Best compound for increaseing insulin sensitivity in muscle but not fat.
- 12-02-2010, 10:54 PM
- 12-03-2010, 12:59 PM
is an Indian herb which has been clinically proven to lower HbA1c, fasting blood glucose, and postprandial glucose levels dramatically (*11). Gymnema also increases the speed in which glucose is transported from the bloodstream into muscle tissue. In India a year long study was conducted using Gymnema daily, the study showed a decrease in fasting blood glucose levels from 232 mg/dL to 152 mg/dl, the control group had no change. (*12)The Gymnema group also experienced a significant drop in HbA1c(*12). In addition Gymnema has been shown to actually regenerate and multiply the number of insulin secreting beta cells in the pancreas. Regeneration and multiplication of beta cells means that those who have poor insulin sensitivity can now improve their bodies natural output of insulin. (*13)
Lots of good info and studies cited on the other ingredients on the product page at nutraplanet too.
12-03-2010, 01:04 PM
12-03-2010, 01:06 PM
12-03-2010, 01:26 PM
i have been reading alot about Indian Kino lately, seems it is in KAL's Sugar Defense product. From what I have read this may blow other GDA's away.
12-03-2010, 01:49 PM
When I use Recompadrol with no carbs diet my cravings for junk food becomes uncontrollable damn it (Ice cream) and things very sugary but seems down my sugar too low and believe or not after eat this crap hours later i stay in ketosis (very bad breath)
12-03-2010, 02:42 PM
12-03-2010, 02:44 PM
Sline sane with 300mg ALA. You're really not going to find anything that only activates the GLUT-4 receptors, but this is about as good as it gets.
M.Ed. Ex Phys
12-03-2010, 04:00 PM
12-03-2010, 04:17 PM
12-03-2010, 05:10 PM
12-03-2010, 05:15 PM
Curr Opin Investig Drugs. 2009 Apr;10(4):353-8.
4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome.
Jetté L, Harvey L, Eugeni K, Levens N.
BELLUS Health Inc, 275 Boulevard Armand-Frappier, Laval, Quebec H7V 4A7, QC, Canada.
The plant fenugreek has been used for centuries as a treatment for diabetes. This article presents evidence that the major isomer of 4-hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, is responsible for the effects of this plant on glucose and lipid metabolism. 4-Hydroxyisoleucine was demonstrated to stimulate glucose-dependent insulin secretion by a direct effect on pancreatic islets. In addition to stimulating insulin secretion, 4-hydroxyisoleucine reduced insulin resistance in muscle and/or liver by activating insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. 4-Hydroxyisoleucine also reduced body weight in diet-induced obese mice. The decrease in body weight was associated with a marked decrease in both plasma insulin and glucose levels, both of which are elevated in this animal model. Finally, 4-hydroxyisoleucine decreased elevated plasma triglyceride and total cholesterol levels in a hamster model of diabetes. Based on the beneficial metabolic properties that have been demonstrated, 4-hydroxyisoleucine, a simple, plant-derived amino acid, may represent an attractive new candidate for the treatment of type 2 diabetes, obesity and dyslipidemia, all key components of metabolic syndrome
12-03-2010, 05:16 PM
12-03-2010, 05:17 PM
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12-03-2010, 05:20 PM
12-03-2010, 05:50 PM
When I'm doing refeeds (utilizing GDAs) after carb restriction, especially after my first carb up after a Friday fullbody workout, it feels like my skin is going to burst all over
12-03-2010, 06:13 PM
12-03-2010, 07:57 PM
12-03-2010, 08:02 PM
12-03-2010, 08:05 PM
12-03-2010, 08:07 PM
Ayyy looks like fat mass was measured...too lazy to read the FT atm, but here's the reference:
J Int Soc Sports Nutr. 2010 Oct 27;7:34.
The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males.
Poole C, Bushey B, Foster C, Campbell B, Willoughby D, Kreider R, Taylor L, Wilborn C.
Human Performance Lab, Department of Exercise and Sport Science, University of Mary Hardin-Baylor, Belton, Texas, 76513, USA. [email protected].
BACKGROUND: Fenugreek (Trigonella foenum-graecum) is a leguminous, annual plant originating in India and North Africa. In recent years Fenugreek has been touted as an ergogenic aid. The purpose of this study was to evaluate the effects of Fenugreek supplementation on strength and body composition.
METHODS: 49 Resistance trained men were matched according to body weight and randomly assigned to ingest in a double blind manner capsules containing 500 mg of a placebo (N = 23, 20 ± 1.9 years, 178 ± 6.3 cm, 85 ± 12.7 kg, 17 ± 5.6 %BF) or Fenugreek (N = 26, 21 ± 2.8 years, 178 ± 6 cm, 90 ± 18.2 kg, 19.3 ± 8.4 %BF). Subjects participated in a supervised 4-day per week periodized resistance-training program split into two upper and two lower extremity workouts per week for a total of 8-weeks. At 0, 4, and 8-weeks, subjects underwent hydrodensiometery body composition, 1-RM strength, muscle endurance, and anaerobic capacity testing. Data were analyzed using repeated measures ANOVA and are presented as mean ± SD changes from baseline after 60-days.
RESULTS: No significant differences (p > 0.05) between groups were noted for training volume. Significant group × time interaction effects were observed among groups in changes in body fat (FEN: -2.3 ± 1.4%BF; PL: -0.39 ± 1.6 %BF, p < 0.001), leg press 1-RM (FEN: 84.6 ± 36.2 kg; PL: 48 ± 29.5 kg, p < 0.001), and bench press 1-RM (FEN: 9.1 ± 6.9 kg; PL: 4.3 ± 5.6 kg, p = 0.01). No significant interactions was observed among groups for Wingate power analysis (p = 0.95) or muscular endurance on bench press (p = 0.87) or leg press (p = 0.61). In addition, there were no changes among groups in any clinical safety data including lipid panel, liver function, kidney function, and/or CBC panel (p > 0.05).
CONCLUSION: It is concluded that 500 mg of this proprietary Fenugreek extraction had a significant impact on both upper- and lower-body strength and body composition in comparison to placebo in a double blind controlled trial. These changes were obtained with no clinical side effects.
PMID: 20979623 [PubMed - in process]PMCID: PMC2978122Free PMC Article
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12-04-2010, 11:24 AM
12-04-2010, 12:58 PM
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12-04-2010, 03:04 PM
4- hydroxyisoleucine is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown that adding fenugreek to your diet reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity.
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4-hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time.
1. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion
Diabetes, Vol 47, Issue 2 206-210,1998
2. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.
Am J Physiol. 1999 Oct;277(4 Pt 1):E617-23.
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