies.
12-14-2010, 12:00 PM
12-14-2010, 01:18 PM
Hmmmm very interesting. I knew the goal has always been to shrink fat cells, but now it seems people are looking to just kill them!
I think there is a phosphotidylcholine + Bile Salt product being researched right now for this by big pharma
12-14-2010, 02:48 PM
12-14-2010, 03:27 PM
12-14-2010, 03:35 PM
12-14-2010, 03:40 PM
Oh BTW I've always been confused how much CLA to consume. Is it 4-6g a day? Like 3 caps of 2g a day?
Lockout Supplements Rep
Discount Code = anabolic05
12-14-2010, 05:10 PM
Great info! I have run CLA in high doses (8-10g per day) for several months with no results. It's still one of those supps, like glutamine, that people think works great or doesn't work at all.
12-14-2010, 05:12 PM
12-14-2010, 05:58 PM
This is a great thread. What would everyone reccomend for supps that activate the "stop it" switch on fat cells year round?
12-14-2010, 06:04 PM
12-14-2010, 06:15 PM
12-14-2010, 06:15 PM
12-14-2010, 06:47 PM
12-16-2010, 02:42 AM
But it has been associated with improved carcass weight parameters in neonates from prenatal exposure, with greater lean mass and smaller fat cells in the sow's adult offspring! Also shown to reduce risk of mammary cancer in matured female offspring. So if you want a healthy repartitioning result and possible anti-carcinogenic benefit that could last a lifetime in your unborn kids, you might consider suggesting it to your pregnant wives, lol. The benefit was also noted to be passed down to the offspring's offspring (2'nd and 3'rd generation), so a pretty cool potential epigenetic effect!
12-16-2010, 10:46 AM
I don't think fat cell apoptosis is a very great idea in the grand scheme of things. Fat cells are important stores to the body. Some drugs given to AIDs patients actually cause this effect and lead to something known as lipodystrophy syndrome. This is where the fat build up (which has to go somewhere if there is a calorie surplus) occurs around the neck, giving the person a hump. Not very sexy.
12-16-2010, 10:48 AM
12-16-2010, 02:12 PM
Ive used it and did it for more 2 weeks in total with various dosing schemes and delivery and it was HELL. Trust me its not worth it.
12-16-2010, 02:16 PM
12-16-2010, 02:39 PM
I guess this is one of those situatons where we should be getting Dr. D or some other really smart person to come in and teach us a lesson in biology.
12-17-2010, 06:16 AM
12-17-2010, 09:57 AM
Yeah, I wouldn't dream of pinning it after all I've read.
So you're saying it's not worth pursuing the TD idea?
If I'm not mistaken, weren't you the guy that posted about making your own local carrier for PGF?
I've read a lot of mixed results from people using it transdermal, seems to depend a lot on the carrier used.
12-17-2010, 10:00 AM
12-17-2010, 11:07 AM
I am also interested in using it to bring up a couple of asymmetrical muscles. Read about a guy having good success on his bicep.
This stuff is getting hard to find though...
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