Anyone use straight creatine anymore?
- 08-29-2010, 03:40 PM
link to source: http://www.fasebj.org/cgi/content/me.../954.13?ck=nck
Pharmacological vasodilation improves the anabolic response of muscle protein synthesis to insulin in elders -- Lee et al. 23 (1): 954.13 -- The FASEB Journal
Loss of muscle with aging (sarcopenia) contributes to disability in elders. Aging is associated with an insulin resistance of muscle protein anabolism, which correlates with impaired insulin-induced muscle vasodilation and nutrient delivery.
We hypothesized that pharmacological restoration of muscle perfusion to youthful values during hyperinsulinemia would improve the response of muscle protein synthesis and anabolism in older subjects.
We measured blood flow (BF), anabolic signaling, and muscle protein synthesis (Rd) and breakdown (Ra) with stable isotope tracers at baseline and during insulin in one leg in 12 healthy, non-diabetic older subjects (71 ± 2 yrs) divided in two groups: CTRL (insulin only) and SNP (insulin + sodium nitroprusside to double blood flow above baseline).
Blood flow and phenylalanine delivery increased significantly (P<0.05) in SNP only. Muscle protein synthesis (nmol·min-1 ·100mL leg-1) increased in SNP (35 ± 4 to 102 ± 26), but not in CTRL (34 ± 10 to 45 ± 10), while breakdown did not change in either group. Akt/PKB phosphorylation increased in both groups but to a larger extent in SNP (P<0.05) and S6K1 phosphorylation tended to increase more in SNP (P = 0.068).
In conclusion, pharmacological restoration of muscle perfusion and nutrient delivery during hyperinsulinemia increased muscle protein synthesis in elders.나는 2000년 10월 매들린 올브라이트 전 미 국무장관 매들린 사랑, 그 중 한 뜨거운 젠장!
- 08-29-2010, 03:48 PM
08-29-2010, 03:51 PM
but i in my experience believe nitrates are effective.
dont know much about methoxy, and when it comes to Ecdy, Ebol is the best product ive ever used for a total non-hormonal product outside of creatine, but there are other things in it as well.
나는 2000년 10월 매들린 올브라이트 전 미 국무장관 매들린 사랑, 그 중 한 뜨거운 젠장!
08-29-2010, 03:52 PM
08-29-2010, 03:55 PM
08-29-2010, 03:56 PM
08-29-2010, 05:22 PM
CEE screwed up my digestion. I would say put natural creatine in your body, because everything else may or may not have weird chemical side effects.
08-29-2010, 06:42 PM
08-29-2010, 06:46 PM
08-29-2010, 07:01 PM
08-29-2010, 07:21 PM
I like CreaPure, Ancient Strength, Trinitine, C-bol was solid too, green mag has betaine which I do like.
doing my own thang!
08-30-2010, 02:23 PM
10-24-2010, 04:29 PM
Didnt want to start a new post about an old topic, so dug this up. Does anyone using monohydrate do more than 5gs per day. Currently I take roughly 6-7 grams post workout every day. Been thinking of doing 5g with jack3d 30 mins pre w/o, and then 5g again post w/o. Sound ok?
10-24-2010, 05:00 PM
10-24-2010, 05:06 PM
I usually take 5g upon waking prior to breakfast so I flood my system with the goody juice which will be efficiently welcomed with open insulinogenic arms with breakfast's assortment of high GI carbohydrates and Leucine-rich Whey protein. I then create an anabolic safety net by creating a buffer zone before, during, and after training by consuming 3/5/5g in respective order, consuming the final post workout dose with Need 2 Slin to enhance the anabolic window's duration and nutrient uptake.
Happy Creatining to you!
10-24-2010, 06:17 PM
10-25-2010, 01:41 AM
10-25-2010, 02:10 AM
10-25-2010, 03:22 AM
When my current 'special' creatine mix is finished I'll be switching back to good old monohydrate.. Because my current mix tastes like ASS!!
10-25-2010, 05:34 PM
That aggregate 15-18 grams per day drops drastically to 3-5g per day maximum on off days. Since I have never experienced severe stomach discomfort, and we are all aware of the multitude of benefits offered by this amazing supplement, paired with the fact I have more on hand than I can ever imagine using - this is my protocol.
10-25-2010, 06:52 PM
I like creatine mono because it is the closest thing to natural creatine. If anything dose make it more absorbable, which I am doubting, it would be less of a supplement, and moe of a performance enhancing chemical.
10-25-2010, 08:01 PM
MAP+CREPURE+BCAA= My post drink.... I do take Crepure when I wake up in am 3g
and my post I take 5g...
Diet is always the key to unlocking the door of success
10-25-2010, 08:51 PM
My nutrient repartitioner is also a creatine product, so yes, some days when I was using it, I was having a lot more than ~5g of creatine daily - albeit not for the creatine.
However, be aware that once your body has reached its muscle creatine threshold, then using more than 3-5g of creatine daily is not going to saturate them any further, so there's no point in using more than that daily.
The Primordial Woman
10-26-2010, 12:12 AM
10-26-2010, 01:26 AM
10-26-2010, 10:54 AM
10-26-2010, 11:04 AM
I think she means everybody has a maximum. More muscle does mean more creatine holding capacity though.. right?
10-26-2010, 11:25 AM
A larger individual will have an overall larger amount of creatine in their system than a smaller individual because they have more dense weight, but it will still take the same amount of time to build up that creatine muscle threshold (i.e. ~20g a day for ~5 days (saturation occurs after 2-3 days), or ~5g a day for ~21 days) (Burke, et al., 2006; Harris, Soderlund & Hultman, 1992).
Your total muscle creatine concentration can only be increased by ~20%, with ~20% of that increase in muscle creatine being stored as Creatine Phosphate (Harris, Soderlund & Hultman, 1992).
Therefore, you can see that even 5g of creatine a day is plenty adequate for the biggest of individuals.
See my comments above.
The Primordial Woman
10-26-2010, 12:04 PM
I take maybe 4-5g a day, and no creapure on workout days due to using ASGT pre-wo. Really helps me stretch out my pre-wo supps.
11-02-2010, 04:06 PM
What if you don't take creatine on your days off, i.e. I workout about 5 days a week, but Fri and Sat I do not, and I do not take any creatine on those days. Do I lose saturation and need to load again on Sun/Mon?
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